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Find Clinical Drug Pipeline Developments & Deals by ImCheck Therapeutics
The combination also demonstrated the activation, mobilization, and proliferation of CD8 T cells and NKs, with slightly more modest effects on granulocytes, in most patients at lower ICT01 doses than shown in previously presented data of ICT01 monotherapy in a similar patient.
Broad antitumor immune responses and demonstration of durable disease control from solid tumor patients who previously failed one or more checkpoint-inhibitor regimen, across a range of ICT01 doses in combination with pembrolizumab.
The proceeds will be used to support the Phase IIa expansion arms of EVICTION in solid tumors and hematologic cancers, and completion of placebo-controlled clinical trials evaluating ImCheck’s lead candidate ICT01 in combination with a PD-1 inhibitor for multiple solid tumors.
Clinical responses achieved with low doses of ICT01 in combination with pembrolizumab in solid tumor patients who previously failed checkpoint-inhibitor therapy support the complementary mechanisms of action with potential for anti-tumor activity.
Presented results demonstrating ICT01 plus pembrolizumab induced anti-tumor responses in patients with a range of solid tumors. 5 of 8 patients achieved disease control at 8 weeks and beyond according to RECIST1.1, including two partial responses at week 16 and beyond.
Lead Product(s):
Humanized anti-Butyrophilin 3A Monoclonal Antibody,Pembrolizumab
CT01 is a fully-humanized anti-BTN3A monoclonal antibody designed to selectively activate gamma 9 delta 2 (Vγ9Vδ2) T cells through all three isoforms of BTN3A (1/2/3). CT01 has been shown to have anti-tumor activity against a range of cancers.
Lead Product(s):
Humanized anti-Butyrophilin 3A Monoclonal Antibody,Pembrolizumab
ICT01 is a humanized, anti-BTN3A (CD277) monoclonal antibody that selectively activates γ9δ2 T cells. Monotherapy and combination of ICT01 and pembrolizumab, showed antitumor immune response against bladder cancer, metastatic melanoma and non-small cell lung cancer.
Lead Product(s):
Humanized anti-Butyrophilin 3A Monoclonal Antibody,Pembrolizumab
THOR-707, a precisely PEGylated, engineered version of IL-2 built on Sanofi’s Synthorin™ technology platform, is being studied in a trial of adults with advanced or metastatic solid tumors.
The data from the first cohort of six solid tumor cancer patients treated with ICT01 monotherapy demonstrated dose-dependent and specific γ9δ2 T cell activation and trafficking out of the circulation without dose-limiting toxicities or related serious adverse events.
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