
Year
DEALS // DEV.
Country
Therapeutic Area
Study Phase
Deal Type
Product Type
Dosage Form
Lead Product
Target

GT Biopharma Moves GTB-3650 Trial to Cohort 2 After Early Immune Activation
Details : GTB-3650 is an anti-CD16/IL-15/anti-CD33, being investigated for the treatment of relapsed or refractory (r/r) CD33 expressing hematologic malignancies.
Product Name : Undisclosed
Product Type : Antibody, Unconjugated
Upfront Cash : Inapplicable
May 19, 2025

GT Biopharma Doses First Patient in Phase 1 Trial of GTB-3650 in Hematologic Malignancies
Details : GTB-3650 is a second-generation TriKE, which is currently being evaluated for the treatment of relapsed or refractory (r/r) CD33 expressing hematologic malignancies.
Product Name : Undisclosed
Product Type : Antibody, Unconjugated
Upfront Cash : Inapplicable
January 27, 2025

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Lead Product(s) : GTB-3650
Therapeutic Area : Oncology
Study Phase : IND Enabling
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable
GT Biopharma Receives FDA IND Clearance for GTB-3650 NK Cell Engager in CD33+ Leukemia
Details : GTB-3650, a tri-specific molecule that binds to CD16 receptor utilizes company's proprietary TriKE platform, has recieved FDA clearance of IND application for CD33+ r/r AML and r/r high risk MDS.
Product Name : Undisclosed
Product Type : Antibody, Unconjugated
Upfront Cash : Inapplicable
June 27, 2024
Lead Product(s) : GTB-3650
Therapeutic Area : Oncology
Highest Development Status : IND Enabling
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable

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Lead Product(s) : GTB-3650
Therapeutic Area : Oncology
Study Phase : IND Enabling
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable
GT Biopharma Announces IND Submission for GTB-3650 for Treatment of CD33+ Leukemia
Details : GTB-3650 is a 2nd generation nanobody TriKE®, that binds the CD16 receptor on NK cells. It's IND application is submitted after the preclinical studies for the treatment of CD33+ leukemia, including r/r acute myelogenous leukemia & high-risk myelodyspla...
Product Name : Undisclosed
Product Type : Antibody, Unconjugated
Upfront Cash : Inapplicable
December 04, 2023
Lead Product(s) : GTB-3650
Therapeutic Area : Oncology
Highest Development Status : IND Enabling
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable

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Lead Product(s) : GTB-3650,Undisclosed
Therapeutic Area : Oncology
Study Phase : IND Enabling
Sponsor : Fate Therapeutics
Deal Size : Inapplicable
Deal Type : Inapplicable
Details : Preclinical data to be presented demonstrate that iPSC-derived, MICA/B-targeted CAR NK cells induced potent activity against AML cell line HL60, and further enhancement of activity was achieved in combination with GTB-3650 through antibody-dependent cell...
Product Name : Undisclosed
Product Type : Antibody, Unconjugated
Upfront Cash : Inapplicable
November 03, 2022
Lead Product(s) : GTB-3650,Undisclosed
Therapeutic Area : Oncology
Highest Development Status : IND Enabling
Sponsor : Fate Therapeutics
Deal Size : Inapplicable
Deal Type : Inapplicable

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Lead Product(s) : GTB-3550
Therapeutic Area : Oncology
Study Phase : Phase I/ Phase II
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable
Details : GTB-3550 is a single-chain, tri-specific scFv recombinant fusion protein conjugate composed of the variable regions of the heavy and light chains of anti-CD16 and anti-CD33 antibodies and human IL-15.
Product Name : Undisclosed
Product Type : Protein
Upfront Cash : Inapplicable
October 06, 2022
Lead Product(s) : GTB-3550
Therapeutic Area : Oncology
Highest Development Status : Phase I/ Phase II
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable

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Lead Product(s) : GTB-5550
Therapeutic Area : Oncology
Study Phase : Preclinical
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable
Details : GTB-5550 TriKE is a tri-specific molecule composed of a dual camelid nanobody that binds the CD16 receptor on NK cells, the single chain variable fragment (scFv) of an anti-B7H3 antibody, and human IL-15.
Product Name : Undisclosed
Product Type : Antibody, Unconjugated
Upfront Cash : Inapplicable
September 12, 2022
Lead Product(s) : GTB-5550
Therapeutic Area : Oncology
Highest Development Status : Preclinical
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable

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Lead Product(s) : GTB-3650
Therapeutic Area : Oncology
Study Phase : Preclinical
Sponsor : Cytovance Biologics
Deal Size : Undisclosed
Deal Type : Agreement
GT Biopharma Affirms Manufacturing Timeline For Lead Investigational Asset GTB-3650
Details : GTB-3650 is the Company's lead second-generation Tri-Specific Killer Engager TriKE ® program currently in preclinical development for the treatment of relapsed/refractory acute myelogenous leukemia (AML) and high-risk myelodysplastic syndrome (MDS).
Product Name : Undisclosed
Product Type : Antibody, Unconjugated
Upfront Cash : Undisclosed
August 30, 2022
Lead Product(s) : GTB-3650
Therapeutic Area : Oncology
Highest Development Status : Preclinical
Sponsor : Cytovance Biologics
Deal Size : Undisclosed
Deal Type : Agreement

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Lead Product(s) : GTB-7550
Therapeutic Area : Oncology
Study Phase : Preclinical
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable
Details : GTB-7550 (CAM-161519) is Company’s CD19-targeted TriKE targeted against B-cell lymphomas and is part of GT Biopharma’s portfolio of TriKE product candidates being investigated in several preclinical models against a broad class of solid tumors and he...
Product Name : Undisclosed
Product Type : Cell & Gene Therapy
Upfront Cash : Inapplicable
June 10, 2022
Lead Product(s) : GTB-7550
Therapeutic Area : Oncology
Highest Development Status : Preclinical
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable

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Lead Product(s) : GTB-5550
Therapeutic Area : Oncology
Study Phase : Preclinical
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable
Details : GTB-5550 is the Company’s B7H3-targeted tri-specific killer engager (TriKE) and is part of GT Biopharma’s portfolio of TriKE product candidates being investigated in several preclinical models against a broad class of solid tumor cancers.
Product Name : Undisclosed
Product Type : Antibody, Unconjugated
Upfront Cash : Inapplicable
April 11, 2022
Lead Product(s) : GTB-5550
Therapeutic Area : Oncology
Highest Development Status : Preclinical
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable
