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    [{"orgOrder":0,"company":"Kala Pharmaceuticals","sponsor":"Kala Pharmaceuticals","pharmaFlowCategory":"DU","therapeuticArea":"Ophthalmology","country":"U.S.A","productType":"Steroid","year":"2021","type":"Inapplicable","leadProduct":"Loteprednol Etabonate","moa":"Glucocorticoid receptor","graph1":"Ophthalmology","graph2":"Phase IV","graph3":"Kala Pharmaceuticals","amount2":0,"highestDevelopmentShortName":"Ph IV","therapeuticAreaShortName":"Ophthalmology","amount2New":0,"dosageForm":"Suspension","sponsorNew":"Kala Pharmaceuticals \/ Kala Pharmaceuticals","highestDevelopmentStatusID":"11","companyTruncated":"Kala Pharmaceuticals \/ Kala Pharmaceuticals"},{"orgOrder":0,"company":"Kala Pharmaceuticals","sponsor":"Oxford Finance","pharmaFlowCategory":"D","therapeuticArea":"Ophthalmology","country":"U.S.A","productType":"Steroid","year":"2021","type":"Financing","leadProduct":"Loteprednol Etabonate","moa":"Glucocorticoid receptor","graph1":"Ophthalmology","graph2":"Approved 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                            01

                            Kala Pharmaceuticals

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                            Lead Product(s) : KPI-012

                            Therapeutic Area : Ophthalmology

                            Study Phase : Phase II

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Kala Pharmaceuticals Receives FDA Fast Track Designation for KPI-012, a Human MSC-S Therapy for Persistent Cor...

                            Details : KPI-012 is a human MSC-S, which contains numerous human-derived biofactors, such as growth factors, protease inhibitors, matrix proteins and neurotrophic factors that can potentially treat persistent corneal epithelial defect (PCED).

                            Product Name : Undisclosed

                            Product Type : Protein

                            Upfront Cash : Inapplicable

                            April 12, 2023

                            Lead Product(s) : KPI-012

                            Therapeutic Area : Ophthalmology

                            Highest Development Status : Phase II

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            02

                            Kala Pharmaceuticals

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                            The MedTech Conference
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                            Kala Pharmaceuticals

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                            The MedTech Conference
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                            Lead Product(s) : KPI-012

                            Therapeutic Area : Ophthalmology

                            Study Phase : Phase II

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Kala Pharmaceuticals Announces Positive Safety Update from Cohort 1 of CHASE Phase 2b Clinical Trial Evaluatin...

                            Details : KPI-012 is a human MSC-S, which contains numerous human-derived biofactors, such as growth factors, protease inhibitors, matrix proteins and neurotrophic factors that can potentially treat persistent corneal epithelial defect (PCED).

                            Product Name : Undisclosed

                            Product Type : Protein

                            Upfront Cash : Inapplicable

                            March 27, 2023

                            Lead Product(s) : KPI-012

                            Therapeutic Area : Ophthalmology

                            Highest Development Status : Phase II

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            03

                            Kala Pharmaceuticals

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                            The MedTech Conference
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                            Lead Product(s) : KPI-012

                            Therapeutic Area : Ophthalmology

                            Study Phase : Phase II

                            Sponsor : Kala Pharmaceuticals

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Trial to Evaluate Safety and Efficacy of KPI-012 Ophthalmic Solution in Participants With PCED

                            Details : KPI-012 is a Protein drug candidate, which is currently being evaluated in phase II clinical studies for the treatment of Corneal Diseases.

                            Product Name : Undisclosed

                            Product Type : Protein

                            Upfront Cash : Inapplicable

                            February 14, 2023

                            Lead Product(s) : KPI-012

                            Therapeutic Area : Ophthalmology

                            Highest Development Status : Phase II

                            Sponsor : Kala Pharmaceuticals

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            04

                            Kala Pharmaceuticals

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                            The MedTech Conference
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                            Kala Pharmaceuticals

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                            Lead Product(s) : KPI-012

                            Therapeutic Area : Ophthalmology

                            Study Phase : Phase I

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Kala Pharmaceuticals Announces FDA Acceptance of IND Application for KPI-012 for the Treatment of PCED

                            Details : KPI-012, is a human MSC-S, which contains numerous human-derived biofactors, it has the potential to correct the impaired corneal healing that is an underlying etiology of multiple severe ocular diseases.

                            Product Name : Undisclosed

                            Product Type : Protein

                            Upfront Cash : Inapplicable

                            December 27, 2022

                            Lead Product(s) : KPI-012

                            Therapeutic Area : Ophthalmology

                            Highest Development Status : Phase I

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            05

                            Kala Pharmaceuticals

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                            The MedTech Conference
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                            Kala Pharmaceuticals

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                            Lead Product(s) : KPI-012

                            Therapeutic Area : Ophthalmology

                            Study Phase : Phase I

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Kala Pharmaceuticals Announces Submission of Investigational New Drug Application for KPI-012 for the Treatmen...

                            Details : KPI-012, is human MSC-S, which contains numerous human-derived biofactors, such as growth factors, protease inhibitors, matrix proteins and neurotrophic factors can potentially correct impaired corneal healing that is an underlying etiology of multiple s...

                            Product Name : Undisclosed

                            Product Type : Protein

                            Upfront Cash : Inapplicable

                            November 28, 2022

                            Lead Product(s) : KPI-012

                            Therapeutic Area : Ophthalmology

                            Highest Development Status : Phase I

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            06

                            Kala Pharmaceuticals

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                            Lead Product(s) : KPI-012

                            Therapeutic Area : Ophthalmology

                            Study Phase : Phase I

                            Sponsor : Undisclosed

                            Deal Size : $31.0 million

                            Deal Type : Private Placement

                            DEALS_DEV arrow-down

                            Kala Pharmaceuticals Announces Up to $31 Million Private Placement Financing

                            Details : Kala intends to use proceeds from the financing to advance the clinical development of KPI-012 for the treatment of PCED, as well as for general corporate purposes.

                            Product Name : Undisclosed

                            Product Type : Protein

                            Upfront Cash : Undisclosed

                            November 28, 2022

                            Lead Product(s) : KPI-012

                            Therapeutic Area : Ophthalmology

                            Highest Development Status : Phase I

                            Sponsor : Undisclosed

                            Deal Size : $31.0 million

                            Deal Type : Private Placement

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                            07

                            Kala Pharmaceuticals

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                            The MedTech Conference
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                            Kala Pharmaceuticals

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                            Lead Product(s) : Loteprednol Etabonate

                            Therapeutic Area : Ophthalmology

                            Study Phase : Approved FDF

                            Sponsor : Alcon Inc

                            Deal Size : Undisclosed

                            Deal Type : Acquisition

                            DEALS_DEV arrow-down

                            Alcon to Acquire EYSUVIS Adding to Its Ophthalmic Eye Drop Portfolio

                            Details : The acquisition will complement Alcon’s existing portfolio in the large and fast-growing dry eye category. EYSUVIS (Loteprednol Etabonate) will complement the Systane® family of eye drops which includes the recently launched Systane Preservative-Free ...

                            Product Name : Eysuvis

                            Product Type : Steroid

                            Upfront Cash : $60.0 million

                            May 23, 2022

                            Lead Product(s) : Loteprednol Etabonate

                            Therapeutic Area : Ophthalmology

                            Highest Development Status : Approved FDF

                            Sponsor : Alcon Inc

                            Deal Size : Undisclosed

                            Deal Type : Acquisition

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                            08

                            Kala Pharmaceuticals

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                            The MedTech Conference
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                            Kala Pharmaceuticals

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                            Lead Product(s) : KPI-012

                            Therapeutic Area : Ophthalmology

                            Study Phase : Phase I

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Kala Pharmaceuticals to Present Clinical Data for KPI-012, its Mesenchymal Stem Cell Secretome Product, for th...

                            Details : Data for CMB-012 (KPI-012), demonstrated rapid and complete wound healing, with six of eight (75%) patients achieving complete healing within four weeks; all remained healed through end of follow-up.

                            Product Name : Undisclosed

                            Product Type : Protein

                            Upfront Cash : Inapplicable

                            May 01, 2022

                            Lead Product(s) : KPI-012

                            Therapeutic Area : Ophthalmology

                            Highest Development Status : Phase I

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            09

                            Kala Pharmaceuticals

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                            The MedTech Conference
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                            Kala Pharmaceuticals

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                            Lead Product(s) : KPI-012

                            Therapeutic Area : Ophthalmology

                            Study Phase : Phase I

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Kala Pharmaceuticals to Present Phase 1b Clinical Data for KPI-012 in Patients with PCED at 2022 ARVO Annual M...

                            Details : KPI-012, a novel investigational secretome therapy, initially targeting persistent corneal epithelial defects and multiple proprietary new chemical entity preclinical development programs targeted to address unmet medical needs, including both front and ...

                            Product Name : Undisclosed

                            Product Type : Protein

                            Upfront Cash : Inapplicable

                            April 04, 2022

                            Lead Product(s) : KPI-012

                            Therapeutic Area : Ophthalmology

                            Highest Development Status : Phase I

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            10

                            Kala Pharmaceuticals

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                            Lead Product(s) : Loteprednol Etabonate

                            Therapeutic Area : Ophthalmology

                            Study Phase : Phase IV

                            Recipient : Price Vision Group

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Loteprednol Etabonate 0.25% for Prevention of Cornea Transplant Rejection

                            Details : Loteprednol Etabonate is a Steroid drug candidate, which is currently being evaluated in phase IV clinical studies for the treatment of Corneal Endothelial Dystrophy.

                            Product Name : Undisclosed

                            Product Type : Steroid

                            Upfront Cash : Inapplicable

                            November 29, 2021

                            Lead Product(s) : Loteprednol Etabonate

                            Therapeutic Area : Ophthalmology

                            Highest Development Status : Phase IV

                            Recipient : Price Vision Group

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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