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    [{"orgOrder":0,"company":"Ivy Brain Tumor Center","sponsor":"GSK","pharmaFlowCategory":"D","amount":"Undisclosed","upfrontCash":"Undisclosed","newsHeadline":"Ivy Brain Tumor Center Collaborates with GSK on New Phase 0 Clinical Trial to Evaluate Niraparib in Patients with Brain Cancer","therapeuticArea":"Oncology","highestDevelopmentStatus":"IND Enabling","country":"U.S.A","productType":"Small molecule","productStatus":"Approved","date":"October 2021","url1":"","url2":"","graph1":"Oncology","graph2":"IND Enabling"},{"orgOrder":0,"company":"Ivy Brain Tumor Center","sponsor":"BeiGene","pharmaFlowCategory":"DU","amount":"Not Applicable","upfrontCash":"Not Applicable","newsHeadline":"Ivy Brain Tumor Center Announces Initial Results of Pamiparib in Newly-Diagnosed and Recurrent Glioblastoma at the European Society for Medical Oncology (ESMO) 2022 Congress","therapeuticArea":"Oncology","highestDevelopmentStatus":"Phase I\/ Phase II","country":"U.S.A","productType":"Small molecule","productStatus":"Approved","date":"September 2022","url1":"","url2":"","graph1":"Oncology","graph2":"Phase I\/ Phase II"}]

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              Ivy Brain Tumor Center

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              Ivy Brain Tumor Center Announces Initial Results of Pamiparib in Newly-Diagnosed and Recurrent Glioblastoma at the European Society for Medical Oncology (ESMO) 2022 Congres...

              Details:

              The interim analysis demonstrated that pamiparib is well-tolerated in glioblastoma patients, reaches pharmacologically-relevant concentrations in nonenhancing GBM tissue, and sensitizes brain tumor tissue to radiation ex vivo.

              Lead Product(s): Pamiparib,Temozolomide

              Therapeutic Area: Oncology Product Name: BGB-290

              Highest Development Status: Phase I/ Phase II Product Type: Small molecule

              Recipient: BeiGene

              Deal Size: Not Applicable Upfront Cash: Not Applicable

              Deal Type: Not Applicable September 10, 2022

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              Ivy Brain Tumor Center

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              Ivy Brain Tumor Center Collaborates with GSK on New Phase 0 Clinical Trial to Evaluate Niraparib in Patients with Brain Cancer

              Details:

              The launch of the Phase 0 clinical trial with niraparib will begin by enrolling six Arm A participants to determine the Optimal Time Interval (OTI) and the tumor resection that can detect maximum unbound drug concentration in the gadolinium nonenhancing region of the tumor.

              Lead Product(s): Niraparib Tosylate

              Therapeutic Area: Oncology Product Name: Zejula

              Highest Development Status: IND Enabling Product Type: Small molecule

              Partner/Sponsor/Collaborator: GSK

              Deal Size: Undisclosed Upfront Cash: Undisclosed

              Deal Type: Collaboration October 22, 2021

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              Biopharma Group offers CDMO services with expertise in contract R&D for dried products & liquid formulations.
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