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    [{"orgOrder":0,"company":"Medis","sponsor":"Lupin Ltd","pharmaFlowCategory":"D","therapeuticArea":"Genetic Disease","country":"SLOVENIA","productType":"Other Small Molecule","year":"2022","type":"Agreement","leadProduct":"Mexiletine","moa":"||Na channel-alpha-subunit","graph1":"Genetic Disease","graph2":"Approved FDF","graph3":"Medis","amount2":0,"highestDevelopmentShortName":"Approved FDF","therapeuticAreaShortName":"Genetic Disease","amount2New":0,"dosageForm":"Oral Capsule","sponsorNew":"Medis \/ Lupin Ltd","highestDevelopmentStatusID":"15","companyTruncated":"Medis \/ Lupin Ltd"},{"orgOrder":0,"company":"Lupin Ltd","sponsor":"AVAS Pharmaceuticals","pharmaFlowCategory":"DU","therapeuticArea":"Genetic Disease","country":"INDIA","productType":"Other Small Molecule","year":"2025","type":"Inapplicable","leadProduct":"Mexiletine","moa":"||Na channel-alpha-subunit","graph1":"Genetic Disease","graph2":"Approved FDF","graph3":"Lupin Ltd","amount2":0,"highestDevelopmentShortName":"Approved FDF","therapeuticAreaShortName":"Genetic Disease","amount2New":0,"dosageForm":"Oral Capsule","sponsorNew":"Lupin Ltd \/ AVAS Pharmaceuticals","highestDevelopmentStatusID":"15","companyTruncated":"Lupin Ltd \/ AVAS Pharmaceuticals"},{"orgOrder":0,"company":"Lupin Ltd","sponsor":"Celnova Pharma","pharmaFlowCategory":"D","therapeuticArea":"Genetic Disease","country":"INDIA","productType":"Other Small Molecule","year":"2024","type":"Agreement","leadProduct":"Mexiletine","moa":"||Na channel-alpha-subunit","graph1":"Genetic Disease","graph2":"Approved FDF","graph3":"Lupin Ltd","amount2":0,"highestDevelopmentShortName":"Approved FDF","therapeuticAreaShortName":"Genetic Disease","amount2New":0,"dosageForm":"Oral Capsule","sponsorNew":"Lupin Ltd \/ Celnova Pharma","highestDevelopmentStatusID":"15","companyTruncated":"Lupin Ltd \/ Celnova Pharma"},{"orgOrder":0,"company":"Lannett Company, Inc.","sponsor":"RIVOPHARM SA","pharmaFlowCategory":"D","therapeuticArea":"Cardiology\/Vascular Diseases","country":"U.S.A","productType":"Other Small Molecule","year":"2020","type":"Collaboration","leadProduct":"Mexiletine","moa":"||Na channel-alpha-subunit","graph1":"Cardiology\/Vascular Diseases","graph2":"Approved FDF","graph3":"Lannett Company, Inc.","amount2":0,"highestDevelopmentShortName":"Approved FDF","therapeuticAreaShortName":"Cardiovascular Diseases","amount2New":0,"dosageForm":"Oral Capsule","sponsorNew":"Lannett Company, Inc. \/ RIVOPHARM SA","highestDevelopmentStatusID":"15","companyTruncated":"Lannett Company, Inc. \/ RIVOPHARM SA"},{"orgOrder":0,"company":"Lupin Ltd","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Genetic Disease","country":"INDIA","productType":"Other Small Molecule","year":"2021","type":"Inapplicable","leadProduct":"Mexiletine","moa":"||Sodium channel alpha subunit","graph1":"Genetic Disease","graph2":"Phase III","graph3":"Lupin Ltd","amount2":0,"highestDevelopmentShortName":"Ph III","therapeuticAreaShortName":"Genetic Disease","amount2New":0,"dosageForm":"Oral Capsule","sponsorNew":"Lupin Ltd \/ Inapplicable","highestDevelopmentStatusID":"10","companyTruncated":"Lupin Ltd \/ Inapplicable"},{"orgOrder":0,"company":"Lupin Ltd","sponsor":"Lupin Ltd","pharmaFlowCategory":"DU","therapeuticArea":"Genetic Disease","country":"INDIA","productType":"Other Small Molecule","year":"2024","type":"Inapplicable","leadProduct":"Mexiletine","moa":"||Sodium channel alpha subunit","graph1":"Genetic Disease","graph2":"Phase III","graph3":"Lupin Ltd","amount2":0,"highestDevelopmentShortName":"Ph III","therapeuticAreaShortName":"Genetic Disease","amount2New":0,"dosageForm":"Oral Suspension","sponsorNew":"Lupin Ltd \/ Lupin Ltd","highestDevelopmentStatusID":"10","companyTruncated":"Lupin Ltd \/ Lupin Ltd"},{"orgOrder":0,"company":"Lupin Ltd","sponsor":"Lupin Ltd","pharmaFlowCategory":"DU","therapeuticArea":"Genetic Disease","country":"INDIA","productType":"Other Small Molecule","year":"2024","type":"Inapplicable","leadProduct":"Mexiletine","moa":"||Sodium channel alpha subunit","graph1":"Genetic Disease","graph2":"Phase III","graph3":"Lupin Ltd","amount2":0,"highestDevelopmentShortName":"Ph III","therapeuticAreaShortName":"Genetic Disease","amount2New":0,"dosageForm":"Oral Suspension","sponsorNew":"Lupin Ltd \/ Lupin Ltd","highestDevelopmentStatusID":"10","companyTruncated":"Lupin Ltd \/ Lupin Ltd"},{"orgOrder":0,"company":"Lupin Ltd","sponsor":"Exeltis","pharmaFlowCategory":"D","therapeuticArea":"Genetic Disease","country":"INDIA","productType":"Other Small Molecule","year":"2020","type":"Agreement","leadProduct":"Mexiletine","moa":"||Na channel-alpha-subunit","graph1":"Genetic Disease","graph2":"Approved FDF","graph3":"Lupin Ltd","amount2":0,"highestDevelopmentShortName":"Approved FDF","therapeuticAreaShortName":"Genetic Disease","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"Lupin Ltd \/ Exeltis","highestDevelopmentStatusID":"15","companyTruncated":"Lupin Ltd \/ Exeltis"},{"orgOrder":0,"company":"Lupin Ltd","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Genetic Disease","country":"INDIA","productType":"Other Small Molecule","year":"2020","type":"Inapplicable","leadProduct":"Mexiletine","moa":"||Sodium channel alpha subunit","graph1":"Genetic Disease","graph2":"Phase III","graph3":"Lupin Ltd","amount2":0,"highestDevelopmentShortName":"Ph III","therapeuticAreaShortName":"Genetic Disease","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"Lupin Ltd \/ Inapplicable","highestDevelopmentStatusID":"10","companyTruncated":"Lupin Ltd \/ Inapplicable"},{"orgOrder":0,"company":"Lupin Ltd","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Musculoskeletal","country":"INDIA","productType":"Other Small Molecule","year":"2020","type":"Inapplicable","leadProduct":"Mexiletine","moa":"||Sodium channel alpha subunit","graph1":"Musculoskeletal","graph2":"Undisclosed","graph3":"Lupin Ltd","amount2":0,"highestDevelopmentShortName":"Undisclosed","therapeuticAreaShortName":"Musculoskeletal","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"Lupin Ltd \/ Inapplicable","highestDevelopmentStatusID":"1","companyTruncated":"Lupin Ltd \/ Inapplicable"},{"orgOrder":0,"company":"Grete Andersen, MD","sponsor":"GCP-Copenhagen | Region Capital Denmark | Danish Region | Lupin Ltd | ZiteLab","pharmaFlowCategory":"DU","therapeuticArea":"Genetic Disease","country":"","productType":"Other Small Molecule","year":"2022","type":"Inapplicable","leadProduct":"Lamotrigine","moa":"||Sodium channel alpha subunit","graph1":"Genetic Disease","graph2":"Undisclosed","graph3":"Grete Andersen, MD","amount2":0,"highestDevelopmentShortName":"Undisclosed","therapeuticAreaShortName":"Genetic Disease","amount2New":0,"dosageForm":"Tablet","sponsorNew":"Grete Andersen, MD \/ GCP-Copenhagen | Region Capital Denmark | Danish Region | Lupin Ltd | ZiteLab","highestDevelopmentStatusID":"1","companyTruncated":"Grete Andersen, MD \/ GCP-Copenhagen | Region Capital Denmark | Danish Region | Lupin Ltd | ZiteLab"}]

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                            01

                            Lupin Ltd

                            India arrow
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                            Lupin Ltd

                            India arrow
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                            Lead Product(s) : Mexiletine,Inapplicable

                            Therapeutic Area : Genetic Disease

                            Study Phase : Approved FDF

                            Sponsor : AVAS Pharmaceuticals

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Lupin and Avas Launch NaMuscla in Italy

                            Details : NaMuscla (mexiletine hydrochloride) is a Sodium channel alpha subunit blocker, being evaluated for the symptomatic treatment of myotonia in adults with non-dystrophic myotonic (NDM) disorders.

                            Product Name : Namuscla

                            Product Type : Other Small Molecule

                            Upfront Cash : Inapplicable

                            January 28, 2025

                            Lead Product(s) : Mexiletine,Inapplicable

                            Therapeutic Area : Genetic Disease

                            Highest Development Status : Approved FDF

                            Sponsor : AVAS Pharmaceuticals

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            02

                            Lupin Ltd

                            India arrow
                            EPSC
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                            Lupin Ltd

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                            EPSC
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                            Lead Product(s) : Mexiletine,Inapplicable

                            Therapeutic Area : Genetic Disease

                            Study Phase : Approved FDF

                            Sponsor : Celnova Pharma

                            Deal Size : Undisclosed

                            Deal Type : Agreement

                            DEALS_DEV arrow-down

                            Lupin Signs Pact with Celnova for Drug Distribution in South America

                            Details : Celnova will commercialise NaMuscla (mexiletine hydrochloride) in Argentina and Colombia, for the symptomatic treatment of myotonia in adults with non-dystrophic myotonic (NDM) disorders.

                            Product Name : NaMuscla

                            Product Type : Other Small Molecule

                            Upfront Cash : Undisclosed

                            September 27, 2024

                            Lead Product(s) : Mexiletine,Inapplicable

                            Therapeutic Area : Genetic Disease

                            Highest Development Status : Approved FDF

                            Sponsor : Celnova Pharma

                            Deal Size : Undisclosed

                            Deal Type : Agreement

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                            03

                            Lupin Ltd

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                            EPSC
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                            Lupin Ltd

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                            Lead Product(s) : Mexiletine,Inapplicable

                            Therapeutic Area : Genetic Disease

                            Study Phase : Phase III

                            Sponsor : Lupin Ltd

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            An Open-Label Extension Study to Evaluate the Long-Term Safety and Efficacy of Once Daily Mexiletine PR in Pat...

                            Details : Undisclosed

                            Product Name : Undisclosed

                            Product Type : Other Small Molecule

                            Upfront Cash : Inapplicable

                            August 12, 2024

                            Lead Product(s) : Mexiletine,Inapplicable

                            Therapeutic Area : Genetic Disease

                            Highest Development Status : Phase III

                            Sponsor : Lupin Ltd

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            04

                            Lupin Ltd

                            India arrow
                            EPSC
                            Not Confirmed

                            Lupin Ltd

                            India arrow
                            EPSC
                            Not Confirmed
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                            Lead Product(s) : Mexiletine,Inapplicable

                            Therapeutic Area : Genetic Disease

                            Study Phase : Phase III

                            Sponsor : Lupin Ltd

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            The Efficacy and Safety of Once Daily Mexiletine PR in Patients With Myotonic Dystrophy Type 1 and Type 2

                            Details : Undisclosed

                            Product Name : Undisclosed

                            Product Type : Other Small Molecule

                            Upfront Cash : Inapplicable

                            July 26, 2024

                            Lead Product(s) : Mexiletine,Inapplicable

                            Therapeutic Area : Genetic Disease

                            Highest Development Status : Phase III

                            Sponsor : Lupin Ltd

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            05

                            Grete Andersen, MD

                            Country arrow
                            EPSC
                            Not Confirmed

                            Grete Andersen, MD

                            Country arrow
                            EPSC
                            Not Confirmed
                            • fda
                            • EDQM
                            • WHO-GMP
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                            Lead Product(s) : Lamotrigine,Mexiletine

                            Therapeutic Area : Genetic Disease

                            Study Phase : Undisclosed

                            Sponsor : GCP-Copenhagen | Region Capital Denmark | Danish Region | Lupin Ltd | ZiteLab

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Treatment of Myotonia - Lamotrigine Versus Namuscla

                            Details : Undisclosed

                            Product Name : Undisclosed

                            Product Type : Other Small Molecule

                            Upfront Cash : Inapplicable

                            December 06, 2022

                            Lead Product(s) : Lamotrigine,Mexiletine

                            Therapeutic Area : Genetic Disease

                            Highest Development Status : Undisclosed

                            Sponsor : GCP-Copenhagen | Region Capital Denmark | Danish Region | Lupin Ltd | ZiteLab

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            06

                            Medis

                            Slovenia arrow
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                            Medis

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                            Lead Product(s) : Mexiletine,Inapplicable

                            Therapeutic Area : Genetic Disease

                            Study Phase : Approved FDF

                            Sponsor : Lupin Ltd

                            Deal Size : Undisclosed

                            Deal Type : Agreement

                            DEALS_DEV arrow-down

                            Lupin Signs Distribution Agreement with Medis for Orphan Drug NaMuscla®

                            Details : Under the agreement announced today, Medis will initially focus on the commercialization of NaMuscla® in the Central and East European countries, namely Croatia, Czech Republic, Hungary, Slovakia, and Slovenia in the first phase.

                            Product Name : NaMuscla

                            Product Type : Other Small Molecule

                            Upfront Cash : Undisclosed

                            September 02, 2022

                            Lead Product(s) : Mexiletine,Inapplicable

                            Therapeutic Area : Genetic Disease

                            Highest Development Status : Approved FDF

                            Sponsor : Lupin Ltd

                            Deal Size : Undisclosed

                            Deal Type : Agreement

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                            07

                            Lupin Ltd

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                            EPSC
                            Not Confirmed

                            Lupin Ltd

                            India arrow
                            EPSC
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                            Lead Product(s) : Mexiletine,Inapplicable

                            Therapeutic Area : Genetic Disease

                            Study Phase : Phase III

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Study to Investigate the Efficacy and Safety of Mexiletine in Patients With Myotonic Dystrophy Type 1 and Type...

                            Details : Undisclosed

                            Product Name : Undisclosed

                            Product Type : Other Small Molecule

                            Upfront Cash : Inapplicable

                            January 07, 2021

                            Lead Product(s) : Mexiletine,Inapplicable

                            Therapeutic Area : Genetic Disease

                            Highest Development Status : Phase III

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            08

                            Lupin Ltd

                            India arrow
                            EPSC
                            Not Confirmed

                            Lupin Ltd

                            India arrow
                            EPSC
                            Not Confirmed
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                            • EDQM
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                            Lead Product(s) : Mexiletine,Inapplicable

                            Therapeutic Area : Genetic Disease

                            Study Phase : Phase III

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Open Label Study in Adolescents and Children With Myotonic Disorders

                            Details : Undisclosed

                            Product Name : Undisclosed

                            Product Type : Other Small Molecule

                            Upfront Cash : Inapplicable

                            November 12, 2020

                            Lead Product(s) : Mexiletine,Inapplicable

                            Therapeutic Area : Genetic Disease

                            Highest Development Status : Phase III

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            09

                            Lupin Ltd

                            India arrow
                            EPSC
                            Not Confirmed

                            Lupin Ltd

                            India arrow
                            EPSC
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                            Lead Product(s) : Mexiletine,Inapplicable

                            Therapeutic Area : Musculoskeletal

                            Study Phase : Undisclosed

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Open-label Extension Study in Paediatric Patients Who Have Completed the MEX-NM-301 Study.

                            Details : Undisclosed

                            Product Name : Undisclosed

                            Product Type : Other Small Molecule

                            Upfront Cash : Inapplicable

                            November 10, 2020

                            Lead Product(s) : Mexiletine,Inapplicable

                            Therapeutic Area : Musculoskeletal

                            Highest Development Status : Undisclosed

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            10

                            Lannett Company, Inc.

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                            EPSC
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                            Lannett Company, Inc.

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                            Lead Product(s) : Mexiletine,Inapplicable

                            Therapeutic Area : Cardiology/Vascular Diseases

                            Study Phase : Approved FDF

                            Sponsor : RIVOPHARM SA

                            Deal Size : Undisclosed

                            Deal Type : Collaboration

                            DEALS_DEV arrow-down

                            Lannett Launches Mexiletine HCl Capsules

                            Details : Under the agreement, Lannett will primarily provide sales, marketing and distribution support for the product, for which it will receive a percentage of net profits. Other financial terms were not disclosed.

                            Product Name : Undisclosed

                            Product Type : Other Small Molecule

                            Upfront Cash : Undisclosed

                            July 23, 2020

                            Lead Product(s) : Mexiletine,Inapplicable

                            Therapeutic Area : Cardiology/Vascular Diseases

                            Highest Development Status : Approved FDF

                            Sponsor : RIVOPHARM SA

                            Deal Size : Undisclosed

                            Deal Type : Collaboration

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