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    [{"orgOrder":0,"company":"Astex Pharmaceuticals","sponsor":"Otsuka Pharmaceutical","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"U.S.A","productType":"Other Small Molecule","year":"2020","type":"Inapplicable","leadProduct":"Guadecitabine","moa":"nucleoside antiviral or antineoplastic agents","graph1":"Oncology","graph2":"Phase III","graph3":"Astex Pharmaceuticals","amount2":0,"highestDevelopmentShortName":"Ph III","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Injection","sponsorNew":"Astex Pharmaceuticals \/ Otsuka Pharmaceutical","highestDevelopmentStatusID":"10","companyTruncated":"Astex Pharmaceuticals \/ Otsuka Pharmaceutical"}]

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                            01

                            Astex Pharmaceuticals

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                            Astex Pharmaceuticals

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                            Lead Product(s) : Guadecitabine

                            Therapeutic Area : Oncology

                            Study Phase : Phase III

                            Sponsor : Otsuka Pharmaceutical

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Astex and Otsuka Announce Results of Phase 3 ASTRAL-2 and ASTRAL-3 Studies of Guadecitabine in Patients with P...

                            Details : Neither study met the primary endpoint of statistically significant (p <0.05) improvement in overall survival (OS) compared with the control arm of physicians’ choice of alternative therapy.

                            Product Name : Undisclosed

                            Product Type : Other Small Molecule

                            Upfront Cash : Inapplicable

                            October 14, 2020

                            Lead Product(s) : Guadecitabine

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase III

                            Sponsor : Otsuka Pharmaceutical

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            02

                            Shadia Jalal, MD

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                            ChemOutsourcing
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                            Shadia Jalal, MD

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                            ChemOutsourcing
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                            Lead Product(s) : Guadecitabine

                            Therapeutic Area : Oncology

                            Study Phase : Phase II

                            Sponsor : Astex Pharmaceuticals | Indiana University School of Medicine

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Guadecitabine in Combination With Carboplatin in Extensive Stage Small Cell Lung Cancer

                            Details : Undisclosed

                            Product Name : Undisclosed

                            Product Type : Other Small Molecule

                            Upfront Cash : Inapplicable

                            April 12, 2019

                            Lead Product(s) : Guadecitabine

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase II

                            Sponsor : Astex Pharmaceuticals | Indiana University School of Medicine

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            03

                            Astex Pharmaceuticals

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                            ChemOutsourcing
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                            Astex Pharmaceuticals

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                            Lead Product(s) : Guadecitabine

                            Therapeutic Area : Oncology

                            Study Phase : Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Guadecitabine Extension Study

                            Details : Undisclosed

                            Product Name : Undisclosed

                            Product Type : Other Small Molecule

                            Upfront Cash : Inapplicable

                            July 27, 2018

                            Lead Product(s) : Guadecitabine

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            04

                            University of Southern California

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                            ChemOutsourcing
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                            University of Southern California

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                            ChemOutsourcing
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                            Lead Product(s) : Guadecitabine

                            Therapeutic Area : Oncology

                            Study Phase : Phase I/ Phase II

                            Sponsor : National Cancer Institute | Bristol Myers Squibb | Astex Pharmaceuticals

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            Guadecitabine and Nivolumab in Treating Refractory Metastatic Colorectal Cancer

                            Details : Undisclosed

                            Product Name : Undisclosed

                            Product Type : Other Small Molecule

                            Upfront Cash : Inapplicable

                            July 05, 2018

                            Lead Product(s) : Guadecitabine

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase I/ Phase II

                            Sponsor : National Cancer Institute | Bristol Myers Squibb | Astex Pharmaceuticals

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            05

                            Groupe Francophone des Myelodysplasies

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                            ChemOutsourcing
                            Not Confirmed

                            Groupe Francophone des Myelodysplasies

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                            ChemOutsourcing
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                            Lead Product(s) : Guadecitabine

                            Therapeutic Area : Oncology

                            Study Phase : Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            SGI-110 and Donor Lymphocyte Infusions (DLI) After Allogeneic Stem Cell Transplantation

                            Details : Undisclosed

                            Product Name : Undisclosed

                            Product Type : Other Small Molecule

                            Upfront Cash : Inapplicable

                            March 06, 2018

                            Lead Product(s) : Guadecitabine

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            06

                            Ajjai Alva

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                            ChemOutsourcing
                            Not Confirmed

                            Ajjai Alva

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                            Lead Product(s) : Guadecitabine

                            Therapeutic Area : Oncology

                            Study Phase : Phase I/ Phase II

                            Sponsor : AstraZeneca | Big Ten Cancer Research Consortium

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Study of Durvalumab and Guadecitabine in Advanced Kidney Cancer

                            Details : Undisclosed

                            Product Name : Undisclosed

                            Product Type : Other Small Molecule

                            Upfront Cash : Inapplicable

                            October 12, 2017

                            Lead Product(s) : Guadecitabine

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase I/ Phase II

                            Sponsor : AstraZeneca | Big Ten Cancer Research Consortium

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            07

                            Royal Marsden NHS Foundation Trust

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                            ChemOutsourcing
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                            Royal Marsden NHS Foundation Trust

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                            ChemOutsourcing
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                            Lead Product(s) : Guadecitabine

                            Therapeutic Area : Oncology

                            Study Phase : Phase I

                            Sponsor : Astex Pharmaceuticals | Merck & Co | Institute of Cancer Research, United Kingdom

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Combination Study of Guadecitabine/ASTX727 and Pembrolizumab

                            Details : Undisclosed

                            Product Name : Undisclosed

                            Product Type : Other Small Molecule

                            Upfront Cash : Inapplicable

                            December 20, 2016

                            Lead Product(s) : Guadecitabine

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase I

                            Sponsor : Astex Pharmaceuticals | Merck & Co | Institute of Cancer Research, United Kingdom

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            08

                            Astex Pharmaceuticals

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                            ChemOutsourcing
                            Not Confirmed

                            Astex Pharmaceuticals

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                            ChemOutsourcing
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                            Lead Product(s) : Guadecitabine

                            Therapeutic Area : Oncology

                            Study Phase : Phase III

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Phase 3 Randomized, Open-Label Study of Guadecitabine vs Treatment Choice in Previously Treated Acute Myeloid ...

                            Details : Undisclosed

                            Product Name : Undisclosed

                            Product Type : Other Small Molecule

                            Upfront Cash : Inapplicable

                            September 30, 2016

                            Lead Product(s) : Guadecitabine

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase III

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            09

                            Astex Pharmaceuticals

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                            ChemOutsourcing
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                            Astex Pharmaceuticals

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                            ChemOutsourcing
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                            Lead Product(s) : Guadecitabine

                            Therapeutic Area : Oncology

                            Study Phase : Phase III

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Guadecitabine (SGI-110) vs Treatment Choice in Adults With MDS or CMML Previously Treated With HMAs

                            Details : Undisclosed

                            Product Name : Undisclosed

                            Product Type : Other Small Molecule

                            Upfront Cash : Inapplicable

                            September 20, 2016

                            Lead Product(s) : Guadecitabine

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase III

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            10

                            Northwestern University

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                            ChemOutsourcing
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                            Northwestern University

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                            Lead Product(s) : Guadecitabine

                            Therapeutic Area : Oncology

                            Study Phase : Phase II

                            Sponsor : Merck & Co | Astex Pharmaceuticals | National Cancer Institute

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Guadecitabine and Pembrolizumab in Treating Patients With Recurrent Ovarian, Primary Peritoneal, or Fallopian ...

                            Details : Undisclosed

                            Product Name : Undisclosed

                            Product Type : Other Small Molecule

                            Upfront Cash : Inapplicable

                            September 15, 2016

                            Lead Product(s) : Guadecitabine

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase II

                            Sponsor : Merck & Co | Astex Pharmaceuticals | National Cancer Institute

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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