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Pharmaceuticals","sponsor":"Genentech","pharmaFlowCategory":"D","therapeuticArea":"Immunology","country":"U.S.A","productType":"Undisclosed","year":"2024","type":"Collaboration","leadProduct":"Tolerogenic Nanoparticle","moa":"Undisclosed","graph1":"Immunology","graph2":"Preclinical","graph3":"Cour Pharmaceuticals","amount2":0.93999999999999995,"highestDevelopmentShortName":"Preclinical","therapeuticAreaShortName":"Immunology","amount2New":0.93999999999999995,"dosageForm":"Undisclosed","sponsorNew":"Cour Pharmaceuticals \/ Genentech","highestDevelopmentStatusID":"4","companyTruncated":"Cour Pharmaceuticals \/ Genentech"},{"orgOrder":0,"company":"CEL-SCI","sponsor":"National Institutes of Health","pharmaFlowCategory":"DU","therapeuticArea":"Immunology","country":"U.S.A","productType":"Vaccine","year":"2020","type":"Inapplicable","leadProduct":"CEL-4000","moa":"IL-17-alpha receptor","graph1":"Immunology","graph2":"Preclinical","graph3":"CEL-SCI","amount2":0,"highestDevelopmentShortName":"Preclinical","therapeuticAreaShortName":"Immunology","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"CEL-SCI \/ National Institutes of Health","highestDevelopmentStatusID":"4","companyTruncated":"CEL-SCI \/ National Institutes of Health"},{"orgOrder":0,"company":"AGC Biologics","sponsor":"Quell Therapeutics","pharmaFlowCategory":"D","therapeuticArea":"Immunology","country":"U.S.A","productType":"Undisclosed","year":"2025","type":"Collaboration","leadProduct":"Undisclosed","moa":"Undisclosed","graph1":"Immunology","graph2":"Preclinical","graph3":"AGC Biologics","amount2":0,"highestDevelopmentShortName":"Preclinical","therapeuticAreaShortName":"Immunology","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"AGC Biologics \/ Quell Therapeutics","highestDevelopmentStatusID":"4","companyTruncated":"AGC Biologics \/ Quell Therapeutics"},{"orgOrder":0,"company":"ExesaLibero Pharma","sponsor":"SpaceMD","pharmaFlowCategory":"D","therapeuticArea":"Immunology","country":"U.S.A","productType":"Other Small Molecule","year":"2025","type":"Agreement","leadProduct":"N-(3,4-Dichlorophenyl)-N-methylpropanamide","moa":"CYP1A2\/CYP2B6","graph1":"Immunology","graph2":"Preclinical","graph3":"ExesaLibero Pharma","amount2":0,"highestDevelopmentShortName":"Preclinical","therapeuticAreaShortName":"Immunology","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"ExesaLibero Pharma \/ SpaceMD","highestDevelopmentStatusID":"4","companyTruncated":"ExesaLibero Pharma \/ SpaceMD"},{"orgOrder":0,"company":"Curanex Pharmaceuticals","sponsor":"Dominari Securities","pharmaFlowCategory":"D","therapeuticArea":"Immunology","country":"U.S.A","productType":"Plant Extract\/Herbal","year":"2025","type":"Public Offering","leadProduct":"Phyto-N","moa":"Undisclosed","graph1":"Immunology","graph2":"Preclinical","graph3":"Curanex Pharmaceuticals","amount2":0.02,"highestDevelopmentShortName":"Preclinical","therapeuticAreaShortName":"Immunology","amount2New":0.02,"dosageForm":"Undisclosed","sponsorNew":"Curanex Pharmaceuticals \/ Dominari Securities","highestDevelopmentStatusID":"4","companyTruncated":"Curanex Pharmaceuticals \/ Dominari Securities"}]

    Find Clinical Drug Development Pipelines & Deals | PipelineProspector

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                            01

                            Curanex Pharmaceuticals

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                            Curanex Pharmaceuticals

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                            Lead Product(s) : Phyto-N

                            Therapeutic Area : Immunology

                            Study Phase : Preclinical

                            Sponsor : Dominari Securities

                            Deal Size : $15.0 million

                            Deal Type : Public Offering

                            DEALS_DEV arrow-down

                            Curanex Pharmaceuticals Inc. Announces Pricing of its Initial Public Offering

                            Details : The Company intends to use the proceeds from the Offering for the development of its lead product candidate, Phyto-N, for the treatment of ulcerative colitis.

                            Product Name : Phyto-N

                            Product Type : Plant Extract/Herbal

                            Upfront Cash : Undisclosed

                            August 26, 2025

                            Lead Product(s) : Phyto-N

                            Therapeutic Area : Immunology

                            Highest Development Status : Preclinical

                            Sponsor : Dominari Securities

                            Deal Size : $15.0 million

                            Deal Type : Public Offering

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                            02

                            Trethera

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                            Trethera

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                            Lead Product(s) : TRE-515

                            Therapeutic Area : Immunology

                            Study Phase : Preclinical

                            Sponsor : National Institutes of Health

                            Deal Size : $3.0 million

                            Deal Type : Funding

                            DEALS_DEV arrow-down

                            Trethera Awarded $3 Million NIH Grant to Advance TRE-515 for the Treatment of Lupus

                            Details : Trethera will leverage the funding to complete advanced studies of TRE-515, including toxicology, pharmacology, and efficacy testing, with the goal of initiating trials in lupus patients.

                            Product Name : TRE-515

                            Product Type : Other Small Molecule

                            Upfront Cash : Undisclosed

                            August 19, 2025

                            Lead Product(s) : TRE-515

                            Therapeutic Area : Immunology

                            Highest Development Status : Preclinical

                            Sponsor : National Institutes of Health

                            Deal Size : $3.0 million

                            Deal Type : Funding

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                            03

                            ExesaLibero Pharma

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                            Not Confirmed

                            ExesaLibero Pharma

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                            Lead Product(s) : N-(3,4-Dichlorophenyl)-N-methylpropanamide

                            Therapeutic Area : Immunology

                            Study Phase : Preclinical

                            Sponsor : SpaceMD

                            Deal Size : Undisclosed

                            Deal Type : Agreement

                            DEALS_DEV arrow-down

                            SpaceMD Signs Trailblazing Royalty Agreement with ExesaLibero Pharma

                            Details : ExesaLibero Pharma will work with SpaceMD to advance and enhance its groundbreaking small-molecule drug ELP-004 and other relevant compounds via the PIL-BOX system.

                            Product Name : ELP-004

                            Product Type : Other Small Molecule

                            Upfront Cash : Undisclosed

                            August 04, 2025

                            Lead Product(s) : N-(3,4-Dichlorophenyl)-N-methylpropanamide

                            Therapeutic Area : Immunology

                            Highest Development Status : Preclinical

                            Sponsor : SpaceMD

                            Deal Size : Undisclosed

                            Deal Type : Agreement

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                            04

                            GeneFab

                            U.S.A arrow
                            ESCRS
                            Not Confirmed

                            GeneFab

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                            ESCRS
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                            Lead Product(s) : Undisclosed

                            Therapeutic Area : Immunology

                            Study Phase : Preclinical

                            Sponsor : RegCell

                            Deal Size : Undisclosed

                            Deal Type : Partnership

                            DEALS_DEV arrow-down

                            GeneFab & RegCell Partner for Treg Therapy Manufacturing in the U.S.

                            Details : The partnership will support the tech transfer and clinical manufacturing of RegCell’s Treg platform and accelerate U.S. clinical trials for autoimmune indications, including autoimmune hepatitis.

                            Product Name : Undisclosed

                            Product Type : Undisclosed

                            Upfront Cash : Undisclosed

                            May 07, 2025

                            Lead Product(s) : Undisclosed

                            Therapeutic Area : Immunology

                            Highest Development Status : Preclinical

                            Sponsor : RegCell

                            Deal Size : Undisclosed

                            Deal Type : Partnership

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                            05

                            AGC Biologics

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                            ESCRS
                            Not Confirmed

                            AGC Biologics

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                            ESCRS
                            Not Confirmed
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                            Lead Product(s) : Undisclosed

                            Therapeutic Area : Immunology

                            Study Phase : Preclinical

                            Sponsor : Novelty Nobility

                            Deal Size : Undisclosed

                            Deal Type : Partnership

                            DEALS_DEV arrow-down

                            AGC Biologics Teams With Novelty Nobility for Antibody Drug Phase I Prep

                            Details : Novelty Nobility will leverage AGC Biologics’ expertise and proprietary CHEF1® expression technology for cell line development and prepare for Phase I clinical trials

                            Product Name : Undisclosed

                            Product Type : Undisclosed

                            Upfront Cash : Undisclosed

                            May 05, 2025

                            Lead Product(s) : Undisclosed

                            Therapeutic Area : Immunology

                            Highest Development Status : Preclinical

                            Sponsor : Novelty Nobility

                            Deal Size : Undisclosed

                            Deal Type : Partnership

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                            06

                            Coya Therapeutics

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                            ESCRS
                            Not Confirmed

                            Coya Therapeutics

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                            Lead Product(s) : COYA 301,Undisclosed

                            Therapeutic Area : Immunology

                            Study Phase : Preclinical

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Coya Publishes COYA 303 Data Showing Treg Protection And Synergy

                            Details : COYA 303 is an investigational biologic combination of COYA 301, low-dose interleukin 2 and a GLP-1RA, designed to treat autoimmune and neurodegenerative diseases.

                            Product Name : Undisclosed

                            Product Type : Protein

                            Upfront Cash : Inapplicable

                            April 21, 2025

                            Lead Product(s) : COYA 301,Undisclosed

                            Therapeutic Area : Immunology

                            Highest Development Status : Preclinical

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            07

                            Earendil Labs

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                            ESCRS
                            Not Confirmed

                            Earendil Labs

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                            ESCRS
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                            Lead Product(s) : HXN-1002

                            Therapeutic Area : Immunology

                            Study Phase : Preclinical

                            Sponsor : Sanofi

                            Deal Size : $1,845.0 million

                            Deal Type : Licensing Agreement

                            DEALS_DEV arrow-down

                            Earendil Labs Licenses Bispecific Antibodies for Autoimmune use from Sanofi

                            Details : Under the licensing agreement, Sanofi will obtain exclusive worldwide rights to antibody, HXN-1002. It is designed to provide a treatment option for patients with ulcerative colitis.

                            Product Name : Undisclosed

                            Product Type : Antibody

                            Upfront Cash : $125.0 million

                            April 17, 2025

                            Lead Product(s) : HXN-1002

                            Therapeutic Area : Immunology

                            Highest Development Status : Preclinical

                            Sponsor : Sanofi

                            Deal Size : $1,845.0 million

                            Deal Type : Licensing Agreement

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                            08

                            Cue Biopharma

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                            ESCRS
                            Not Confirmed

                            Cue Biopharma

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                            Lead Product(s) : CUE-501

                            Therapeutic Area : Immunology

                            Study Phase : Preclinical

                            Sponsor : Boehringer Ingelheim GmbH

                            Deal Size : $357.0 million

                            Deal Type : Collaboration

                            DEALS_DEV arrow-down

                            Boehringer and Cue Biopharma Partner for Autoimmune and Inflammatory Disease Therapies

                            Details : The collaboration aims to accelerate the development of CUE-501, a bispecific designed to direct selective memory T cells to target and deplete B cells. It is being evaluated for autoimmune disease.

                            Product Name : Undisclosed

                            Product Type : Antibody

                            Upfront Cash : $12.0 million

                            April 14, 2025

                            Lead Product(s) : CUE-501

                            Therapeutic Area : Immunology

                            Highest Development Status : Preclinical

                            Sponsor : Boehringer Ingelheim GmbH

                            Deal Size : $357.0 million

                            Deal Type : Collaboration

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                            09

                            Tonix Pharmaceuticals Holding Corp

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                            ESCRS
                            Not Confirmed

                            Tonix Pharmaceuticals Holding Corp

                            U.S.A arrow
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                            Not Confirmed
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                            Lead Product(s) : TNX-1500,Undisclosed

                            Therapeutic Area : Immunology

                            Study Phase : Preclinical

                            Sponsor : Makana Therapeutics

                            Deal Size : Undisclosed

                            Deal Type : Collaboration

                            DEALS_DEV arrow-down

                            Tonix, Makana Partner On Anti-CD40L Antibody and Xenotransplantation

                            Details : Tonix and Makana will study Tonix’s anti-CD40L monoclonal antibody candidate, TNX-1500, in combination with Makana’s human-compatible organs and cells for the treatment of organ failure.

                            Product Name : Undisclosed

                            Product Type : Antibody

                            Upfront Cash : Undisclosed

                            April 09, 2025

                            Lead Product(s) : TNX-1500,Undisclosed

                            Therapeutic Area : Immunology

                            Highest Development Status : Preclinical

                            Sponsor : Makana Therapeutics

                            Deal Size : Undisclosed

                            Deal Type : Collaboration

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                            10

                            RayThera

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                            ESCRS
                            Not Confirmed

                            RayThera

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                            ESCRS
                            Not Confirmed
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                            Lead Product(s) : Undisclosed

                            Therapeutic Area : Immunology

                            Study Phase : Preclinical

                            Sponsor : Foresite Capital

                            Deal Size : $110.0 million

                            Deal Type : Series A Financing

                            DEALS_DEV arrow-down

                            RayThera Raises $110 Million in Series A Financing

                            Details : The proceeds from the financing will be used to advance RayThera’s lead drug candidates through Phase 1 clinical studies.

                            Product Name : Undisclosed

                            Product Type : Undisclosed

                            Upfront Cash : Undisclosed

                            April 04, 2025

                            Lead Product(s) : Undisclosed

                            Therapeutic Area : Immunology

                            Highest Development Status : Preclinical

                            Sponsor : Foresite Capital

                            Deal Size : $110.0 million

                            Deal Type : Series A Financing

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