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CoronaTcP (PepGNP-COVID19 Vaccine) designed to be broadly effective against disease caused by Betacoronaviruses, including SARS-CoV-1, as well as known and emerging variants of SARS-CoV-2.
NgG (Neisseria gonorrhoeae vaccine) candidate is currently in an ongoing Phase II trial and aims to demonstrate proof of concept by assessing the efficacy of the NgG vaccine in healthy adults, 18 to 50 years of age, considered at risk of gonorrhoea.
GSK4382276A is a mRNA seasonal flu vaccine which activates immunization for the prevention of disease caused by influenza viruses in adults 18 years and above.
VTP-200 is an investigational heterologous prime boost immunotherapy consisting of an initial dose using the ChAdOx vector and a second dose using MVA, both encoding the same HPV antigens, to elicit an immune response to HPV.
AZD5156 is an investigational, long-acting antibody combination of cilgavimab, a component of EVUSHELD (tixagevimab and cilgavimab, formerly AZD7442), and a new long-acting monoclonal antibody (mAb), AZD3152.
In the initial cohort, HBsAg declines and ALT elevations indicated that a single, very low dose of IMC-I109V elicited on-target activity, consistent with mechanism of action and without any adverse events.
Data from an interim analysis of MVA-HBV (VTP-300), demonstrated noted changes in surface antigen level in CHB patients, results support a protocol change that will lead to a focus on enrolling patients into Groups 2 and 3.
VTP-300 is an immunotherapeutic agent that Vaccitech intends to administer in combination with a low-dose anti-PD-1 antibody, to counterbalance the immune suppression and T cell exhaustion in the liver caused by CHB.
Modus is currently developing sevuparin in sepsis/septic shock, and other conditions with systemic inflammation, with severe malaria being a further example. These conditions constitute major healthcare problems.
The proceeds from the financing will support the continued development of three infectious disease and immuno-oncology programs including A Phase 1/2 clinical trial of VTP-300 in patients with chronic hepatitis B virus (HBV) infection.