

Lead Product(s) : Iadademstat
Therapeutic Area : Oncology
Study Phase : Phase I
Sponsor : Genentech | Oryzon Genomics
Deal Size : Inapplicable
Deal Type : Inapplicable
Iadademstat + SBRT with Atezo in ES-SCLC
Details : Iadademstat is a Other Small Molecule drug candidate, which is currently being evaluated in Phase I clinical studies for the treatment of Small Cell Lung Carcinoma.
Product Name : Undisclosed
Product Type : Miscellaneous
Upfront Cash : Inapplicable
August 11, 2025
Lead Product(s) : Iadademstat
Therapeutic Area : Oncology
Highest Development Status : Phase I
Sponsor : Genentech | Oryzon Genomics
Deal Size : Inapplicable
Deal Type : Inapplicable

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Lead Product(s) : Iadademstat
Therapeutic Area : Psychiatry/Psychology
Study Phase : Phase II
Sponsor : Med4Cure
Deal Size : $15.0 million
Deal Type : Funding
ORYZON Awarded €13.26 Million Through the First IPCEI in the Health Sector
Details : The proceeds will be used to accelerate the next steps in the clinical development of ORY-2001 (vafidemstat), an oral, CNS-optimized LSD1 inhibitor, for the treatment of CNS disorders.
Product Name : Undisclosed
Product Type : Miscellaneous
Upfront Cash : Undisclosed
May 08, 2025
Lead Product(s) : Iadademstat
Therapeutic Area : Psychiatry/Psychology
Highest Development Status : Phase II
Sponsor : Med4Cure
Deal Size : $15.0 million
Deal Type : Funding

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Lead Product(s) : Iadademstat,Atezolizumab,Durvalumab
Therapeutic Area : Oncology
Study Phase : Phase I/ Phase II
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable
ORYZON Doses First Patient in Lung Cancer Trial of Iadademstat with Checkpoint Drugs
Details : ORY-1001 (iadademstat) is a highly selective inhibitor of the epigenetic enzyme LSD1. It is being investigated in patients with extensive-stage small cell lung cancer.
Product Name : Undisclosed
Product Type : Miscellaneous
Upfront Cash : Inapplicable
April 15, 2025
Lead Product(s) : Iadademstat,Atezolizumab,Durvalumab
Therapeutic Area : Oncology
Highest Development Status : Phase I/ Phase II
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable

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Lead Product(s) : Iadademstat,Azacitidine,Venetoclax
Therapeutic Area : Oncology
Study Phase : Phase I
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable
ORYZON Doses First Patient in Phase I Study of Iadademstat in Myelodysplastic Syndrome
Details : ORY-1001 (iadademstat) is a highly selective inhibitor of the epigenetic enzyme LSD1. It is being investigated in patients with myelodysplastic syndrome.
Product Name : Undisclosed
Product Type : Miscellaneous
Upfront Cash : Inapplicable
January 23, 2025
Lead Product(s) : Iadademstat,Azacitidine,Venetoclax
Therapeutic Area : Oncology
Highest Development Status : Phase I
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable

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Lead Product(s) : Iadademstat,Azacitidine,Venetoclax
Therapeutic Area : Oncology
Study Phase : Phase I
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable
ORYZON Doses First Patient in Iadademstat- Venetoclax Trial for AML
Details : ORY-1001 (iadademstat) is a highly selective inhibitor of the epigenetic enzyme LSD1. It is being investigated in combination with venetoclax & azacitidine in patients with acute myeloid leukemia.
Product Name : Undisclosed
Product Type : Miscellaneous
Upfront Cash : Inapplicable
January 13, 2025
Lead Product(s) : Iadademstat,Azacitidine,Venetoclax
Therapeutic Area : Oncology
Highest Development Status : Phase I
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable

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Lead Product(s) : Iadademstat,Azacitidine,Venetoclax
Therapeutic Area : Oncology
Study Phase : Phase I
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable
ORYZON Doses First Patient in Phase Ib Study of Iadademstat for Acute Myeloid Leukemia
Details : ORY-1001 (iadademstat) is a highly selective inhibitor of the epigenetic enzyme LSD1. It is being investigated in combination with venetoclax & azacitidine in patients with acute myeloid leukemia.
Product Name : Undisclosed
Product Type : Miscellaneous
Upfront Cash : Inapplicable
September 09, 2024
Lead Product(s) : Iadademstat,Azacitidine,Venetoclax
Therapeutic Area : Oncology
Highest Development Status : Phase I
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable

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Lead Product(s) : Iadademstat,Durvalumab
Therapeutic Area : Oncology
Study Phase : Phase I/ Phase II
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable
ORYZON Receives FDA Clearance for Iadademstat Plus Checkpoint Inhibitors Trial
Details : ORY-1001 (iadademstat) is a selective LSD1 inhibitor investigated with immune checkpoint inhibitors in extensive disease small cell lung cancer patients.
Product Name : Undisclosed
Product Type : Miscellaneous
Upfront Cash : Inapplicable
April 08, 2024
Lead Product(s) : Iadademstat,Durvalumab
Therapeutic Area : Oncology
Highest Development Status : Phase I/ Phase II
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable

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Lead Product(s) : Iadademstat,Gilteritinib Fumarate
Therapeutic Area : Oncology
Study Phase : Phase I
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable
Details : ORY-1001 (iadademstat) is a highly selective inhibitor of the epigenetic enzyme LSD1 with powerful differentiating effect in hematologic cancer. It is being investigated in with gilteritinib for relapsed/refractory AML harboring a FMS-like tyrosine kinas...
Product Name : Undisclosed
Product Type : Miscellaneous
Upfront Cash : Inapplicable
March 15, 2023
Lead Product(s) : Iadademstat,Gilteritinib Fumarate
Therapeutic Area : Oncology
Highest Development Status : Phase I
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable

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Lead Product(s) : Iadademstat,Paclitaxel
Therapeutic Area : Oncology
Study Phase : Phase II
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable
Details : ORY-1001 (Iadademstat) is a small oral molecule, which acts as a highly selective inhibitor of the epigenetic enzyme LSD1 and has a powerful differentiating effect in hematologic cancers
Product Name : Undisclosed
Product Type : Miscellaneous
Upfront Cash : Inapplicable
January 18, 2023
Lead Product(s) : Iadademstat,Paclitaxel
Therapeutic Area : Oncology
Highest Development Status : Phase II
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable

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Lead Product(s) : Iadademstat,Undisclosed
Therapeutic Area : Oncology
Study Phase : Undisclosed
Sponsor : Eurostars
Deal Size : $0.4 million
Deal Type : Funding
Details : ORY-1001 (iadademstat) is a small oral molecule, which acts as a highly selective inhibitor of the epigenetic enzyme LSD1 and has a powerful differentiating effect in hematologic cancers.
Product Name : Undisclosed
Product Type : Miscellaneous
Upfront Cash : Undisclosed
December 16, 2022
Lead Product(s) : Iadademstat,Undisclosed
Therapeutic Area : Oncology
Highest Development Status : Undisclosed
Sponsor : Eurostars
Deal Size : $0.4 million
Deal Type : Funding
