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                          Top Deals by Deal Size (USD bn)

                          01

                          AAPS National Biotech
                          Not Confirmed
                          AAPS National Biotech
                          Not Confirmed

                          Details : The proceeds from the financing will be used to advance the IAM1363, a highly selective, brain-penetrant small molecule inhibitor, being evaluated for the treatment of HER2-mutated neoplasms.

                          Product Name : IAM1363

                          Product Type : Other Small Molecule

                          Upfront Cash : Undisclosed

                          June 18, 2024

                          Lead Product(s) : IAM1363,Trastuzumab

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I

                          Sponsor : Mubadala Capital

                          Deal Size : $150.0 million

                          Deal Type : Series B Financing

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                          02

                          AAPS National Biotech
                          Not Confirmed
                          AAPS National Biotech
                          Not Confirmed

                          Details : IAM1363 inhibits both wild type and mutant HER2 forms, showing over 1000-fold selectivity against EGFR, being evaluated for HER2-driven cancers.

                          Product Name : IAM1363

                          Product Type : Other Small Molecule

                          Upfront Cash : Inapplicable

                          March 28, 2024

                          Lead Product(s) : IAM1363

                          Therapeutic Area : Oncology

                          Highest Development Status : Preclinical

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          03

                          AAPS National Biotech
                          Not Confirmed
                          AAPS National Biotech
                          Not Confirmed

                          Details : The financing will advance multiple candidates into clinical development, expand its pipeline with best-in-class and first-in-class potential, including IAM-H1, a Selective Brain-Penetrant HER2 Inhibitor, and IAM-C1, a Selective Dual CDK2/4 Inhibitor.

                          Product Name : IAM-H1

                          Product Type : Other Small Molecule

                          Upfront Cash : Undisclosed

                          March 10, 2023

                          Lead Product(s) : IAM-H1

                          Therapeutic Area : Oncology

                          Highest Development Status : IND Enabling

                          Sponsor : Ascenta Capital

                          Deal Size : $100.0 million

                          Deal Type : Series B Financing

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