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As part of the collaboration, Curia’s experienced process development team will support the GMP production of Replicate Bioscience’s srRNA vectors up to eight-liter scale (8L), which can be used in Phase 1 through pivotal clinical trials.
Eight animals showed detectable drug levels of a variant of Adalimumab (PGN-OB1) with an oral bioavailability average of 25% (range from 7-55%), excluding one animal with a late deployment at 72 hours post-dose.
As with batoclimab, (IMVT-1402), potentially best-in-class IgG reduction formulated for same simple subcutaneous route of administration delivered in matter of seconds. IMVT1402 has been observed to have minimal or no impact on levels of albumin and LDL in animal studies.
The company intends to use the net proceeds for general corporate purposes, which may include research and development expenses for plasmid DNA-based therapeutics, capital expenditures, working capital and general and administrative expenses.
The data involve studies of Tonix’s TNX-1500 (Fc modified anti-CD40L monoclonal antibody) product candidate in development for the prevention of organ transplant rejection. The molecular target of TNX-1500 is CD40-ligand (CD40L), which is also known as CD154.
CUE-401, a novel bispecific molecule designed for differentiation and expansion of induced regulatory T cells (iTregs),or the treatment of patients with autoimmune and graft-versus-host disease.
TNX-1500 is mAb directed against CD40-ligand, which is known as CD154, T-BAM, 5c8 antigen, TRAP and gp39. TNX-1500 incorporates Fab region of hu5c8, that has been extensively characterized at molecular level in complex with CD40-ligand.
TRE-515, Trethera’s first-in-class drug for the treatment of acute disseminated encephalomyelitis (ADEM). ADEM is a rare autoimmune disease where patients lose their nerve function and become paralyzed, causing death in some cases.
ADI-100 consists of two DNA molecules, which together restore immune tolerance in autoimmune disease and establish tolerance in allogeneic skin transplantation applied in large skin wounds.
Enosi's Growth Factor Trap (EN-2000 Program) and TNFR1 Blocker (EN1001) were licensed as part of the partnership. Both programs have the potential to be used as cross-over drugs to treat cancer and autoimmune diseases.
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