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Find Clinical Drug Development Pipelines & Deals | PipelineProspector

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                          01

                          OTS 2025
                          Not Confirmed
                          OTS 2025
                          Not Confirmed

                          Details : RHB-107 (upamostat) is a proprietary, first-in-class, once-daily orally administered investigational antiviral, that targets human serine proteases involved in preparing the spike protein for viral entry into target cells.

                          Product Name : Undisclosed

                          Product Type : Miscellaneous

                          Upfront Cash : Inapplicable

                          July 31, 2023

                          Lead Product(s) : Upamostat

                          Therapeutic Area : Infections and Infectious Diseases

                          Highest Development Status : Phase II/ Phase III

                          Sponsor : Undisclosed

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          02

                          OTS 2025
                          Not Confirmed
                          OTS 2025
                          Not Confirmed

                          Details : RHB-107 (Upamostat) is a proprietary, first-in-class, once-daily orally administered investigational antiviral, that targets human serine proteases involved in preparing the spike protein for viral entry into target cells.

                          Product Name : Undisclosed

                          Product Type : Miscellaneous

                          Upfront Cash : Inapplicable

                          January 03, 2023

                          Lead Product(s) : Upamostat

                          Therapeutic Area : Infections and Infectious Diseases

                          Highest Development Status : Phase II/ Phase III

                          Sponsor : Undisclosed

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          03

                          OTS 2025
                          Not Confirmed
                          OTS 2025
                          Not Confirmed

                          Details : USPTO grants new method of use patent for the inhibition of a disease caused by a coronavirus in patients having pneumonia and receiving supplemental oxygen at a fraction of inspired oxygen (FiO2) up to and including 60%.

                          Product Name : Yeliva

                          Product Type : Miscellaneous

                          Upfront Cash : Inapplicable

                          October 19, 2022

                          Lead Product(s) : Opaganib

                          Therapeutic Area : Infections and Infectious Diseases

                          Highest Development Status : Phase II/ Phase III

                          Sponsor : Undisclosed

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

                          blank

                          04

                          OTS 2025
                          Not Confirmed
                          OTS 2025
                          Not Confirmed

                          Details : Yeliva (opaganib (ABC294640), a new chemical entity, is a proprietary, rst-in-class, orally-administered, investigational sphingosine kinase-2 (SK2) selective inhibitor, with suggested dual anti-inammatory and antiviral activity.

                          Product Name : Yeliva

                          Product Type : Miscellaneous

                          Upfront Cash : Inapplicable

                          July 12, 2022

                          Lead Product(s) : Opaganib

                          Therapeutic Area : Infections and Infectious Diseases

                          Highest Development Status : Phase II/ Phase III

                          Sponsor : Undisclosed

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          05

                          OTS 2025
                          Not Confirmed
                          OTS 2025
                          Not Confirmed

                          Details : The partnership with Kukbo also includes a right of first offer for RedHill's late-stage clinical assets, opaganib, RHB-107 (upamostat) and Talicia®, for one or more of the territories of South Korea, Japan, Indonesia, Vietnam, Thailand and/or Malaysia.

                          Product Name : Yeliva

                          Product Type : Miscellaneous

                          Upfront Cash : $1.5 million

                          March 15, 2022

                          Lead Product(s) : Opaganib

                          Therapeutic Area : Infections and Infectious Diseases

                          Highest Development Status : Phase II/ Phase III

                          Sponsor : Kukbo Co

                          Deal Size : $7.1 million

                          Deal Type : Licensing Agreement

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                          06

                          OTS 2025
                          Not Confirmed
                          OTS 2025
                          Not Confirmed

                          Details : Phase 2 part of Phase 2/3 study of RHB-107 (upamostat), orally-administered antiviral, that targets human serine proteases in symptomatic COVID-19 successfully met study's primary endpoint showing good safety, tolerability and highly promising efficacy r...

                          Product Name : Undisclosed

                          Product Type : Miscellaneous

                          Upfront Cash : Inapplicable

                          March 01, 2022

                          Lead Product(s) : Upamostat

                          Therapeutic Area : Infections and Infectious Diseases

                          Highest Development Status : Phase II/ Phase III

                          Sponsor : Undisclosed

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          07

                          OTS 2025
                          Not Confirmed
                          OTS 2025
                          Not Confirmed

                          Details : In a prespecified analysis of Phase 2/3 study patients with positive PCR at screening, Yeliva (opaganib) improved the median time to viral RNA clearance by at least 4 days also showed 62% reduction in mortality seen in a post-hoc analysis.

                          Product Name : Yeliva

                          Product Type : Miscellaneous

                          Upfront Cash : Inapplicable

                          January 13, 2022

                          Lead Product(s) : Opaganib

                          Therapeutic Area : Infections and Infectious Diseases

                          Highest Development Status : Phase II/ Phase III

                          Sponsor : Undisclosed

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          08

                          OTS 2025
                          Not Confirmed
                          OTS 2025
                          Not Confirmed

                          Details : Under the terms of agreement, RedHill has agreed to grant Kukbo a right of first offer, for a period of six months, for a license of late-stage clinical assets, opaganib, RHB-107 (upamostat)1 and Talicia®, for one or more of the territories.

                          Product Name : Yeliva

                          Product Type : Miscellaneous

                          Upfront Cash : Undisclosed

                          November 08, 2021

                          Lead Product(s) : Opaganib

                          Therapeutic Area : Infections and Infectious Diseases

                          Highest Development Status : Phase II/ Phase III

                          Sponsor : Kukbo Co

                          Deal Size : $10.0 million

                          Deal Type : Private Placement

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                          09

                          OTS 2025
                          Not Confirmed
                          OTS 2025
                          Not Confirmed

                          Details : Opaganib, a new chemical entity, is a proprietary, first-in-class, orally-administered, sphingosine kinase-2 (SK2) selective inhibitor, with dual anti-inflammatory and antiviral activity that acts on the viral cause and inflammatory effect of COVID-19.

                          Product Name : Yeliva

                          Product Type : Miscellaneous

                          Upfront Cash : Inapplicable

                          October 04, 2021

                          Lead Product(s) : Opaganib

                          Therapeutic Area : Infections and Infectious Diseases

                          Highest Development Status : Phase II/ Phase III

                          Sponsor : Undisclosed

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          10

                          OTS 2025
                          Not Confirmed
                          OTS 2025
                          Not Confirmed

                          Details : While preliminary top-line data of the study efficacy endpoints showed consistent trends in favor of the opaganib arm, the study endpoints did not achieve statistical significance.

                          Product Name : Yeliva

                          Product Type : Miscellaneous

                          Upfront Cash : Inapplicable

                          September 14, 2021

                          Lead Product(s) : Opaganib

                          Therapeutic Area : Infections and Infectious Diseases

                          Highest Development Status : Phase II/ Phase III

                          Sponsor : Undisclosed

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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