Drugs in Dev.
Immunology
IND Enabling
China 
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Lead Product(s) : DNTH212
Therapeutic Area : Immunology
Study Phase : IND Enabling
Sponsor : Dianthus Therapeutics
Deal Size : $1,000.0 million
Deal Type : Licensing Agreement
Dianthus Therapeutics Licenses DNTH212 for Severe Autoimmune Diseases from Leads Biolabs
Details : Through the licensing deal for DNTH212, undisclosed company aims to target APRIL/BAFF/BDCA2 in severe autoimmune diseases.
Product Name : DNTH212
Product Type : Protein
Upfront Cash : $30.0 million
October 16, 2025
Lead Product(s) : DNTH212
Therapeutic Area : Immunology
Highest Development Status : IND Enabling
Sponsor : Dianthus Therapeutics
Deal Size : $1,000.0 million
Deal Type : Licensing Agreement

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Lead Product(s) : LBL-047
Therapeutic Area : Immunology
Study Phase : IND Enabling
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable
FDA Clears IND for LBL-047, an Anti-BDCA2/TACI Bispecific Fusion Protein by Leads Biolabs
Details : LBL-047 is a bispecific fusion protein composed of a humanized anti-blood dendritic cell antigen 2 (BDCA2) antibody and an engineered transmembrane activator and CAML interactor.
Product Name : LBL-047
Product Type : Protein
Upfront Cash : Inapplicable
September 22, 2025
Lead Product(s) : LBL-047
Therapeutic Area : Immunology
Highest Development Status : IND Enabling
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable

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Lead Product(s) : QT-019B
Therapeutic Area : Immunology
Study Phase : IND Enabling
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable
FDA Clears IND For Qihan’s QT-019B Dual-Target CAR-T In Lupus
Details : QT-019B is an off-the-shelf allogeneic CAR-T cell therapy targeting CD19 and BCMA for the treatment of for refractory systemic lupus erythematosus.
Product Name : QT-019B
Product Type : Cell & Gene Therapy
Upfront Cash : Inapplicable
August 18, 2025
Lead Product(s) : QT-019B
Therapeutic Area : Immunology
Highest Development Status : IND Enabling
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable

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Lead Product(s) : Velinotamig
Therapeutic Area : Immunology
Study Phase : IND Enabling
Sponsor : Cullinan Therapeutics
Deal Size : $712.0 million
Deal Type : Licensing Agreement
Cullinan's $700M Pact for BCMA Bispecific to Pair with Other TCE
Details : Under the licensing agreement, Cullinan will holds the exclusive rights to develop and commercialize GR-1803 (velinotamig) in all disease areas globally outside of Greater China.
Product Name : Undisclosed
Product Type : Undisclosed
Upfront Cash : $20.0 million
June 05, 2025
Lead Product(s) : Velinotamig
Therapeutic Area : Immunology
Highest Development Status : IND Enabling
Sponsor : Cullinan Therapeutics
Deal Size : $712.0 million
Deal Type : Licensing Agreement

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Lead Product(s) : NTB003
Therapeutic Area : Immunology
Study Phase : IND Enabling
Sponsor : Chia Tai Tianqing Pharmaceutical Group
Deal Size : Inapplicable
Deal Type : Inapplicable
Biocytogen and Nanjing Chia Tai Tianqing Announce IND Approval in China for NTB003
Details : NTB003 is a second-generation fully human anti-IGF-1R monoclonal antibody, being investigated for thyroid eye disease.
Product Name : Undisclosed
Product Type : Undisclosed
Upfront Cash : Inapplicable
June 04, 2025
Lead Product(s) : NTB003
Therapeutic Area : Immunology
Highest Development Status : IND Enabling
Sponsor : Chia Tai Tianqing Pharmaceutical Group
Deal Size : Inapplicable
Deal Type : Inapplicable

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Lead Product(s) : UC101
Therapeutic Area : Immunology
Study Phase : IND Enabling
Sponsor : VectorBuilder
Deal Size : Inapplicable
Deal Type : Inapplicable
VectorBuilder Enables FDA IND for Cord Blood CAR-T Therapy
Details : UC101 is the world’s first FDA IND-approved umbilical cord blood-derived allogeneic CAR-T therapy. It is being evaluated to alleviate the risk of host-versus-graft response.
Product Name : Undisclosed
Product Type : Cell & Gene Therapy
Upfront Cash : Inapplicable
January 29, 2025
Lead Product(s) : UC101
Therapeutic Area : Immunology
Highest Development Status : IND Enabling
Sponsor : VectorBuilder
Deal Size : Inapplicable
Deal Type : Inapplicable

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Lead Product(s) : LP-003
Therapeutic Area : Immunology
Study Phase : IND Enabling
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable
LongBio's LP-003 Achieves Its Fourth IND Approval
Details : LP-003 is the company's next-generation anti-IgE antibody. Currently, it is being evaluated in the early-stage clinical trial studies for the treatment of food allergy.
Product Name : Undisclosed
Product Type : Miscellaneous
Upfront Cash : Inapplicable
November 25, 2024
Lead Product(s) : LP-003
Therapeutic Area : Immunology
Highest Development Status : IND Enabling
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable

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Lead Product(s) : Equecabtagene Autoleucel
Therapeutic Area : Immunology
Study Phase : IND Enabling
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable
FDA Approves IASO Bio’s IND for Equecabtagene Autoleucel
Details : Fucaso (equecabtagene autoleucel) is a BCMA chimeric antigen receptor autologous T cell therapy, being investigated for the treatment of Non-renal Systemic Lupus Erythematosus.
Product Name : Undisclosed
Product Type : Cell & Gene Therapy
Upfront Cash : Inapplicable
August 12, 2024
Lead Product(s) : Equecabtagene Autoleucel
Therapeutic Area : Immunology
Highest Development Status : IND Enabling
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable

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Lead Product(s) : IASO-782
Therapeutic Area : Immunology
Study Phase : IND Enabling
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable
IASO Bio Receives NMPA IND Approval for IASO-782 in Systemic Lupus Erythematosus
Details : IASO-782 Injection is a fully human monoclonal antibody targeting human CD19, with Fc mutations to enhance ADCC function for treatment of Systemic Lupus Erythematosus.
Product Name : Undisclosed
Product Type : Miscellaneous
Upfront Cash : Inapplicable
July 25, 2024
Lead Product(s) : IASO-782
Therapeutic Area : Immunology
Highest Development Status : IND Enabling
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable

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Lead Product(s) : Equecabtagene Autoleucel
Therapeutic Area : Immunology
Study Phase : IND Enabling
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable
IASO Bio Announces FDA Approval for BCMA CAR-T Equecabtagene Autoleucel for MG
Details : CT103A (equecabtagene autoleucel) is a BCMA chimeric antigen receptor autologous T cell therapy, being investigated for the treatment of Generalized Myasthenia Gravis.
Product Name : Undisclosed
Product Type : Cell & Gene Therapy
Upfront Cash : Inapplicable
April 03, 2024
Lead Product(s) : Equecabtagene Autoleucel
Therapeutic Area : Immunology
Highest Development Status : IND Enabling
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable
