
Year
DEALS // DEV.
Country
Therapeutic Area
Study Phase
Deal Type
Product Type
Dosage Form
Lead Product
Target

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Lead Product(s) : Undisclosed
Therapeutic Area : Oncology
Study Phase : Discovery Platform
Sponsor : EpimAb Biotherapeutics
Deal Size : Undisclosed
Deal Type : Partnership
Medigene & EpimAb Partner for TCR-Guided T Cell Engagers
Details : Through the partnership, both companies will focus on researching and developing off-the-shelf T cell receptor (TCR)-guided T Cell Engagers (TCR-TCEs) for the treatment of solid tumors.
Product Name : Undisclosed
Product Type : Undisclosed
Upfront Cash : Undisclosed
February 27, 2025
Lead Product(s) : Undisclosed
Therapeutic Area : Oncology
Highest Development Status : Discovery Platform
Sponsor : EpimAb Biotherapeutics
Deal Size : Undisclosed
Deal Type : Partnership

Details : MDG1015 is a Cell and Gene Therapy drug candidate, which is currently being evaluated in phase I clinical studies for the treatment of Carcinoma, Ovarian Epithelial.
Product Name : Undisclosed
Product Type : Cell & Gene Therapy
Upfront Cash : Inapplicable
December 27, 2024

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Lead Product(s) : Undisclosed
Therapeutic Area : Oncology
Study Phase : Phase I
Sponsor : Regeneron Pharmaceuticals
Deal Size : $1,015.0 million
Deal Type : Collaboration
Medigene Receives Milestone Payment from Regeneron Pharmaceuticals, Inc.
Details : Regeneron purchased the MAGE-A4-TCR program, a TCR that targets the MAGE-A4 protein in cancer cells, as part of its acquisition of 2seventy’s oncology and autoimmune pipeline.
Product Name : Undisclosed
Product Type : Undisclosed
Upfront Cash : $15.0 million
December 03, 2024
Lead Product(s) : Undisclosed
Therapeutic Area : Oncology
Highest Development Status : Phase I
Sponsor : Regeneron Pharmaceuticals
Deal Size : $1,015.0 million
Deal Type : Collaboration

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Lead Product(s) : MDG1015
Therapeutic Area : Oncology
Study Phase : IND Enabling
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable
Medigene Gets FDA Clearance for MDG1015, a TCR-T Therapy for Solid Tumors
Details : MDG1015 is a first-in-class, TCR-T therapy targeting NY-ESO-1/ LAGE-1a. It is being developed for gastric cancer, ovarian cancer, myxoid/round cell liposarcoma and synovial sarcoma.
Product Name : Undisclosed
Product Type : Cell & Gene Therapy
Upfront Cash : Inapplicable
September 05, 2024
Lead Product(s) : MDG1015
Therapeutic Area : Oncology
Highest Development Status : IND Enabling
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable

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Lead Product(s) : Undisclosed
Therapeutic Area : Oncology
Study Phase : Preclinical
Recipient : WuXi Biologics
Deal Size : Undisclosed
Deal Type : Collaboration
Medigene and WuXi Biologics Collaborate on Off-the-Shelf TCR-Guided T Cell Engagers
Details : The collaboration combines the respective expertise of each company with Medigene’s 3S TCR generation and WuXi Biologics’ unique anti-CD3 mAb for the treatment of cancers.
Product Name : Undisclosed
Product Type : Undisclosed
Upfront Cash : Undisclosed
August 08, 2024
Lead Product(s) : Undisclosed
Therapeutic Area : Oncology
Highest Development Status : Preclinical
Recipient : WuXi Biologics
Deal Size : Undisclosed
Deal Type : Collaboration

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Lead Product(s) : MDG2021,PD1-41BB
Therapeutic Area : Oncology
Study Phase : Preclinical
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable
Medigene Announces Lead Selection for KRAS-targeting TCR-T in Solid Tumors
Details : MDG2021, a TCR-T therapy targeting KRASG12D with HLA-A*11 being developed in combination with the Company’s PD1-41BB costimulatory switch protein, for solid tumors.
Product Name : Undisclosed
Product Type : Cell & Gene Therapy
Upfront Cash : Inapplicable
June 20, 2024
Lead Product(s) : MDG2021,PD1-41BB
Therapeutic Area : Oncology
Highest Development Status : Preclinical
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable

Medigene-BioNTech Collaboration Agreement Extended Beyond Initial Term
Details : The collaboration aims to advance T cell receptor immunotherapies against cancer
Product Name : Undisclosed
Product Type : Undisclosed
Upfront Cash : Undisclosed
May 21, 2024

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Lead Product(s) : MDG1015
Therapeutic Area : Oncology
Study Phase : Preclinical
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable
Medigene Selects Indication for 3rd Generation TCR-T Therapy in Solid Tumors
Details : MDG1015, a TCR-T therapy targeting NY-ESO-1/LAGE-1a, is in trials for gastric, ovarian cancers, and soft tissue sarcomas.
Product Name : Undisclosed
Product Type : Cell & Gene Therapy
Upfront Cash : Inapplicable
February 12, 2024
Lead Product(s) : MDG1015
Therapeutic Area : Oncology
Highest Development Status : Preclinical
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable

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Lead Product(s) : MDG1015,PD1-41BB
Therapeutic Area : Oncology
Study Phase : IND Enabling
Recipient : AGC Biologics
Deal Size : Undisclosed
Deal Type : Agreement
AGC Biologics Signs TCR-T Cell Services Agreement to Support Medigene’s New Cell Therapy Product
Details : Under the agreement, AGC Biologics is providing autologous production for MDG1015, a third generation TCR-T therapy, focused on the treatment of solid cancers, supporting Medigene’s IND filing and clinical trials.
Product Name : Undisclosed
Product Type : Cell & Gene Therapy
Upfront Cash : Undisclosed
October 25, 2023
Lead Product(s) : MDG1015,PD1-41BB
Therapeutic Area : Oncology
Highest Development Status : IND Enabling
Recipient : AGC Biologics
Deal Size : Undisclosed
Deal Type : Agreement

Details : MDG2011, a T cell receptor engineered T cell (TCR-T) therapy targeting KRAS (Kirsten rat sarcoma viral oncogene homologue) G12V with HLA-A*11 and being developed in combination with the Company’s PD1-41BB costimulatory switch protein (CSP) technology.
Product Name : Undisclosed
Product Type : Cell & Gene Therapy
Upfront Cash : Inapplicable
September 18, 2023
