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    [{"orgOrder":0,"company":"Repare Therapeutics","sponsor":"Canadian Cancer Trials Group","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"CANADA","productType":"Miscellaneous","year":"2023","type":"Inapplicable","leadProduct":"Lunresertib","moa":"PKMYT1","graph1":"Oncology","graph2":"Phase I","graph3":"Repare Therapeutics","amount2":0,"highestDevelopmentShortName":"Ph I","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Capsule","sponsorNew":"Repare Therapeutics \/ Canadian Cancer Trials Group","highestDevelopmentStatusID":"6","companyTruncated":"Repare Therapeutics \/ Canadian Cancer Trials Group"},{"orgOrder":0,"company":"Repare Therapeutics","sponsor":"Undisclosed","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"CANADA","productType":"Miscellaneous","year":"2021","type":"Inapplicable","leadProduct":"Lunresertib","moa":"PKMYT1","graph1":"Oncology","graph2":"Phase I","graph3":"Repare 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Therapeutics","amount2":0,"highestDevelopmentShortName":"Preclinical","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Capsule","sponsorNew":"Repare Therapeutics \/ Debiopharm","highestDevelopmentStatusID":"4","companyTruncated":"Repare Therapeutics \/ Debiopharm"}]

    Find Clinical Drug Pipeline Developments & Deals for Lunresertib

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                            01

                            Repare Therapeutics

                            Canada arrow
                            OTS 2025
                            Not Confirmed

                            Repare Therapeutics

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                            OTS 2025
                            Not Confirmed
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                            Lead Product(s) : Lunresertib,Camonsertib

                            Therapeutic Area : Oncology

                            Study Phase : Phase I

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Repare Therapeutics Announces Positive Results from Lunresertib, Camonsertib Combo Trial

                            Details : RP-6306 (lunresertib), a first-in-class, selective and potent oral small molecule inhibitor of PKMYT1, is being developed in combination with Camonsertib for the treatment of endometrial cancer.

                            Product Name : Undisclosed

                            Product Type : Miscellaneous

                            Upfront Cash : Inapplicable

                            December 12, 2024

                            Lead Product(s) : Lunresertib,Camonsertib

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase I

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            02

                            Repare Therapeutics

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                            OTS 2025
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                            Repare Therapeutics

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                            OTS 2025
                            Not Confirmed
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                            Lead Product(s) : Lunresertib,Camonsertib

                            Therapeutic Area : Oncology

                            Study Phase : Phase I

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Repare Shares Positive Phase 1 Data From MYTHIC Safety and Tolerability Study

                            Details : RP-6306 (lunresertib) in combination with RP-3500 (camonsertib) is being evaluated for the treatment of multiple advanced solid tumors types.

                            Product Name : Undisclosed

                            Product Type : Miscellaneous

                            Upfront Cash : Inapplicable

                            October 23, 2024

                            Lead Product(s) : Lunresertib,Camonsertib

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase I

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            03

                            Foundation Medicine

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                            OTS 2025
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                            Foundation Medicine

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                            OTS 2025
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                            Lead Product(s) : Lunresertib,Camonsertib

                            Therapeutic Area : Oncology

                            Study Phase : Phase I

                            Sponsor : Repare Therapeutics

                            Deal Size : Undisclosed

                            Deal Type : Collaboration

                            DEALS_DEV arrow-down

                            Foundation Medicine Partners with Repare for Genomic Profiling and Companion Diagnostic

                            Details : The collaboration aims to support Repare’s ongoing clinical development of RP-6306 (lunresertib) oral small molecule inhibitor of PKMYT1 alone or with camonsertib for the treatment of neoplasms.

                            Product Name : Undisclosed

                            Product Type : Miscellaneous

                            Upfront Cash : Undisclosed

                            June 12, 2024

                            Lead Product(s) : Lunresertib,Camonsertib

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase I

                            Sponsor : Repare Therapeutics

                            Deal Size : Undisclosed

                            Deal Type : Collaboration

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                            04

                            Repare Therapeutics

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                            OTS 2025
                            Not Confirmed

                            Repare Therapeutics

                            Canada arrow
                            OTS 2025
                            Not Confirmed
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                            Lead Product(s) : Lunresertib,Camonsertib

                            Therapeutic Area : Oncology

                            Study Phase : Phase I

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Repare's Lunresertib Gets FDA Fast Track for Platinum-Resistant Ovarian Cancer

                            Details : FDA granted Fast Track designation to RP-6306 (lunresertib) in combination with RP-3500 (camonsertib) for CCNE1 amplified, or FBXW7 or PPP2R1A-mutated platinum-resistant ovarian cancer.

                            Product Name : Undisclosed

                            Product Type : Miscellaneous

                            Upfront Cash : Inapplicable

                            June 04, 2024

                            Lead Product(s) : Lunresertib,Camonsertib

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase I

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            05

                            Repare Therapeutics

                            Canada arrow
                            OTS 2025
                            Not Confirmed

                            Repare Therapeutics

                            Canada arrow
                            OTS 2025
                            Not Confirmed
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                            Lead Product(s) : Lunresertib,Debio 0123

                            Therapeutic Area : Oncology

                            Study Phase : Phase I

                            Sponsor : Debiopharm

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Repare and Debiopharm Dosed First Patient in Phase 1/1b MYTHIC Trial

                            Details : RP-6306 (lunresertib), an oral PKMYT1 inhibitor, is being developed in combination with Debio 0123, a selective WEE1 kinase inhibitor, for treating advanced solid tumors.

                            Product Name : Undisclosed

                            Product Type : Miscellaneous

                            Upfront Cash : Inapplicable

                            April 30, 2024

                            Lead Product(s) : Lunresertib,Debio 0123

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase I

                            Sponsor : Debiopharm

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            06

                            Repare Therapeutics

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                            OTS 2025
                            Not Confirmed

                            Repare Therapeutics

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                            OTS 2025
                            Not Confirmed
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                            Lead Product(s) : Debio 0123,Lunresertib

                            Therapeutic Area : Oncology

                            Study Phase : Preclinical

                            Sponsor : Debiopharm

                            Deal Size : Undisclosed

                            Deal Type : Collaboration

                            DEALS_DEV arrow-down

                            Debiopharm Partners with Repare To Explore PKMYT1 and WEE1 Inhibition

                            Details : This collaboration will explore synergy between Debio 0123, a selective WEE1 inhibitor, and RP-6306 (lunresertib), a first-in-class small molecule with anticancer activity.

                            Product Name : Undisclosed

                            Product Type : Miscellaneous

                            Upfront Cash : Undisclosed

                            January 04, 2024

                            Lead Product(s) : Debio 0123,Lunresertib

                            Therapeutic Area : Oncology

                            Highest Development Status : Preclinical

                            Sponsor : Debiopharm

                            Deal Size : Undisclosed

                            Deal Type : Collaboration

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                            07

                            Repare Therapeutics

                            Canada arrow
                            OTS 2025
                            Not Confirmed

                            Repare Therapeutics

                            Canada arrow
                            OTS 2025
                            Not Confirmed
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                            Lead Product(s) : Lunresertib

                            Therapeutic Area : Oncology

                            Study Phase : Phase I

                            Sponsor : Canadian Cancer Trials Group

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Repare Therapeutics Reports Proof of Concept for Lunresertib (RP-6306) in Clinic, Initial Monotherapy Data fro...

                            Details : RP-6306 (lunresertib) is a PKMYT1 inhibitor currently in Phase 1 clinical development a potential leading ATR inhibitor currently in Phase 1/2 clinical development and partnered with Roche.

                            Product Name : Undisclosed

                            Product Type : Miscellaneous

                            Upfront Cash : Inapplicable

                            June 07, 2023

                            Lead Product(s) : Lunresertib

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase I

                            Sponsor : Canadian Cancer Trials Group

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            08

                            Repare Therapeutics

                            Canada arrow
                            OTS 2025
                            Not Confirmed

                            Repare Therapeutics

                            Canada arrow
                            OTS 2025
                            Not Confirmed
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                            Lead Product(s) : Lunresertib,Gemcitabine

                            Therapeutic Area : Oncology

                            Study Phase : Phase I

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Repare Therapeutics Announces Publication of Preclinical Data in Nature Demonstrating the Potential of PKMYT1 ...

                            Details : Preclinical data demonstrated inhibition of CCNE1-amplified tumor growth in vivo by selective inhibition of PKMYT1 using RP-6306 used CRISPR-based screening approach, to uncover CCNE1 amplification as synthetic lethal to PKMYT1 inhibition.

                            Product Name : Undisclosed

                            Product Type : Miscellaneous

                            Upfront Cash : Inapplicable

                            April 20, 2022

                            Lead Product(s) : Lunresertib,Gemcitabine

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase I

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            09

                            Repare Therapeutics

                            Canada arrow
                            OTS 2025
                            Not Confirmed

                            Repare Therapeutics

                            Canada arrow
                            OTS 2025
                            Not Confirmed
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                            Lead Product(s) : Lunresertib,Gemcitabine

                            Therapeutic Area : Oncology

                            Study Phase : Phase I

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Repare Therapeutics Doses First Patient in Phase 1 Clinical Trial of RP-6306 in Combination with Gemcitabine f...

                            Details : The first patient has been dosed in the company’s Phase 1 clinical trial of RP-6306, a first-in-class small molecule candidate targeting PKMYT1, in combination with gemcitabine for the treatment of molecularly selected advanced solid tumors.

                            Product Name : Undisclosed

                            Product Type : Miscellaneous

                            Upfront Cash : Inapplicable

                            December 21, 2021

                            Lead Product(s) : Lunresertib,Gemcitabine

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase I

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            10

                            Repare Therapeutics

                            Canada arrow
                            OTS 2025
                            Not Confirmed

                            Repare Therapeutics

                            Canada arrow
                            OTS 2025
                            Not Confirmed
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                            Lead Product(s) : Lunresertib

                            Therapeutic Area : Oncology

                            Study Phase : Phase I

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Repare Therapeutics Doses First Patient in Phase 1 Clinical Trial of RP-6306, a First-in-Class, Selective, Ora...

                            Details : RP-6306, a small molecule product candidate targeting PKMYT1, which is a novel target that Repare discovered to be synthetic lethal with CCNE1 amplification and other genomic mutations to treat CCNE1-amplified, FBXW7-altered and other PKMYT1 inhibitor-se...

                            Product Name : Undisclosed

                            Product Type : Miscellaneous

                            Upfront Cash : Inapplicable

                            May 03, 2021

                            Lead Product(s) : Lunresertib

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase I

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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