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Find Clinical Drug Pipeline Developments & Deals by Gritstone bio
The proceeds will fund research and development of company's vaccine programs, including Granite, a personalized neoantigen-based vaccine, being evaluated in a Phase 2/3 study in patients with newly diagnosed, metastatic microsatellite-stable colorectal cancer.
Granite (GRT-C901/GRT-R902) is patient-specific neoantigen cancer vaccine. It is being evaluated in combination with immune checkpoint blockade in addition to fluoropyrimidine/bevacizumab for the treatment of front-line metastatic microsatellite stable colorectal cancer.
The net proceeds from the funding will be used by Gritstone for the advancement of Phase 2 study for GRT-R910, a self-amplifying mRNA vaccine candidate.
The net proceeds will be used to conduct a Phase 2b comparative study evaluating Gritstone’s self-amplifying mRNA (samRNA) vaccine candidate, GRT-R910, containing Spike plus other viral targets to protect against COVID-19.
Under the agreement, Gritstone will have a multi-year option for a non-exclusive license under Genevant’s LNP technology on a pathogen-by-pathogen basis to develop and commercialize self-amplifying RNA (samRNA) vaccines.
GRT-R910 is the vaccine is expected to boost and expand first-generation Covid-19 vaccines’ immunogenicity in people aged 60 years and above. GRT-R910 utilises a SAM vector formulated with lipid nanoparticles to deliver antigens against SARS-CoV-2 spike protein.
Under the terms of the agreement, NCI will identify patients with metastatic cancer that are eligible for adoptive cell transfer based on the presence of a G12V or G12D KRAS mutation (KRASmut).
Gritstone’s samRNA vectors enable extended duration and magnitude of antigen expression, in an immunostimulatory context, which together can drive more potent and durable induction of neutralizing antibodies and T cell immunity.
Gritstone intends to use the net proceeds from the PIPE financing to fund the ongoing clinical development of oncology and infectious disease programs including GRT-C901 and for general corporate purposes.
New data from CORAL-BOOST study for samRNA Covid-19 Vaccine demonstrate broad and durable immune response; high neutralizing antibody and T cell responses at 6 months post-boost vaccination.
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