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                          Top Deals by Deal Size (USD bn)

                          01

                          STLE Annual Meeting
                          Not Confirmed
                          STLE Annual Meeting
                          Not Confirmed

                          Details : JUV-161 is a muscle regenerating endocrine therapy being investigated for the treatment of Myotonic Dystrophy Type 1 (DM1) and Sarcopenia

                          Product Name : JUV-161

                          Product Type : Protein

                          Upfront Cash : Inapplicable

                          May 19, 2025

                          Lead Product(s) : JUV-161

                          Therapeutic Area : Genetic Disease

                          Highest Development Status : Phase I

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          02

                          STLE Annual Meeting
                          Not Confirmed
                          STLE Annual Meeting
                          Not Confirmed

                          Details : JUV-161, identified via Juvena’s AI platform, restores muscle fiber formation, counters muscle atrophy, and enhances strength, currently in preclinical studies for DM1.

                          Product Name : JUV-161

                          Product Type : Protein

                          Upfront Cash : Inapplicable

                          January 23, 2024

                          Lead Product(s) : JUV-161

                          Therapeutic Area : Neurology

                          Highest Development Status : IND Enabling

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          03

                          STLE Annual Meeting
                          Not Confirmed
                          STLE Annual Meeting
                          Not Confirmed

                          Details : JUV-161 is the only protein-based therapeutic being developed for a rare muscle-wasting disease, myotonic dystrophy type 1 (DM1).

                          Product Name : JUV-161

                          Product Type : Protein

                          Upfront Cash : Undisclosed

                          August 11, 2022

                          Lead Product(s) : JUV-161

                          Therapeutic Area : Neurology

                          Highest Development Status : IND Enabling

                          Sponsor : Mubadala Capital

                          Deal Size : $41.0 million

                          Deal Type : Series A Financing

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                          04

                          STLE Annual Meeting
                          Not Confirmed
                          STLE Annual Meeting
                          Not Confirmed

                          Details : The grant will fund the advancement of Juvena's lead program, fusion protein therapeutic JUV-161, for the treatment of the rare muscle-wasting disease, DM1, through initial IND-enabling studies and a pre-IND FDA meeting in the next 12-16 months.

                          Product Name : JUV-161

                          Product Type : Protein

                          Upfront Cash : Undisclosed

                          February 02, 2022

                          Lead Product(s) : JUV-161

                          Therapeutic Area : Neurology

                          Highest Development Status : Preclinical

                          Sponsor : California Institute for Regenerative Medicine

                          Deal Size : $3.9 million

                          Deal Type : Funding

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