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    [{"orgOrder":0,"company":"Alcon Inc","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Ophthalmology","country":"U.S.A","productType":"Other Small Molecule","year":"2022","type":"Inapplicable","leadProduct":"Netarsudil","moa":"ROCK","graph1":"Ophthalmology","graph2":"Phase III","graph3":"Alcon Inc","amount2":0,"highestDevelopmentShortName":"Ph III","therapeuticAreaShortName":"Ophthalmology","amount2New":0,"dosageForm":"Ophthalmic Solution","sponsorNew":"Alcon Inc \/ Inapplicable","highestDevelopmentStatusID":"10","companyTruncated":"Alcon Inc \/ Inapplicable"},{"orgOrder":0,"company":"Alcon Inc","sponsor":"Santen Pharmaceutical","pharmaFlowCategory":"D","therapeuticArea":"Ophthalmology","country":"U.S.A","productType":"Other Small Molecule","year":"2021","type":"Expanded Collaboration","leadProduct":"Netarsudil","moa":"ROCK","graph1":"Ophthalmology","graph2":"Approved FDF","graph3":"Alcon Inc","amount2":0.17000000000000001,"highestDevelopmentShortName":"Approved 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Inc","pharmaFlowCategory":"D","therapeuticArea":"Ophthalmology","country":"U.S.A","productType":"Other Small Molecule","year":"2022","type":"Acquisition","leadProduct":"Netarsudil","moa":"||ROCK","graph1":"Ophthalmology","graph2":"Approved FDF","graph3":"Aerie Pharmaceuticals","amount2":0.93000000000000005,"highestDevelopmentShortName":"Approved FDF","therapeuticAreaShortName":"Ophthalmology","amount2New":0.93000000000000005,"dosageForm":"Ophthalmic Solution","sponsorNew":"Aerie Pharmaceuticals \/ Alcon Inc","highestDevelopmentStatusID":"15","companyTruncated":"Aerie Pharmaceuticals \/ Alcon Inc"},{"orgOrder":0,"company":"Aerie Pharmaceuticals","sponsor":"Alcon Inc","pharmaFlowCategory":"D","therapeuticArea":"Ophthalmology","country":"U.S.A","productType":"Other Small Molecule","year":"2022","type":"Acquisition","leadProduct":"Netarsudil","moa":"||ROCK","graph1":"Ophthalmology","graph2":"Approved FDF","graph3":"Aerie Pharmaceuticals","amount2":0.93000000000000005,"highestDevelopmentShortName":"Approved FDF","therapeuticAreaShortName":"Ophthalmology","amount2New":0.93000000000000005,"dosageForm":"Ophthalmic Solution","sponsorNew":"Aerie Pharmaceuticals \/ Alcon Inc","highestDevelopmentStatusID":"15","companyTruncated":"Aerie Pharmaceuticals \/ Alcon Inc"},{"orgOrder":0,"company":"Aerie Pharmaceuticals","sponsor":"Alcon Inc","pharmaFlowCategory":"D","therapeuticArea":"Ophthalmology","country":"U.S.A","productType":"Other Small Molecule","year":"2022","type":"Acquisition","leadProduct":"Netarsudil","moa":"||ROCK","graph1":"Ophthalmology","graph2":"Approved FDF","graph3":"Aerie Pharmaceuticals","amount2":0,"highestDevelopmentShortName":"Approved FDF","therapeuticAreaShortName":"Ophthalmology","amount2New":0.93000000000000005,"dosageForm":"Ophthalmic Solution","sponsorNew":"Aerie Pharmaceuticals \/ Alcon Inc","highestDevelopmentStatusID":"15","companyTruncated":"Aerie Pharmaceuticals \/ Alcon Inc"},{"orgOrder":0,"company":"Skye Bioscience","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Ophthalmology","country":"U.S.A","productType":"Controlled Substance","year":"2021","type":"Inapplicable","leadProduct":"Netarsudil","moa":"||CB1\/CB2 receptor","graph1":"Ophthalmology","graph2":"Phase I","graph3":"Skye Bioscience","amount2":0,"highestDevelopmentShortName":"Ph I","therapeuticAreaShortName":"Ophthalmology","amount2New":0,"dosageForm":"Ophthalmic Emulsion","sponsorNew":"Skye Bioscience \/ Inapplicable","highestDevelopmentStatusID":"6","companyTruncated":"Skye Bioscience \/ Inapplicable"},{"orgOrder":0,"company":"Skye Bioscience","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Ophthalmology","country":"U.S.A","productType":"Controlled Substance","year":"2021","type":"Inapplicable","leadProduct":"Netarsudil","moa":"||CB1\/CB2 receptor","graph1":"Ophthalmology","graph2":"Phase I","graph3":"Skye Bioscience","amount2":0,"highestDevelopmentShortName":"Ph I","therapeuticAreaShortName":"Ophthalmology","amount2New":0,"dosageForm":"Ophthalmic Emulsion","sponsorNew":"Skye Bioscience \/ Inapplicable","highestDevelopmentStatusID":"6","companyTruncated":"Skye Bioscience \/ Inapplicable"},{"orgOrder":0,"company":"Skye Bioscience","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Ophthalmology","country":"U.S.A","productType":"Controlled Substance","year":"2021","type":"Inapplicable","leadProduct":"Netarsudil","moa":"||CB1\/CB2 receptor","graph1":"Ophthalmology","graph2":"Phase I","graph3":"Skye Bioscience","amount2":0,"highestDevelopmentShortName":"Ph I","therapeuticAreaShortName":"Ophthalmology","amount2New":0,"dosageForm":"Ophthalmic Emulsion","sponsorNew":"Skye Bioscience \/ Inapplicable","highestDevelopmentStatusID":"6","companyTruncated":"Skye Bioscience \/ Inapplicable"}]

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                            01

                            Aerie Pharmaceuticals

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                            Aerie Pharmaceuticals

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                            Lead Product(s) : Netarsudil,Latanoprost

                            Therapeutic Area : Ophthalmology

                            Study Phase : Approved FDF

                            Sponsor : Alcon Inc

                            Deal Size : $930.0 million

                            Deal Type : Acquisition

                            DEALS_DEV arrow-down

                            Alcon Completes Acquisition of Aerie Pharmaceuticals, Inc., Strengthening Company’s Ophthalmic Pharmaceutica...

                            Details : Alcon will add Rocklatan (netarsudil and latanoprost ophthalmic solution) and Rhopressa (netarsudil ophthalmic solution), as well as AR-15512, a Phase 3 candidate for dry eye disease, and a pipeline of several clinical and preclinical ophthalmic pharmace...

                            Product Name : Rocklatan

                            Product Type : Other Small Molecule

                            Upfront Cash : Undisclosed

                            December 22, 2022

                            Lead Product(s) : Netarsudil,Latanoprost

                            Therapeutic Area : Ophthalmology

                            Highest Development Status : Approved FDF

                            Sponsor : Alcon Inc

                            Deal Size : $930.0 million

                            Deal Type : Acquisition

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                            02

                            Aerie Pharmaceuticals

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                            Aerie Pharmaceuticals

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                            Lead Product(s) : Netarsudil,Latanoprost

                            Therapeutic Area : Ophthalmology

                            Study Phase : Approved FDF

                            Sponsor : Alcon Inc

                            Deal Size : Undisclosed

                            Deal Type : Acquisition

                            DEALS_DEV arrow-down

                            Alcon Completes Acquisition of Aerie Pharmaceuticals, Inc., Strengthening Company’s Ophthalmic Pharmaceutica...

                            Details : Through the transaction, Alcon has added the commercial products Rocklatan (netarsudil and latanoprost ophthalmic solution) 0.02%/0.005% and Rhopressa (netarsudil ophthalmic solution) 0.02%, as well as AR-15512, a Phase 3 product candidate for dry eye di...

                            Product Name : Rocklatan

                            Product Type : Other Small Molecule

                            Upfront Cash : Undisclosed

                            November 22, 2022

                            Lead Product(s) : Netarsudil,Latanoprost

                            Therapeutic Area : Ophthalmology

                            Highest Development Status : Approved FDF

                            Sponsor : Alcon Inc

                            Deal Size : Undisclosed

                            Deal Type : Acquisition

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                            03

                            Aerie Pharmaceuticals

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                            Lead Product(s) : Netarsudil,Latanoprost

                            Therapeutic Area : Ophthalmology

                            Study Phase : Approved FDF

                            Sponsor : Alcon Inc

                            Deal Size : $930.0 million

                            Deal Type : Acquisition

                            DEALS_DEV arrow-down

                            Alcon to Acquire Aerie Pharmaceuticals, Inc., Enhancing its Ophthalmic Pharmaceutical Portfolio

                            Details : Alcon will add Rocklatan (netarsudil and latanoprost ophthalmic solution) and Rhopressa (netarsudil ophthalmic solution), as well as AR-15512, a Phase 3 candidate for dry eye disease, and a pipeline of several clinical and preclinical ophthalmic pharmace...

                            Product Name : Rocklatan

                            Product Type : Other Small Molecule

                            Upfront Cash : Undisclosed

                            August 22, 2022

                            Lead Product(s) : Netarsudil,Latanoprost

                            Therapeutic Area : Ophthalmology

                            Highest Development Status : Approved FDF

                            Sponsor : Alcon Inc

                            Deal Size : $930.0 million

                            Deal Type : Acquisition

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                            04

                            Alcon Inc

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                            Alcon Inc

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                            Lead Product(s) : Netarsudil

                            Therapeutic Area : Ophthalmology

                            Study Phase : Phase III

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Aerie Pharmaceuticals Announces Presentations at the American Society of Cataract and Refractive Surgery (ASCR...

                            Details : Rocklatan (netarsudil and latanoprost), indicated for reduction of elevated IOP in patients with glaucoma or ocular hypertension, demonstrated consistent IOP reduction of ~9.5 mmHg and an average IOP reduction of 37% from baseline in European Phase 3B cl...

                            Product Name : Rhopressa

                            Product Type : Other Small Molecule

                            Upfront Cash : Inapplicable

                            April 20, 2022

                            Lead Product(s) : Netarsudil

                            Therapeutic Area : Ophthalmology

                            Highest Development Status : Phase III

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            05

                            Skye Bioscience

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                            Skye Bioscience

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                            Lead Product(s) : Tetrahydrocannabinol Valine Hemisuccinate,Netarsudil

                            Therapeutic Area : Ophthalmology

                            Study Phase : Preclinical

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Skye Bioscience Sponsored Research Presented at American Association of Pharmaceutical Scientists Meeting Phar...

                            Details : THC-VHS-NEC (SBI-100) + Rhopressa® (netarsudil) a Rho-Kinase Inhibitor combination , Produces Superior IOP Lowering Activity.THCVHS a synthetic molecule, developed to treat glaucoma.

                            Product Name : SBI-100

                            Product Type : Controlled Substance

                            Upfront Cash : Inapplicable

                            October 21, 2021

                            Lead Product(s) : Tetrahydrocannabinol Valine Hemisuccinate,Netarsudil

                            Therapeutic Area : Ophthalmology

                            Highest Development Status : Preclinical

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            06

                            Skye Bioscience

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                            Skye Bioscience

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                            Lead Product(s) : Tetrahydrocannabinol Valine Hemisuccinate,Netarsudil

                            Therapeutic Area : Ophthalmology

                            Study Phase : IND Enabling

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Skye Bioscience Completes THCVHS IND-enabling In Vitro Genotoxicity Studies

                            Details : THCVHS enables enhanced local delivery of the drug into the eye, provides significant lowering of intraocular pressure, minimal systemic exposure, and potential for neuroprotection.

                            Product Name : SBI-100

                            Product Type : Controlled Substance

                            Upfront Cash : Inapplicable

                            October 08, 2021

                            Lead Product(s) : Tetrahydrocannabinol Valine Hemisuccinate,Netarsudil

                            Therapeutic Area : Ophthalmology

                            Highest Development Status : IND Enabling

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            07

                            Alcon Inc

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                            Alcon Inc

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                            Lead Product(s) : Netarsudil

                            Therapeutic Area : Ophthalmology

                            Study Phase : Approved FDF

                            Sponsor : Santen Pharmaceutical

                            Deal Size : $168.0 million

                            Deal Type : Expanded Collaboration

                            DEALS_DEV arrow-down

                            Aerie Concludes Exclusive License Agreement With Santen for Rhopressa® and Rocklatan® in Europe and Several ...

                            Details : Santen will be responsible for all development and commercialization costs and activities related to the products in the territories covered by the agreement with the exception of a post-marketing clinical study to be conducted by Aerie in Europe for Rho...

                            Product Name : Rhopressa

                            Product Type : Other Small Molecule

                            Upfront Cash : $88.0 million

                            July 12, 2021

                            Lead Product(s) : Netarsudil

                            Therapeutic Area : Ophthalmology

                            Highest Development Status : Approved FDF

                            Sponsor : Santen Pharmaceutical

                            Deal Size : $168.0 million

                            Deal Type : Expanded Collaboration

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                            08

                            Skye Bioscience

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                            Skye Bioscience

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                            Lead Product(s) : Tetrahydrocannabinol Valine Hemisuccinate,Netarsudil

                            Therapeutic Area : Ophthalmology

                            Study Phase : Preclinical

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Skye Bioscience’s THCVHS Demonstrates Superior Therapeutic Benefit Compared to Glaucoma Standard of Care

                            Details : Data from this study also highlighted THCVHS’ superior IOP-lowering capability and duration of activity as a single agent compared to the current standard of care for the treatment of glaucoma, latanoprost.

                            Product Name : SBI-100

                            Product Type : Controlled Substance

                            Upfront Cash : Inapplicable

                            May 17, 2021

                            Lead Product(s) : Tetrahydrocannabinol Valine Hemisuccinate,Netarsudil

                            Therapeutic Area : Ophthalmology

                            Highest Development Status : Preclinical

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            09

                            Alcon Inc

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                            Alcon Inc

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                            Lead Product(s) : Netarsudil

                            Therapeutic Area : Ophthalmology

                            Study Phase : Approved FDF

                            Sponsor : Santen Pharmaceutical

                            Deal Size : $149.0 million

                            Deal Type : Licensing Agreement

                            DEALS_DEV arrow-down

                            Santen and Aerie Conclude Exclusive License Agreement for Rhopressa® and Rocklatan® in Japan and Several Oth...

                            Details : Santen will look after sales, marketing and pricing decisions relating to Rhopressa® and Rocklatan®. Aerie and Santen will collaborate for the first Phase 3 study for Rhopressa® in Japan.

                            Product Name : Rhopressa

                            Product Type : Other Small Molecule

                            Upfront Cash : $50.0 million

                            October 28, 2020

                            Lead Product(s) : Netarsudil

                            Therapeutic Area : Ophthalmology

                            Highest Development Status : Approved FDF

                            Sponsor : Santen Pharmaceutical

                            Deal Size : $149.0 million

                            Deal Type : Licensing Agreement

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