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Diseases","country":"U.S.A","productType":"Miscellaneous","year":"2020","type":"Collaboration","leadProduct":"OXS-3550","moa":"CD16","graph1":"Infections and Infectious Diseases","graph2":"IND Enabling","graph3":"GT Biopharma","amount2":0,"highestDevelopmentShortName":"IND","therapeuticAreaShortName":"Infectious Diseases","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"GT Biopharma \/ GT Biopharma","highestDevelopmentStatusID":"5","companyTruncated":"GT Biopharma \/ GT Biopharma"},{"orgOrder":0,"company":"GT Biopharma","sponsor":"Fate Therapeutics","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"U.S.A","productType":"Antibody, Unconjugated","year":"2022","type":"Inapplicable","leadProduct":"GTB-3650","moa":"||CD33","graph1":"Oncology","graph2":"Phase I","graph3":"GT Biopharma","amount2":0,"highestDevelopmentShortName":"Ph I","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Infusion","sponsorNew":"GT Biopharma \/ Fate 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Biopharma","amount2":0,"highestDevelopmentShortName":"Ph I","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Infusion","sponsorNew":"GT Biopharma \/ Undisclosed","highestDevelopmentStatusID":"6","companyTruncated":"GT Biopharma \/ Undisclosed"},{"orgOrder":0,"company":"GT Biopharma","sponsor":"Undisclosed","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"U.S.A","productType":"Antibody, Unconjugated","year":"2024","type":"Inapplicable","leadProduct":"GTB-3650","moa":"CD33","graph1":"Oncology","graph2":"Phase I","graph3":"GT Biopharma","amount2":0,"highestDevelopmentShortName":"Ph I","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Infusion","sponsorNew":"GT Biopharma \/ Undisclosed","highestDevelopmentStatusID":"6","companyTruncated":"GT Biopharma \/ Undisclosed"},{"orgOrder":0,"company":"GT Biopharma","sponsor":"Cytovance Biologics","pharmaFlowCategory":"D","therapeuticArea":"Oncology","country":"U.S.A","productType":"Antibody, 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Undisclosed"},{"orgOrder":0,"company":"GT Biopharma","sponsor":"Undisclosed","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"U.S.A","productType":"Protein","year":"2017","type":"Inapplicable","leadProduct":"GTB-3550","moa":"Immunoglobulin gamma Fc receptor III (FCGR3)","graph1":"Oncology","graph2":"Phase I\/ Phase II","graph3":"GT Biopharma","amount2":0,"highestDevelopmentShortName":"Ph I\/II","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Infusion","sponsorNew":"GT Biopharma \/ Undisclosed","highestDevelopmentStatusID":"7","companyTruncated":"GT Biopharma \/ Undisclosed"},{"orgOrder":0,"company":"GT Biopharma","sponsor":"Undisclosed","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"U.S.A","productType":"Protein","year":"2022","type":"Inapplicable","leadProduct":"GTB-3550","moa":"Immunoglobulin gamma Fc receptor III (FCGR3)","graph1":"Oncology","graph2":"Phase I\/ Phase II","graph3":"GT 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Biopharma","amount2":0,"highestDevelopmentShortName":"Preclinical","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Injection","sponsorNew":"GT Biopharma \/ Undisclosed","highestDevelopmentStatusID":"4","companyTruncated":"GT Biopharma \/ Undisclosed"}]

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                          01

                          CPhI India
                          Not Confirmed
                          CPhI India
                          Not Confirmed

                          Details : GTB-3650 is an anti-CD16/IL-15/anti-CD33, being investigated for the treatment of relapsed or refractory (r/r) CD33 expressing hematologic malignancies.

                          Product Name : Undisclosed

                          Product Type : Antibody, Unconjugated

                          Upfront Cash : Inapplicable

                          May 19, 2025

                          Lead Product(s) : GTB-3650

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I

                          Sponsor : Undisclosed

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          02

                          CPhI India
                          Not Confirmed
                          CPhI India
                          Not Confirmed

                          Details : GTB-3650 is a second-generation TriKE, which is currently being evaluated for the treatment of relapsed or refractory (r/r) CD33 expressing hematologic malignancies.

                          Product Name : Undisclosed

                          Product Type : Antibody, Unconjugated

                          Upfront Cash : Inapplicable

                          January 27, 2025

                          Lead Product(s) : GTB-3650

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I

                          Sponsor : Undisclosed

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          03

                          CPhI India
                          Not Confirmed
                          CPhI India
                          Not Confirmed

                          Details : GTB-3650, a tri-specific molecule that binds to CD16 receptor utilizes company's proprietary TriKE platform, has recieved FDA clearance of IND application for CD33+ r/r AML and r/r high risk MDS.

                          Product Name : Undisclosed

                          Product Type : Antibody, Unconjugated

                          Upfront Cash : Inapplicable

                          June 27, 2024

                          Lead Product(s) : GTB-3650

                          Therapeutic Area : Oncology

                          Highest Development Status : IND Enabling

                          Sponsor : Undisclosed

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          04

                          CPhI India
                          Not Confirmed
                          CPhI India
                          Not Confirmed

                          Details : GTB-3650 is a 2nd generation nanobody TriKE®, that binds the CD16 receptor on NK cells. It's IND application is submitted after the preclinical studies for the treatment of CD33+ leukemia, including r/r acute myelogenous leukemia & high-risk myelodyspla...

                          Product Name : Undisclosed

                          Product Type : Antibody, Unconjugated

                          Upfront Cash : Inapplicable

                          December 04, 2023

                          Lead Product(s) : GTB-3650

                          Therapeutic Area : Oncology

                          Highest Development Status : IND Enabling

                          Sponsor : Undisclosed

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          05

                          CPhI India
                          Not Confirmed
                          CPhI India
                          Not Confirmed

                          Details : Preclinical data to be presented demonstrate that iPSC-derived, MICA/B-targeted CAR NK cells induced potent activity against AML cell line HL60, and further enhancement of activity was achieved in combination with GTB-3650 through antibody-dependent cell...

                          Product Name : Undisclosed

                          Product Type : Antibody, Unconjugated

                          Upfront Cash : Inapplicable

                          November 03, 2022

                          Lead Product(s) : GTB-3650,Undisclosed

                          Therapeutic Area : Oncology

                          Highest Development Status : IND Enabling

                          Sponsor : Fate Therapeutics

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          06

                          CPhI India
                          Not Confirmed
                          CPhI India
                          Not Confirmed

                          Details : GTB-3550 is a single-chain, tri-specific scFv recombinant fusion protein conjugate composed of the variable regions of the heavy and light chains of anti-CD16 and anti-CD33 antibodies and human IL-15.

                          Product Name : Undisclosed

                          Product Type : Protein

                          Upfront Cash : Inapplicable

                          October 06, 2022

                          Lead Product(s) : GTB-3550

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I/ Phase II

                          Sponsor : Undisclosed

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          07

                          CPhI India
                          Not Confirmed
                          CPhI India
                          Not Confirmed

                          Details : GTB-5550 TriKE is a tri-specific molecule composed of a dual camelid nanobody that binds the CD16 receptor on NK cells, the single chain variable fragment (scFv) of an anti-B7H3 antibody, and human IL-15.

                          Product Name : Undisclosed

                          Product Type : Antibody, Unconjugated

                          Upfront Cash : Inapplicable

                          September 12, 2022

                          Lead Product(s) : GTB-5550

                          Therapeutic Area : Oncology

                          Highest Development Status : Preclinical

                          Sponsor : Undisclosed

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          08

                          CPhI India
                          Not Confirmed
                          CPhI India
                          Not Confirmed

                          Details : GTB-3650 is the Company's lead second-generation Tri-Specific Killer Engager TriKE ® program currently in preclinical development for the treatment of relapsed/refractory acute myelogenous leukemia (AML) and high-risk myelodysplastic syndrome (MDS).

                          Product Name : Undisclosed

                          Product Type : Antibody, Unconjugated

                          Upfront Cash : Undisclosed

                          August 30, 2022

                          Lead Product(s) : GTB-3650

                          Therapeutic Area : Oncology

                          Highest Development Status : Preclinical

                          Sponsor : Cytovance Biologics

                          Deal Size : Undisclosed

                          Deal Type : Agreement

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                          09

                          CPhI India
                          Not Confirmed
                          CPhI India
                          Not Confirmed

                          Details : GTB-7550 (CAM-161519) is Company’s CD19-targeted TriKE targeted against B-cell lymphomas and is part of GT Biopharma’s portfolio of TriKE product candidates being investigated in several preclinical models against a broad class of solid tumors and he...

                          Product Name : Undisclosed

                          Product Type : Cell & Gene Therapy

                          Upfront Cash : Inapplicable

                          June 10, 2022

                          Lead Product(s) : GTB-7550

                          Therapeutic Area : Oncology

                          Highest Development Status : Preclinical

                          Sponsor : Undisclosed

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          10

                          CPhI India
                          Not Confirmed
                          CPhI India
                          Not Confirmed

                          Details : GTB-5550 is the Company’s B7H3-targeted tri-specific killer engager (TriKE) and is part of GT Biopharma’s portfolio of TriKE product candidates being investigated in several preclinical models against a broad class of solid tumor cancers.

                          Product Name : Undisclosed

                          Product Type : Antibody, Unconjugated

                          Upfront Cash : Inapplicable

                          April 11, 2022

                          Lead Product(s) : GTB-5550

                          Therapeutic Area : Oncology

                          Highest Development Status : Preclinical

                          Sponsor : Undisclosed

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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