[{"orgOrder":0,"company":"Monopar Therapeutics","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Gastroenterology","country":"U.S.A","productType":"Other Small Molecule","year":"2022","type":"Inapplicable","leadProduct":"Clonidine","moa":"Adrenergic receptor alpha-2","graph1":"Gastroenterology","graph2":"Phase III","graph3":"Monopar Therapeutics","amount2":0,"highestDevelopmentShortName":"Ph III","therapeuticAreaShortName":"Gastroenterology","amount2New":0,"dosageForm":"Buccal Tablet","sponsorNew":"Monopar Therapeutics \/ Inapplicable","highestDevelopmentStatusID":"10","companyTruncated":"Monopar Therapeutics \/ Inapplicable"},{"orgOrder":0,"company":"Monopar Therapeutics","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Gastroenterology","country":"U.S.A","productType":"Other Small Molecule","year":"2023","type":"Inapplicable","leadProduct":"Clonidine","moa":"Adrenergic receptor alpha-2","graph1":"Gastroenterology","graph2":"Phase 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Inapplicable"},{"orgOrder":0,"company":"Monopar Therapeutics","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Gastroenterology","country":"U.S.A","productType":"Other Small Molecule","year":"2020","type":"Inapplicable","leadProduct":"Clonidine","moa":"Adrenergic receptor alpha-2","graph1":"Gastroenterology","graph2":"Phase III","graph3":"Monopar Therapeutics","amount2":0,"highestDevelopmentShortName":"Ph III","therapeuticAreaShortName":"Gastroenterology","amount2New":0,"dosageForm":"Buccal Tablet","sponsorNew":"Monopar Therapeutics \/ Inapplicable","highestDevelopmentStatusID":"10","companyTruncated":"Monopar Therapeutics \/ Inapplicable"},{"orgOrder":0,"company":"Monopar Therapeutics","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Gastroenterology","country":"U.S.A","productType":"Other Small Molecule","year":"2021","type":"Inapplicable","leadProduct":"Clonidine","moa":"Adrenergic receptor 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I","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Intravenous Infusion","sponsorNew":"Monopar Therapeutics \/ Inapplicable","highestDevelopmentStatusID":"6","companyTruncated":"Monopar Therapeutics \/ Inapplicable"},{"orgOrder":0,"company":"Monopar Therapeutics","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"U.S.A","productType":"Other Large Molecule","year":"2024","type":"Inapplicable","leadProduct":"MNPR-101-Lu","moa":"uPAR","graph1":"Oncology","graph2":"Phase I","graph3":"Monopar Therapeutics","amount2":0,"highestDevelopmentShortName":"Ph I","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Intravenous Infusion","sponsorNew":"Monopar Therapeutics \/ Inapplicable","highestDevelopmentStatusID":"6","companyTruncated":"Monopar Therapeutics \/ Inapplicable"},{"orgOrder":0,"company":"Monopar Therapeutics","sponsor":"Excel Diagnostics and Nuclear Oncology 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\/ Monopar Therapeutics"},{"orgOrder":0,"company":"Monopar Therapeutics","sponsor":"Cancer Science Institute of Singapore","pharmaFlowCategory":"D","therapeuticArea":"Oncology","country":"U.S.A","productType":"Antibody","year":"2023","type":"Collaboration","leadProduct":"225-Ac","moa":"||uPAR","graph1":"Oncology","graph2":"Preclinical","graph3":"Monopar Therapeutics","amount2":0,"highestDevelopmentShortName":"Preclinical","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"Monopar Therapeutics \/ Cancer Science Institute of Singapore","highestDevelopmentStatusID":"4","companyTruncated":"Monopar Therapeutics \/ Cancer Science Institute of Singapore"},{"orgOrder":0,"company":"Monopar Therapeutics","sponsor":"NorthStar Medical 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Diseases","graph2":"Undisclosed","graph3":"Monopar Therapeutics","amount2":0,"highestDevelopmentShortName":"Undisclosed","therapeuticAreaShortName":"Infectious Diseases","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"Monopar Therapeutics \/ NorthStar Medical Radioisotopes","highestDevelopmentStatusID":"1","companyTruncated":"Monopar Therapeutics \/ NorthStar Medical Radioisotopes"}]

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                          Top Deals by Deal Size (USD bn)

                          01

                          ChemOutsourcing
                          Not Confirmed
                          ChemOutsourcing
                          Not Confirmed

                          Lead Product(s) : MNPR-101-Lu

                          Therapeutic Area : Oncology

                          Study Phase : Phase I

                          Sponsor : Excel Diagnostics and Nuclear Oncology Center

                          Deal Size : Undisclosed

                          Deal Type : Collaboration

                          Details : MNPR-101 is Monopar’s proprietary antibody targeting the uPAR, which is expressed in numerous tumor types, including pancreatic, breast, colorectal, ovarian, and bladder.

                          Product Name : Undisclosed

                          Product Type : Other Large Molecule

                          Upfront Cash : Undisclosed

                          June 11, 2025

                          Lead Product(s) : MNPR-101-Lu

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I

                          Sponsor : Excel Diagnostics and Nuclear Oncology Center

                          Deal Size : Undisclosed

                          Deal Type : Collaboration

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                          02

                          ChemOutsourcing
                          Not Confirmed
                          ChemOutsourcing
                          Not Confirmed

                          Details : Monopar intends to use the net proceeds from the offering for clinical development of late-stage ALXN-1840 (tiomolibdate choline), which is being evaluated for the treatment of Wilson disease.

                          Product Name : Undisclosed

                          Product Type : Other Small Molecule

                          Upfront Cash : Undisclosed

                          December 20, 2024

                          Lead Product(s) : Tiomolibdate Choline

                          Therapeutic Area : Genetic Disease

                          Highest Development Status : Phase III

                          Sponsor : RA Capital Management

                          Deal Size : $40.0 million

                          Deal Type : Public Offering

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                          03

                          ChemOutsourcing
                          Not Confirmed
                          ChemOutsourcing
                          Not Confirmed

                          Details : MNPR-101-Zr is a radioactive uPAR modulating candidate, which is currently being evaluated for the treatment of uPAR-expressing triple-negative breast cancer and other tumors.

                          Product Name : Undisclosed

                          Product Type : Antibody

                          Upfront Cash : Inapplicable

                          December 09, 2024

                          Lead Product(s) : MNPR-101-Zr

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          04

                          ChemOutsourcing
                          Not Confirmed
                          ChemOutsourcing
                          Not Confirmed

                          Details : MNPR-101-PCTA-177Lu is a uPAR modulator antibody radiopharmaceutical drug candidate, which is currently being evaluated for the treatment of patients with solid tumors.

                          Product Name : Undisclosed

                          Product Type : Other Large Molecule

                          Upfront Cash : Inapplicable

                          December 05, 2024

                          Lead Product(s) : MNPR-101-Lu

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          05

                          ChemOutsourcing
                          Not Confirmed
                          ChemOutsourcing
                          Not Confirmed

                          Details : NorthStar will provide Monopar with the powerful therapeutic radioisotope actinium-225 (Ac-225) in its lead MNPR-101, radio-immuno-therapeutic (RIT) for the treatment of advanced cancers.

                          Product Name : Undisclosed

                          Product Type : Antibody

                          Upfront Cash : Undisclosed

                          November 06, 2024

                          Lead Product(s) : MNPR-101

                          Therapeutic Area : Oncology

                          Highest Development Status : Preclinical

                          Sponsor : NorthStar Medical Radioisotopes

                          Deal Size : Undisclosed

                          Deal Type : Collaboration

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                          06

                          ChemOutsourcing
                          Not Confirmed
                          ChemOutsourcing
                          Not Confirmed

                          Details : The net proceeds will be used to fund the clinical development of company's lead product MNPR-101-Zr, which is being evaluated for the treatment of uPAR-expressing triple-negative breast cancer.

                          Product Name : Undisclosed

                          Product Type : Antibody

                          Upfront Cash : Undisclosed

                          October 30, 2024

                          Lead Product(s) : MNPR-101-Zr

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I

                          Sponsor : Rodman & Renshaw LLC

                          Deal Size : $19.2 million

                          Deal Type : Public Offering

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                          07

                          ChemOutsourcing
                          Not Confirmed
                          ChemOutsourcing
                          Not Confirmed

                          Details : The net proceeds will be used to fund the clinical development of company's lead product MNPR-101-Zr, which is being evaluated for the treatment of uPAR-expressing triple-negative breast cancer.

                          Product Name : Undisclosed

                          Product Type : Antibody

                          Upfront Cash : Undisclosed

                          October 28, 2024

                          Lead Product(s) : MNPR-101-Zr

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I

                          Sponsor : Rodman & Renshaw LLC

                          Deal Size : Undisclosed

                          Deal Type : Public Offering

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                          08

                          ChemOutsourcing
                          Not Confirmed
                          ChemOutsourcing
                          Not Confirmed

                          Details : The net proceeds will be used to fund the clinical development of company's lead product MNPR-101-Zr, which is being evaluated for the treatment of uPAR-expressing triple-negative breast cancer.

                          Product Name : Undisclosed

                          Product Type : Antibody

                          Upfront Cash : Undisclosed

                          October 28, 2024

                          Lead Product(s) : MNPR-101-Zr

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I

                          Sponsor : Rodman & Renshaw LLC

                          Deal Size : $19.2 million

                          Deal Type : Public Offering

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                          09

                          ChemOutsourcing
                          Not Confirmed
                          ChemOutsourcing
                          Not Confirmed

                          Details : MNPR-101-Zr is a radioactive large molecule drug candidate, which is currently being evaluated for the treatment of uPAR-expressing triple-negative breast cancer.

                          Product Name : Undisclosed

                          Product Type : Antibody

                          Upfront Cash : Inapplicable

                          October 04, 2024

                          Lead Product(s) : MNPR-101-Zr

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          10

                          ChemOutsourcing
                          Not Confirmed
                          ChemOutsourcing
                          Not Confirmed

                          Details : Undisclosed

                          Product Name : Undisclosed

                          Product Type : Radiolabeled Compounds

                          Upfront Cash : Inapplicable

                          September 27, 2024

                          Lead Product(s) : 177-Lu MNPR-101-PCTA

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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