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    [{"orgOrder":0,"company":"Metacrine","sponsor":"Not Applicable","pharmaFlowCategory":"DU","amount":"Not Applicable","upfrontCash":"Not Applicable","newsHeadline":"Metacrine Demonstrates Best-in-Class FXR Drug Program with Positive Clinical Results in NASH Patients","therapeuticArea":"Hepatology (Liver, Pancreatic, Gall Bladder)","highestDevelopmentStatus":"Phase I","country":"U.S.A","productType":"Small molecule","productStatus":"New Molecular Entity","date":"January 2020","url1":"","url2":"","graph1":"Hepatology (Liver, Pancreatic, Gall Bladder)","graph2":"Phase I"},{"orgOrder":0,"company":"Metacrine","sponsor":"Not Applicable","pharmaFlowCategory":"DU","amount":"Not Applicable","upfrontCash":"Not Applicable","newsHeadline":"Metacrine Announces MET409 Receives FDA Fast Track Designation for the Treatment of NASH","therapeuticArea":"Hepatology (Liver, Pancreatic, Gall Bladder)","highestDevelopmentStatus":"Phase I","country":"U.S.A","productType":"Small 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molecule","productStatus":"New Molecular Entity","date":"September 2022","url1":"","url2":"","graph1":"Hepatology (Liver, Pancreatic, Gall Bladder)","graph2":"Phase II"},{"orgOrder":0,"company":"Metacrine","sponsor":"Equillium","pharmaFlowCategory":"D","amount":"$59.0 million","upfrontCash":"Undisclosed","newsHeadline":"Equillium and Metacrine Mutually Agree to Terminate Definitive Merger Agreement","therapeuticArea":"Gastroenterology","highestDevelopmentStatus":"Phase II","country":"U.S.A","productType":"Small molecule","productStatus":"New Molecular Entity","date":"December 2022","url1":"","url2":"","graph1":"Gastroenterology","graph2":"Phase II"}]

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              Metacrine

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              Equillium and Metacrine Mutually Agree to Terminate Definitive Merger Agreement

              Details:

              MET642, a potent, sustained, non-bile acid farnesoid x-receptor (FXR) agonist, is a non-immunosuppressive treatment for inflammatory bowel disease, including ulcerative colitis and Crohn’s disease.

              Lead Product(s): MET642

              Therapeutic Area: Gastroenterology Product Name: MET642

              Highest Development Status: Phase II Product Type: Small molecule

              Recipient: Equillium

              Deal Size: $59.0 million Upfront Cash: Undisclosed

              Deal Type: Termination December 23, 2022

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              Metacrine

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              Equillium to Acquire Metacrine in All-Stock Transaction

              Details:

              Through the acquisition, Equillium adds Metacrine’s farnesoid X receptor platform, including lead molecule MET642, an orally delivered FXR agonist that is a non-immunosuppressive treatment for inflammatory bowel disease, including ulcerative colitis and Crohn’s disease.

              Lead Product(s): MET642

              Therapeutic Area: Hepatology (Liver, Pancreatic, Gall Bladder) Product Name: MET642

              Highest Development Status: Phase II Product Type: Small molecule

              Partner/Sponsor/Collaborator: Equillium

              Deal Size: $59.0 million Upfront Cash: Undisclosed

              Deal Type: Acquisition September 06, 2022

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              Metacrine

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              Metacrine to Present New Preclinical Data in Inflammatory Bowel Disease at ECCO 2021 Virtual Congress

              Details:

              The Company’s two product candidates, MET409 and MET642, are currently being investigated in clinical trials as potential new treatments for NASH.

              Lead Product(s): MET409

              Therapeutic Area: Gastroenterology Product Name: MET409

              Highest Development Status: Preclinical Product Type: Small molecule

              Partner/Sponsor/Collaborator: Not Applicable

              Deal Size: Not Applicable Upfront Cash: Not Applicable

              Deal Type: Not Applicable July 06, 2021

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              Metacrine

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              Metacrine and Its Partners to Present Data at the EASL International Liver Congress™ 2021

              Details:

              MET642, an FXR Agonist with a Unique Chemotype is currently being investigated in clinical trials as potential new treatments for non-alcoholic steatohepatitis.

              Lead Product(s): MET642

              Therapeutic Area: Hepatology (Liver, Pancreatic, Gall Bladder) Product Name: MET642

              Highest Development Status: Phase II Product Type: Small molecule

              Partner/Sponsor/Collaborator: Not Applicable

              Deal Size: Not Applicable Upfront Cash: Not Applicable

              Deal Type: Not Applicable June 17, 2021

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              Metacrine

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              Metacrine Achieves Enrollment Target for MET642 Phase 2a Trial Interim Analysis

              Details:

              The Phase 2a study is a 16-week, randomized, placebo-controlled, multi-center trial evaluating the safety, tolerability and pharmacological activity of MET642 (3 mg and 6 mg). Full trial results of up to 180 patients are expected to be reported in the first half of 2022.

              Lead Product(s): MET642

              Therapeutic Area: Hepatology (Liver, Pancreatic, Gall Bladder) Product Name: MET642

              Highest Development Status: Phase II Product Type: Small molecule

              Partner/Sponsor/Collaborator: Not Applicable

              Deal Size: Not Applicable Upfront Cash: Not Applicable

              Deal Type: Not Applicable May 18, 2021

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              Metacrine

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              Metacrine Initiates Phase 2a Trial of MET642 for the Treatment of Patients with NASH

              Details:

              First patient has been treated in its Phase 2a trial of MET642, a potent, sustained, non-bile acid farnesoid x-receptor (FXR) agonist, for the treatment of patients with non-alcoholic steatohepatitis (NASH).

              Lead Product(s): MET642

              Therapeutic Area: Hepatology (Liver, Pancreatic, Gall Bladder) Product Name: MET642

              Highest Development Status: Phase II Product Type: Small molecule

              Partner/Sponsor/Collaborator: Not Applicable

              Deal Size: Not Applicable Upfront Cash: Not Applicable

              Deal Type: Not Applicable March 09, 2021

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              Metacrine

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              Metacrine to Present New Data from MET409 Program in NASH at AASLD’s The Liver Meeting Digital Experience™

              Details:

              The findings showed robust and sustained FXR activation, which Metacrine believes is key to optimizing therapeutic benefits. Combined with a favorable pharmacological and tolerability profile, the results support the therapeutic potential of MET409 for patients with NASH.

              Lead Product(s): MET409

              Therapeutic Area: Hepatology (Liver, Pancreatic, Gall Bladder) Product Name: MET409

              Highest Development Status: Phase I Product Type: Small molecule

              Partner/Sponsor/Collaborator: Not Applicable

              Deal Size: Not Applicable Upfront Cash: Not Applicable

              Deal Type: Not Applicable October 01, 2020

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              Metacrine

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              Metacrine Presents Positive MET409 Phase 1b Clinical Data in NASH Patients at the Digital International Liver Congress™ 2020

              Details:

              MET409 demonstrated notable improvements in decreased liver fat content and differentiated impacts on pruritus and LDL cholesterol after 12 weeks of treatment in NASH patients .

              Lead Product(s): MET409

              Therapeutic Area: Hepatology (Liver, Pancreatic, Gall Bladder) Product Name: MET409

              Highest Development Status: Phase I Product Type: Small molecule

              Partner/Sponsor/Collaborator: Not Applicable

              Deal Size: Not Applicable Upfront Cash: Not Applicable

              Deal Type: Not Applicable August 27, 2020

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              Metacrine

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              Metacrine Announces MET409 Receives FDA Fast Track Designation for the Treatment of NASH

              Details:

              U.S. Food & Drug Administration (FDA) has granted Fast Track designation to MET409, the company’s lead farnesoid X receptor (FXR) agonist, for the treatment of non-alcoholic steatohepatitis (NASH).

              Lead Product(s): MET409

              Therapeutic Area: Hepatology (Liver, Pancreatic, Gall Bladder) Product Name: MET409

              Highest Development Status: Phase I Product Type: Small molecule

              Partner/Sponsor/Collaborator: Not Applicable

              Deal Size: Not Applicable Upfront Cash: Not Applicable

              Deal Type: Not Applicable August 25, 2020

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              Metacrine

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              Metacrine Demonstrates Best-in-Class FXR Drug Program with Positive Clinical Results in NASH Patients

              Details:

              Randomized, placebo-controlled 12-week study showed mean liver fat reduction of up to 55% with MET409

              Lead Product(s): MET409

              Therapeutic Area: Hepatology (Liver, Pancreatic, Gall Bladder) Product Name: Undisclosed

              Highest Development Status: Phase I Product Type: Small molecule

              Partner/Sponsor/Collaborator: Not Applicable

              Deal Size: Not Applicable Upfront Cash: Not Applicable

              Deal Type: Not Applicable January 22, 2020

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