
Year
DEALS // DEV.
Country
Therapeutic Area
Study Phase
Deal Type
Product Type
Dosage Form
Lead Product
Target

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Lead Product(s) : MTX-463
Therapeutic Area : Pulmonary/Respiratory Diseases
Study Phase : Phase II
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable
WISPer: Evaluation of MTX-463 in Participants With Idiopathic Pulmonary Fibrosis (IPF)
Details : MTX-463 is a Antibody drug candidate, which is currently being evaluated in phase II clinical studies for the treatment of Idiopathic Pulmonary Fibrosis.
Product Name : Undisclosed
Product Type : Antibody, Unconjugated
Upfront Cash : Inapplicable
May 13, 2025
Lead Product(s) : MTX-463
Therapeutic Area : Pulmonary/Respiratory Diseases
Highest Development Status : Phase II
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable

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Lead Product(s) : MTX-463
Therapeutic Area : Pulmonary/Respiratory Diseases
Study Phase : Phase I
Sponsor : Eli Lilly
Deal Size : $786.0 million
Deal Type : Licensing Agreement
Mediar Therapeutics Signs Global License with Lilly for WISP1 Antibody in IPF
Details : Under the licensing agreement, Lilly will have the right to lead all further clinical development and commercialization of the MTX-463 for treating idiopathic pulmonary fibrosis.
Product Name : Undisclosed
Product Type : Antibody, Unconjugated
Upfront Cash : Undisclosed
January 10, 2025
Lead Product(s) : MTX-463
Therapeutic Area : Pulmonary/Respiratory Diseases
Highest Development Status : Phase I
Sponsor : Eli Lilly
Deal Size : $786.0 million
Deal Type : Licensing Agreement

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Lead Product(s) : MTX-474
Therapeutic Area : Pulmonary/Respiratory Diseases
Study Phase : Phase I
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable
Mediar Therapeutics Starts Second Program of Antibodies to Halt Fibrosis
Details : MTX-474 is a first-in-class human IgG1 antibody designed to neutralize the EphrinB2 signaling that causes the onset and progression of fibrosis.
Product Name : Undisclosed
Product Type : Antibody, Unconjugated
Upfront Cash : Inapplicable
August 07, 2024
Lead Product(s) : MTX-474
Therapeutic Area : Pulmonary/Respiratory Diseases
Highest Development Status : Phase I
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable

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Lead Product(s) : MTX-474
Therapeutic Area : Undisclosed
Study Phase : Phase I
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable
A First-in-Human Safety Trial of MTX-474
Details : MTX-474 is a Antibody drug candidate, which is currently being evaluated in phase I clinical studies for the treatment of undefined medical condition.
Product Name : Undisclosed
Product Type : Antibody, Unconjugated
Upfront Cash : Inapplicable
August 02, 2024
Lead Product(s) : MTX-474
Therapeutic Area : Undisclosed
Highest Development Status : Phase I
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable

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Lead Product(s) : MTX-463
Therapeutic Area : Pulmonary/Respiratory Diseases
Study Phase : Phase I
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable
Mediar Advances Fibrosis To Clinic With First Cohort Dosing In Phase 1 Of MTX-463
Details : MTX-463 is an immunoglobin G1 (IgG1) monoclonal antibody directed against WNT-inducible signaling pathway protein 1 (WISP1). It is being evaluated for the treatment of idiopathic pulmonary fibrosis.
Product Name : Undisclosed
Product Type : Antibody, Unconjugated
Upfront Cash : Inapplicable
May 07, 2024
Lead Product(s) : MTX-463
Therapeutic Area : Pulmonary/Respiratory Diseases
Highest Development Status : Phase I
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable

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Lead Product(s) : MTX-463
Therapeutic Area : Undisclosed
Study Phase : Phase I
Sponsor : Icon Plc
Deal Size : Inapplicable
Deal Type : Inapplicable
A First-in-Human Safety Trial of MTX-463
Details : MTX-463 is a Antibody drug candidate, which is currently being evaluated in phase I clinical studies for the treatment of undefined medical condition.
Product Name : Undisclosed
Product Type : Antibody, Unconjugated
Upfront Cash : Inapplicable
May 06, 2024
Lead Product(s) : MTX-463
Therapeutic Area : Undisclosed
Highest Development Status : Phase I
Sponsor : Icon Plc
Deal Size : Inapplicable
Deal Type : Inapplicable

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Lead Product(s) : Undisclosed
Therapeutic Area : Trauma (Emergency, Injury, Surgery)
Study Phase : Preclinical
Sponsor : Novartis Venture Fund
Deal Size : $105.0 million
Deal Type : Financing
Details : The series A financing will support advancement of the company’s portfolio of first-in-class antibody treatments, which offer unique potential to address fibrosis at varying stages of the disease, with two programs advancing into human studies in 2024.
Product Name : Undisclosed
Product Type : Undisclosed
Upfront Cash : Undisclosed
March 15, 2023
Lead Product(s) : Undisclosed
Therapeutic Area : Trauma (Emergency, Injury, Surgery)
Highest Development Status : Preclinical
Sponsor : Novartis Venture Fund
Deal Size : $105.0 million
Deal Type : Financing

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Lead Product(s) : Undisclosed
Therapeutic Area : Trauma (Emergency, Injury, Surgery)
Study Phase : Discovery
Sponsor : Distributed Bio
Deal Size : Undisclosed
Deal Type : Partnership
Distributed Bio Partners With Mediar Therapeutics, Inc.
Details : Under the terms of this partnership, Distributed Bio will use its SuperHuman2.0 Antibody Discovery platform to identify lead antibodies for Mediar programs.
Product Name : Undisclosed
Product Type : Undisclosed
Upfront Cash : Undisclosed
June 03, 2020
Lead Product(s) : Undisclosed
Therapeutic Area : Trauma (Emergency, Injury, Surgery)
Highest Development Status : Discovery
Sponsor : Distributed Bio
Deal Size : Undisclosed
Deal Type : Partnership
