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MDR-101, is a single-dose cellular therapy derived from a living kidney donor’s blood. The therapy is designed to establish mixed chimerism, which occurs when a low level of donor blood cells remains in the blood of the kidney recipient after infusion of donor stem cells.
MDR-101 is a single-dose cellular therapy derived from a living kidney donor’s blood. This is the first randomized, multi-center pivotal study specifically designed to eliminate the use of immunosuppressive anti-rejection drugs following transplant.
MDR-101 is intended to induce donor-specific immune tolerance in order to avert transplant kidney rejection to minimize cumulative and serious side effects associated with immunosuppressive drugs.
The presentation will review the safety and efficacy of cellular immunotherapy with MDR-101 for induction of functional immune tolerance in recipients of human leukocyte antigen (HLA)-matched, living donor kidney transplants.
MDR-101 is being developed to avert transplant kidney rejection by the recipient’s immune system without the need for chronic use of immunosuppressive drugs.