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    [{"orgOrder":0,"company":"Leap Therapeutics","sponsor":"Gilead Sciences","pharmaFlowCategory":"D","therapeuticArea":"Oncology","country":"U.S.A","productType":"Antibody","year":"2024","type":"Private Placement","leadProduct":"5 Fluorouracil","moa":"||DKK1","graph1":"Oncology","graph2":"Phase II","graph3":"Leap Therapeutics","amount2":0,"highestDevelopmentShortName":"Ph II","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Intravenous Infusion","sponsorNew":"Leap Therapeutics \/ Gilead Sciences","highestDevelopmentStatusID":"8","companyTruncated":"Leap Therapeutics \/ Gilead Sciences"},{"orgOrder":0,"company":"Leap Therapeutics","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"U.S.A","productType":"Antibody","year":"2025","type":"Inapplicable","leadProduct":"5 Fluorouracil","moa":"||DKK1","graph1":"Oncology","graph2":"Phase II","graph3":"Leap Therapeutics","amount2":0,"highestDevelopmentShortName":"Ph 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    Find Clinical Drug Pipeline Developments & Deals by Leap Therapeutics

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                            01

                            Leap Therapeutics

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                            Lead Product(s) : Sirexatamab,Fluorouracil,Irinotecan Hydrochloride

                            Therapeutic Area : Oncology

                            Study Phase : Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Leap Crashes as Midphase Data Mark End of Gastric Cancer Program

                            Details : DKN-01 (sirexatamab) a DKK1 inhibitor is being investigated in combination with bevacizumab and chemotherapy as a second-line treatment for patients with advanced colorectal cancer.

                            Product Name : DKN-01

                            Product Type : Antibody

                            Upfront Cash : Inapplicable

                            January 28, 2025

                            Lead Product(s) : Sirexatamab,Fluorouracil,Irinotecan Hydrochloride

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            02

                            Leap Therapeutics

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                            American Thoracic Society
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                            Leap Therapeutics

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                            Lead Product(s) : Sirexatamab,Fluorouracil,Irinotecan Hydrochloride

                            Therapeutic Area : Oncology

                            Study Phase : Phase II

                            Sponsor : Gilead Sciences

                            Deal Size : $40.0 million

                            Deal Type : Private Placement

                            DEALS_DEV arrow-down

                            Leap Therapeutics Announces $40 Million Private Placement

                            Details : Leap intends to use the net proceeds from the financing to fund the continued development of its lead monoclonal antibody program, DKN-01 for the treatment of Colorectal Cancer.

                            Product Name : DKN-01

                            Product Type : Antibody

                            Upfront Cash : Undisclosed

                            November 04, 2024

                            Lead Product(s) : Sirexatamab,Fluorouracil,Irinotecan Hydrochloride

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase II

                            Sponsor : Gilead Sciences

                            Deal Size : $40.0 million

                            Deal Type : Private Placement

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                            03

                            Leap Therapeutics

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                            Lead Product(s) : Sirexatamab,Bevacizumab,Irinotecan Hydrochloride

                            Therapeutic Area : Oncology

                            Study Phase : Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Leap Therapeutics Announces Initiation of Randomized Controlled Part B of the DeFianCe Study of DKN-01 in Colo...

                            Details : DKN-01, is an anti-Dickkopf-1 (DKK1) antibody and in combination with standard of care bevacizumab and chemotherapy as a second-line treatment for patients with advanced CRC.

                            Product Name : DKN-01

                            Product Type : Antibody

                            Upfront Cash : Inapplicable

                            December 07, 2023

                            Lead Product(s) : Sirexatamab,Bevacizumab,Irinotecan Hydrochloride

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            04

                            Leap Therapeutics

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                            Leap Therapeutics

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                            Lead Product(s) : Sirexatamab,Bevacizumab,Irinotecan Hydrochloride

                            Therapeutic Area : Oncology

                            Study Phase : Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Leap Therapeutics Announces Completion of Enrollment in Part A of the DeFianCe Study of DKN-01 for the Treatme...

                            Details : DKN-01 is a humanized monoclonal antibody that binds to and blocks the activity of the Dickkopf-1 (DKK1) protein. DKK1 has an important role in mediating an immune suppressive tumor microenvironment and in promoting tumor proliferation, metastasis, and a...

                            Product Name : DKN-01

                            Product Type : Antibody

                            Upfront Cash : Inapplicable

                            December 04, 2023

                            Lead Product(s) : Sirexatamab,Bevacizumab,Irinotecan Hydrochloride

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            05

                            Leap Therapeutics

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                            American Thoracic Society
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                            Leap Therapeutics

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                            Lead Product(s) : Sirexatamab,Bevacizumab,Irinotecan Hydrochloride

                            Therapeutic Area : Oncology

                            Study Phase : Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Leap Therapeutics Announces First Patient Enrolled in DeFianCe Study of DKN-01 for the Treatment of Colorectal...

                            Details : DKN-01 is a humanized monoclonal antibody that binds to and blocks the activity of the Dickkopf-1 (DKK1) protein. DKK1 modulates the Wnt/Beta-catenin and PI3kinase/AKT signaling pathways and has an important role in promoting tumor proliferation, metasta...

                            Product Name : DKN-01

                            Product Type : Antibody

                            Upfront Cash : Inapplicable

                            October 17, 2022

                            Lead Product(s) : Sirexatamab,Bevacizumab,Irinotecan Hydrochloride

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            06

                            Leap Therapeutics

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                            Lead Product(s) : Sirexatamab,Docetaxel

                            Therapeutic Area : Oncology

                            Study Phase : Phase I/ Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Leap Therapeutics to Present Initial Data from the Investigator-Sponsored Study of DKN-01 Plus Docetaxel in Pa...

                            Details : No DLTs were observed at DKN-01 300mg or 600mg dose levels as monotherapy or in combination with docetaxel, and no treatment-related adverse events occurred in either cohort.

                            Product Name : DKN-01

                            Product Type : Antibody

                            Upfront Cash : Inapplicable

                            May 26, 2022

                            Lead Product(s) : Sirexatamab,Docetaxel

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase I/ Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            07

                            Leap Therapeutics

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                            Lead Product(s) : Sirexatamab,Tislelizumab

                            Therapeutic Area : Oncology

                            Study Phase : Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Leap Therapeutics Stock Jumps 47% on Positive DKN-01 + Tislelizumab Data in Gastroesophageal Cancer

                            Details : DKN-01 plus tislelizumab and chemotherapy demonstrated compelling activity in first-line patients with gastric or gastroesophageal junction cancer. DKN-01, is a humanized monoclonal antibody targeting the Dickkopf-1 (DKK1) protein.

                            Product Name : DKN-01

                            Product Type : Antibody

                            Upfront Cash : Inapplicable

                            September 16, 2021

                            Lead Product(s) : Sirexatamab,Tislelizumab

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            08

                            Leap Therapeutics

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                            Lead Product(s) : Sirexatamab,Tislelizumab

                            Therapeutic Area : Oncology

                            Study Phase : Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Leap Therapeutics to Present at the ESMO 2021 Virtual Congress

                            Details : The DisTinGuish study is a Phase 2a, non-randomized, open-label, multicenter study of DKN-01 in combination with tislelizumab, as first-line or second-line therapy in adult patients with inoperable, locally advanced gastric or gastroesophageal junction c...

                            Product Name : DKN-01

                            Product Type : Antibody

                            Upfront Cash : Inapplicable

                            July 26, 2021

                            Lead Product(s) : Sirexatamab,Tislelizumab

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            09

                            Leap Therapeutics

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                            Lead Product(s) : Sirexatamab

                            Therapeutic Area : Oncology

                            Study Phase : Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Leap Therapeutics Presents DKN-01 Clinical Data at the Society of Gynecologic Oncology 2021 Annual Meeting on ...

                            Details : The P204 study was a Phase 2 basket study evaluating DKN-01 as a monotherapy or in combination with paclitaxel in groups composed of epithelial endometrial cancer (EEC), epithelial ovarian cancer (EOC), or carcinosarcoma (MMMT) patients.

                            Product Name : DKN-01

                            Product Type : Antibody

                            Upfront Cash : Inapplicable

                            March 22, 2021

                            Lead Product(s) : Sirexatamab

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            10

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                            Lead Product(s) : Sirexatamab,Tislelizumab

                            Therapeutic Area : Oncology

                            Study Phase : Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Leap Therapeutics Announces Completion of Enrollment for First-Line Patient Cohort in Study of DKN-01 in Combi...

                            Details : The DisTinGuish trial is a Phase 2a, nonrandomized, open-label, multicenter study of DKN-01 in combination with tislelizumab with or without chemotherapy as first-line or second-line therapy in adult patients with inoperable, locally advanced G/GEJ adeno...

                            Product Name : DKN-01

                            Product Type : Antibody

                            Upfront Cash : Inapplicable

                            January 04, 2021

                            Lead Product(s) : Sirexatamab,Tislelizumab

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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