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Find Clinical Drug Pipeline Developments & Deals by Ikena Oncology
The net proceeds will be used to expand and accelerate Ikena’s targeted oncology programs, including both IK-930, a TEAD1 selective Hippo pathway inhibitor, and IK-595, a MEK-RAF complexing inhibitor.
Through the acquisition, Ikena gains all of Pionyr’s assets including, PY314 and PY159, targeting TREM2 and TREM1 respectively, which are designed to selectively deplete and in some cases reprogram certain tumor-associated macrophages responsible for immunosuppression.
The Company anticipates the net proceeds to further its ongoing clinical development of targeted oncology programs, including IK-930, a novel TEAD inhibitor for the treatment of cancers in phase 1 clinical trial and IK-595, a MEK-RAF complex inhibitor.
IK-175 targets AHR, a compelling cancer-driving transcription factor that prevents immune recognition in a multitude of cancers by modulation of innate and adaptive immunity.
IK-595, a next-generation mitogen-activated protein kinase (MEK)-RAF complex inhibitor has been nominated as the company’s first development candidate in the RAS pathway.
IK-930 is an oral, paralog-selective TEAD inhibitor targeting the Hippo signaling pathway. IK-930 binds to TEAD transcription factors and prevents transcription of multiple genes that drive cancer progression.
IK-930 is an oral, paralog-selective TEAD inhibitor targeting the Hippo signaling pathway. IK-930 binds to TEAD transcription factors and prevents transcription of multiple genes that drive cancer progression.
IK-175 is an AHR (a compelling cancer-driving transcription factor) antagonist designed to modulate the tumor microenvironment, increasing both innate and adaptive immunity and offers a new opportunity for patients who cannot benefit from current standard-of-care treatments.
IK-930 binds to TEAD transcription factors to prevent transcription of multiple genes in Hippo pathway that are known to cause cancer progression, provide a novel targeted approach to address underlying biology driven by the genetic alterations that cause cancer pathogenesis.
IK-930 is an oral, selective TEAD inhibitor targeting Hippo signaling pathway, binds to TEAD transcription factors and prevents transcription of multiple genes that drive cancer progression and IK-175 is a selective, oral small molecule Aryl Hydrocarbon Receptor inhibitor.
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