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    [{"orgOrder":0,"company":"Denovo Biopharma","sponsor":"Curia","pharmaFlowCategory":"DU","therapeuticArea":"Psychiatry\/Psychology","country":"U.S.A","productType":"Other Small Molecule","year":"2022","type":"Inapplicable","leadProduct":"Liafensine","moa":"Dopamine\/serotonin\/norepinephrine Reuptake","graph1":"Psychiatry\/Psychology","graph2":"Phase II","graph3":"Denovo Biopharma","amount2":0,"highestDevelopmentShortName":"Ph II","therapeuticAreaShortName":"Psychiatry","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"Denovo Biopharma \/ Curia","highestDevelopmentStatusID":"8","companyTruncated":"Denovo Biopharma \/ Curia"},{"orgOrder":0,"company":"Denovo Biopharma","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Psychiatry\/Psychology","country":"U.S.A","productType":"Other Small Molecule","year":"2024","type":"Inapplicable","leadProduct":"Liafensine","moa":"Dopamine\/serotonin\/norepinephrine Reuptake","graph1":"Psychiatry\/Psychology","graph2":"Phase II","graph3":"Denovo Biopharma","amount2":0,"highestDevelopmentShortName":"Ph II","therapeuticAreaShortName":"Psychiatry","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"Denovo Biopharma \/ Inapplicable","highestDevelopmentStatusID":"8","companyTruncated":"Denovo Biopharma \/ Inapplicable"},{"orgOrder":0,"company":"Denovo Biopharma","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Psychiatry\/Psychology","country":"U.S.A","productType":"Other Small Molecule","year":"2024","type":"Inapplicable","leadProduct":"Liafensine","moa":"Dopamine\/serotonin\/norepinephrine Reuptake","graph1":"Psychiatry\/Psychology","graph2":"Phase II","graph3":"Denovo Biopharma","amount2":0,"highestDevelopmentShortName":"Ph II","therapeuticAreaShortName":"Psychiatry","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"Denovo Biopharma \/ Inapplicable","highestDevelopmentStatusID":"8","companyTruncated":"Denovo Biopharma \/ Inapplicable"},{"orgOrder":0,"company":"Denovo Biopharma","sponsor":"Chuang Yi Global Asset Management","pharmaFlowCategory":"D","therapeuticArea":"Psychiatry\/Psychology","country":"U.S.A","productType":"Other Small Molecule","year":"2025","type":"Licensing Agreement","leadProduct":"Liafensine","moa":"Monoamine transporter","graph1":"Psychiatry\/Psychology","graph2":"Phase II","graph3":"Denovo Biopharma","amount2":0,"highestDevelopmentShortName":"Ph II","therapeuticAreaShortName":"Psychiatry","amount2New":0,"dosageForm":"Oral Tablet","sponsorNew":"Denovo Biopharma \/ Chuang Yi Global Asset Management","highestDevelopmentStatusID":"8","companyTruncated":"Denovo Biopharma \/ Chuang Yi Global Asset Management"}]

    Find Clinical Drug Pipeline Developments & Deals for Liafensine

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                            01

                            Denovo Biopharma

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                            ACS Fall 2025
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                            Denovo Biopharma

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                            ACS Fall 2025
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                            Lead Product(s) : Liafensine

                            Therapeutic Area : Psychiatry/Psychology

                            Study Phase : Phase II

                            Sponsor : Chuang Yi Global Asset Management

                            Deal Size : Undisclosed

                            Deal Type : Licensing Agreement

                            DEALS_DEV arrow-down

                            Denovo Out-Licenses DB104 for TRD to Chuang Yi in Taiwan

                            Details : Under the licensing agreement, CYMD will hold the exclusive rights to develop and commercialize DB104 (liafensine) in Taiwan, with Denovo maintaining worldwide rights outside of Taiwan

                            Product Name : DB104

                            Product Type : Other Small Molecule

                            Upfront Cash : Undisclosed

                            June 23, 2025

                            Lead Product(s) : Liafensine

                            Therapeutic Area : Psychiatry/Psychology

                            Highest Development Status : Phase II

                            Sponsor : Chuang Yi Global Asset Management

                            Deal Size : Undisclosed

                            Deal Type : Licensing Agreement

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                            02

                            Denovo Biopharma

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                            ACS Fall 2025
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                            Denovo Biopharma

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                            ACS Fall 2025
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                            Lead Product(s) : Liafensine

                            Therapeutic Area : Psychiatry/Psychology

                            Study Phase : Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            FDA Grants Fast Track For DB104 in Treatment-Resistant Depression

                            Details : DB104 (liafensine) is a first–in–class triple reuptake inhibitor. It is being evaluated for the treatment of patients with treatment-resistant depression.

                            Product Name : DB104

                            Product Type : Other Small Molecule

                            Upfront Cash : Inapplicable

                            September 10, 2024

                            Lead Product(s) : Liafensine

                            Therapeutic Area : Psychiatry/Psychology

                            Highest Development Status : Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            03

                            Denovo Biopharma

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                            ACS Fall 2025
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                            Denovo Biopharma

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                            ACS Fall 2025
                            Not Confirmed
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                            Lead Product(s) : Liafensine

                            Therapeutic Area : Psychiatry/Psychology

                            Study Phase : Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Denovo Biopharma Announces Breakthrough in Treatment-Resistant Depression

                            Details : DB104 (liafensine) is a first-in-class triple reuptake inhibitor targeting serotonin, norepinephrine, and dopamine transporters, being studied for treatment-resistant depression.

                            Product Name : DB104

                            Product Type : Other Small Molecule

                            Upfront Cash : Inapplicable

                            March 04, 2024

                            Lead Product(s) : Liafensine

                            Therapeutic Area : Psychiatry/Psychology

                            Highest Development Status : Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            04

                            Denovo Biopharma

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                            ACS Fall 2025
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                            Denovo Biopharma

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                            ACS Fall 2025
                            Not Confirmed
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                            Lead Product(s) : Liafensine

                            Therapeutic Area : Psychiatry/Psychology

                            Study Phase : Phase II

                            Sponsor : Curia

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            First Patient Dosed in the ENLIGHTEN Biomarker-Guided Global Clinical Trial of DB104 (Liafensine) for Treatmen...

                            Details : Denovo discovered a novel genetic biomarker for DB104 (liafensine) efficacy using its unique machine learning approach with whole genome sequencing to identify biomarkers that may be predictive of a patient's response to a specific medicine.

                            Product Name : DB104

                            Product Type : Other Small Molecule

                            Upfront Cash : Inapplicable

                            July 28, 2022

                            Lead Product(s) : Liafensine

                            Therapeutic Area : Psychiatry/Psychology

                            Highest Development Status : Phase II

                            Sponsor : Curia

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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