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            Details:

            Through the acquisition, AstraZeneca will be able to access Icosavax’s IVX-A12, combination protein VLP vaccine which targets both RSV and human metapneumovirus, two leading causes of severe respiratory infections and hospitalizations in adults 60 years of age and older.

            Lead Product(s): IVX-A12

            Therapeutic Area: Infections and Infectious Diseases Product Name: IVX-A12

            Highest Development Status: Phase II Product Type: Vaccine

            Partner/Sponsor/Collaborator: AstraZeneca

            Deal Size: $1,100.0 million Upfront Cash: $1,100.0 million

            Deal Type: Acquisition February 19, 2024

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            Through the acquisition of Icosavax, AstraZeneca gains access to IVX-A12, a combination virus like particle (VLP) vaccine candidate targeting both respiratory syncytial virus (RSV) and human metapneumovirus (hMPV).

            Lead Product(s): IVX-A12

            Therapeutic Area: Infections and Infectious Diseases Product Name: IVX-A12

            Highest Development Status: Phase II Product Type: Vaccine

            Partner/Sponsor/Collaborator: AstraZeneca

            Deal Size: $1,100.0 million Upfront Cash: $1,100.0 million

            Deal Type: Acquisition December 12, 2023

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            IVX-A12 is a combination virus like particle (VLP) vaccine candidate targeting both respiratory syncytial virus (RSV) and human metapneumovirus (hMPV). It is under phase 2 clinical development.

            Lead Product(s): IVX-A12

            Therapeutic Area: Infections and Infectious Diseases Product Name: IVX-A12

            Highest Development Status: Phase II Product Type: Vaccine

            Partner/Sponsor/Collaborator: AstraZeneca

            Deal Size: Not Applicable Upfront Cash: Not Applicable

            Deal Type: Not Applicable December 12, 2023

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            IVX-A12 (IVX-121, IVX-241) is a vaccine drug candidate, which is being evaluated for the treatment of patients with respiratory syncytial virus infection in adults.

            Lead Product(s): IVX-121,IVX-241

            Therapeutic Area: Infections and Infectious Diseases Product Name: IVX-A12

            Highest Development Status: Phase II Product Type: Vaccine

            Partner/Sponsor/Collaborator: Not Applicable

            Deal Size: Not Applicable Upfront Cash: Not Applicable

            Deal Type: Not Applicable December 12, 2023

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            IVX-A12 is a potential first-in-class combination vaccine candidate containing VLPs that incorporate stabilized prefusion F proteins from RSV and hMPV viruses.

            Lead Product(s): IVX-121

            Therapeutic Area: Infections and Infectious Diseases Product Name: IVX-121

            Highest Development Status: Phase I Product Type: Vaccine

            Partner/Sponsor/Collaborator: Not Applicable

            Deal Size: Not Applicable Upfront Cash: Not Applicable

            Deal Type: Not Applicable August 08, 2023

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            IVX-A12 is a combination bivalent vaccine candidate against both respiratory syncytial virus and human metapneumovirus. IVX-A12 is comprised of IVX-121, Icosavax’s RSV prefusion F protein VLP and IVX-241, Icosavax’s hMPV prefusion F protein VLP vaccine candidate.

            Lead Product(s): IVX-121,IVX-241

            Therapeutic Area: Infections and Infectious Diseases Product Name: IVX-A12

            Highest Development Status: Phase II Product Type: Vaccine

            Partner/Sponsor/Collaborator: Not Applicable

            Deal Size: Not Applicable Upfront Cash: Not Applicable

            Deal Type: Not Applicable June 20, 2023

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            Details:

            IVX-A12 is a combination bivalent vaccine candidate against both respiratory syncytial virus and human metapneumovirus. IVX-A12 is comprised of IVX-121, Icosavax’s RSV prefusion F protein VLP and IVX-241, Icosavax’s hMPV prefusion F protein VLP vaccine candidate.

            Lead Product(s): IVX-121,IVX-241

            Therapeutic Area: Infections and Infectious Diseases Product Name: IVX-A12

            Highest Development Status: Phase I Product Type: Vaccine

            Partner/Sponsor/Collaborator: Not Applicable

            Deal Size: Not Applicable Upfront Cash: Not Applicable

            Deal Type: Not Applicable May 22, 2023

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            Details:

            IVX-A12 is a combination bivalent vaccine candidate against both respiratory syncytial virus and human metapneumovirus. IVX-A12 is comprised of IVX-121, Icosavax’s RSV prefusion F protein VLP and IVX-241, Icosavax’s hMPV prefusion F protein VLP vaccine candidate.

            Lead Product(s): IVX-121,IVX-241

            Therapeutic Area: Infections and Infectious Diseases Product Name: IVX-A12

            Highest Development Status: Phase I Product Type: Vaccine

            Partner/Sponsor/Collaborator: Not Applicable

            Deal Size: Not Applicable Upfront Cash: Not Applicable

            Deal Type: Not Applicable February 21, 2023

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            Details:

            In new data from Phase 1/1b study, IVX-121 showed sustained immunologic response at six months; geometric mean titers (GMT) against RSV-A through day 180 persisting at 64-98% of the GMTs at day 28 in older adults.

            Lead Product(s): IVX-121

            Therapeutic Area: Infections and Infectious Diseases Product Name: IVX-121

            Highest Development Status: Phase I Product Type: Vaccine

            Partner/Sponsor/Collaborator: Not Applicable

            Deal Size: Not Applicable Upfront Cash: Not Applicable

            Deal Type: Not Applicable December 13, 2022

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            Details:

            IVX-A12 is comprised of IVX-121, Icosavax’s RSV prefusion F protein VLP vaccine candidate, and IVX-241, Icosavax’s hMPV prefusion F protein VLP vaccine candidate.

            Lead Product(s): IVX-121,IVX-241

            Therapeutic Area: Infections and Infectious Diseases Product Name: IVX-A12

            Highest Development Status: Phase I Product Type: Vaccine

            Partner/Sponsor/Collaborator: Not Applicable

            Deal Size: Not Applicable Upfront Cash: Not Applicable

            Deal Type: Not Applicable October 04, 2022

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