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Find Clinical Drug Pipeline Developments & Deals by Miragen Therapeutics

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                          Therapeutic Area by Lead Product

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                          Top Deals by Deal Size (USD bn)

                          01

                          IPEC-Americas
                          Not Confirmed
                          IPEC-Americas
                          Not Confirmed

                          Details : Company plans to use private placement financing proceeds of $91 million to advance multiple compounds through phase 2 proof of concept studies in TED and to expand its orphan disease pipeline.

                          Product Name : AVE-1642

                          Product Type : Antibody

                          Upfront Cash : Undisclosed

                          October 28, 2020

                          Lead Product(s) : VRDN-001

                          Therapeutic Area : Immunology

                          Highest Development Status : IND Enabling

                          Sponsor : Fairmount Funds Management LLC

                          Deal Size : $91.0 million

                          Deal Type : Financing

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                          02

                          IPEC-Americas
                          Not Confirmed
                          IPEC-Americas
                          Not Confirmed

                          Details : Data demonstrate that a single systemic dose of MRG-110 reduced detectable miR-92a levels in the peripheral blood of humans and led to the regulation of several well established miR-92a target genes.

                          Product Name : MRG-110

                          Product Type : Oligonucleotide

                          Upfront Cash : Inapplicable

                          July 28, 2020

                          Lead Product(s) : MRG-110

                          Therapeutic Area : Cardiology/Vascular Diseases

                          Highest Development Status : Phase I

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          03

                          IPEC-Americas
                          Not Confirmed
                          IPEC-Americas
                          Not Confirmed

                          Details : Cobomarsen is an inhibitor of miR-155 currently being developed by miRagen in two clinical programs to address different types of T-cell lymphoma, including a Phase 2 trial for cutaneous T-cell lymphoma (CTCL) and a Phase 1 trial for adult T-cell leukemi...

                          Product Name : MRG-106

                          Product Type : Other Small Molecule

                          Upfront Cash : Inapplicable

                          July 23, 2020

                          Lead Product(s) : Cobomarsen

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase II

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          04

                          IPEC-Americas
                          Not Confirmed
                          IPEC-Americas
                          Not Confirmed

                          Details : MRG-229 has demonstrated mechanistic biomarker regulation and antifibrotic activity in vitro using human model systems.

                          Product Name : MRG-229

                          Product Type : Cell and Gene therapy

                          Upfront Cash : Inapplicable

                          June 22, 2020

                          Lead Product(s) : MRG-229

                          Therapeutic Area : Pulmonary/Respiratory Diseases

                          Highest Development Status : Preclinical

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          05

                          IPEC-Americas
                          Not Confirmed
                          IPEC-Americas
                          Not Confirmed

                          Details : Cobomarsen lacks a compelling result for the study's primary endpoint, objective skin response of at least four months duration (ORR4) relative to the vorinostat control arm.

                          Product Name : MRG-106

                          Product Type : Other Small Molecule

                          Upfront Cash : Inapplicable

                          May 10, 2020

                          Lead Product(s) : Cobomarsen

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase II

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          06

                          IPEC-Americas
                          Not Confirmed
                          IPEC-Americas
                          Not Confirmed

                          Details : miRagen Therapeutics is conducting a Phase 1 trial of cobomarsen in adult T-cell leukemia/lymphoma (ATLL).

                          Product Name : MRG-106

                          Product Type : Other Small Molecule

                          Upfront Cash : Inapplicable

                          January 23, 2020

                          Lead Product(s) : Cobomarsen

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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