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(alpha\/delta\/epsilon) | DNA | RNA","graph1":"Oncology","graph2":"Phase III","graph3":"Children's Oncology Group","amount2":0,"highestDevelopmentShortName":"Ph III","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"Children's Oncology Group \/ Geron | National Cancer Institute","highestDevelopmentStatusID":"10","companyTruncated":"Children's Oncology Group \/ Geron | National Cancer Institute"},{"orgOrder":0,"company":"Ono Pharmaceutical","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"JAPAN","productType":"Other Small Molecule","year":"2024","type":"Inapplicable","leadProduct":"Methotrexate","moa":"||Tyrosine-protein kinase BTK","graph1":"Oncology","graph2":"Phase I","graph3":"Ono Pharmaceutical","amount2":0,"highestDevelopmentShortName":"Ph I","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"Ono Pharmaceutical \/ 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                          Therapeutic Area by Lead Product

                          Study Phase by Lead Product

                          Company by Lead Product

                          Top Deals by Deal Size (USD bn)

                          01

                          Lead Product(s) : Methotrexate,Inapplicable

                          Therapeutic Area : Dermatology

                          Study Phase : Phase III

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

                          Details : Undisclosed

                          Product Name : Undisclosed

                          Product Type : Other Small Molecule

                          Upfront Cash : Inapplicable

                          February 02, 2024

                          Lead Product(s) : Methotrexate,Inapplicable

                          Therapeutic Area : Dermatology

                          Highest Development Status : Phase III

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

                          Company Banner

                          02

                          Lead Product(s) : Methotrexate,Inapplicable

                          Therapeutic Area : Immunology

                          Study Phase : Approved FDF

                          Sponsor : Eisai

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

                          Details : Primary endpoint of ACR20 response* at 12 weeks was 59.6% in Metoject (Methotrexate) group versus 51.0% in oral MTX group, indicating comparable efficacy. Adverse drug reaction incidence rates in this trial were 25.0% in the Metoject group and 34.0% in t...

                          Product Name : Metoject

                          Product Type : Other Small Molecule

                          Upfront Cash : Inapplicable

                          September 26, 2022

                          Lead Product(s) : Methotrexate,Inapplicable

                          Therapeutic Area : Immunology

                          Highest Development Status : Approved FDF

                          Sponsor : Eisai

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

                          Company Banner

                          03

                          Details : Discovered and developed by AbbVie scientists, RINVOQ is an oral, once daily, selective and reversible JAK inhibitor studied in several immune-mediated inflammatory diseases. It was engineered to have greater inhibitory potency for JAK1 versus JAK2, JAK3...

                          Product Name : Rinvoq

                          Product Type : Other Small Molecule

                          Upfront Cash : Inapplicable

                          March 17, 2021

                          Lead Product(s) : Upadacitinib,Methotrexate

                          Therapeutic Area : Immunology

                          Highest Development Status : Approved FDF

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

                          Abbvie Company Banner

                          04

                          Details : RINVOQ (15 mg, once daily) is the first oral, once-daily, selective and reversible JAK inhibitor approved for three adult rheumatic indications in the European Union: rheumatoid arthritis, psoriatic arthritis and ankylosing spondylitis.

                          Product Name : Rinvoq

                          Product Type : Other Small Molecule

                          Upfront Cash : Inapplicable

                          January 25, 2021

                          Lead Product(s) : Upadacitinib,Methotrexate

                          Therapeutic Area : Immunology

                          Highest Development Status : Approved FDF

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

                          Abbvie Company Banner

                          05

                          Details : In its guidance, NICE recommends upadacitinib, in combination with methotrexate for people with severe active RA, where their disease has responded inadequately to, or they are intolerant to at least two conventional disease-modifying anti-rheumatic drug...

                          Product Name : Rinvoq

                          Product Type : Other Small Molecule

                          Upfront Cash : Inapplicable

                          June 11, 2020

                          Lead Product(s) : Upadacitinib,Methotrexate

                          Therapeutic Area : Immunology

                          Highest Development Status : Approved FDF

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

                          Abbvie Company Banner

                          06

                          Details : Long-term results from the SELECT-COMPARE and SELECT MONOTHERAPY studies showed that RINVOQ™ (upadacitinib, 15 mg) continued to improve signs and symptoms in patients with rheumatoid arthritis through 72 and 84 weeks, respectively.

                          Product Name : Rinvoq

                          Product Type : Other Small Molecule

                          Upfront Cash : Inapplicable

                          April 06, 2020

                          Lead Product(s) : Upadacitinib,Methotrexate

                          Therapeutic Area : Immunology

                          Highest Development Status : Approved FDF

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

                          Abbvie Company Banner

                          09

                          Details : Undisclosed

                          Product Name : Undisclosed

                          Product Type : Other Small Molecule

                          Upfront Cash : Inapplicable

                          June 27, 2016

                          Lead Product(s) : Methotrexate,Adalimumab

                          Therapeutic Area : Immunology

                          Highest Development Status : Phase IV

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

                          Abbvie Company Banner

                          10

                          Lead Product(s) : ALX-0061,Methotrexate

                          Therapeutic Area : Immunology

                          Study Phase : Phase II

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

                          Details : Undisclosed

                          Product Name : Undisclosed

                          Product Type : Antibody

                          Upfront Cash : Inapplicable

                          December 05, 2014

                          Lead Product(s) : ALX-0061,Methotrexate

                          Therapeutic Area : Immunology

                          Highest Development Status : Phase II

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

                          Sanofi Company Banner