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    [{"orgOrder":0,"company":"GRIN Therapeutics","sponsor":"Undisclosed","pharmaFlowCategory":"DU","therapeuticArea":"Neurology","country":"U.S.A","productType":"Miscellaneous","year":"2024","type":"Inapplicable","leadProduct":"Radiprodil","moa":"Glutamate NMDA receptor; GRIN1\/GRIN2B","graph1":"Neurology","graph2":"Phase I\/ Phase II","graph3":"GRIN Therapeutics","amount2":0,"highestDevelopmentShortName":"Ph I\/II","therapeuticAreaShortName":"Neurology","amount2New":0,"dosageForm":"Liquid, Suspension","sponsorNew":"GRIN Therapeutics \/ Undisclosed","highestDevelopmentStatusID":"7","companyTruncated":"GRIN Therapeutics \/ Undisclosed"},{"orgOrder":0,"company":"GRIN Therapeutics","sponsor":"Undisclosed","pharmaFlowCategory":"DU","therapeuticArea":"Neurology","country":"U.S.A","productType":"Miscellaneous","year":"2025","type":"Inapplicable","leadProduct":"Radiprodil","moa":"Glutamate NMDA receptor; GRIN1\/GRIN2B","graph1":"Neurology","graph2":"Phase I\/ Phase II","graph3":"GRIN Therapeutics","amount2":0,"highestDevelopmentShortName":"Ph I\/II","therapeuticAreaShortName":"Neurology","amount2New":0,"dosageForm":"Liquid, Suspension","sponsorNew":"GRIN Therapeutics \/ Undisclosed","highestDevelopmentStatusID":"7","companyTruncated":"GRIN Therapeutics \/ Undisclosed"},{"orgOrder":0,"company":"GRIN Therapeutics","sponsor":"Undisclosed","pharmaFlowCategory":"DU","therapeuticArea":"Neurology","country":"U.S.A","productType":"Miscellaneous","year":"2025","type":"Inapplicable","leadProduct":"Radiprodil","moa":"Glutamate NMDA receptor; 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    Find Clinical Drug Pipeline Developments & Deals by GRIN Therapeutics

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                            01

                            GRIN Therapeutics

                            U.S.A arrow
                            ISPE Annual Meeting
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                            GRIN Therapeutics

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                            ISPE Annual Meeting
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                            Lead Product(s) : Radiprodil

                            Therapeutic Area : Neurology

                            Study Phase : Phase I

                            Sponsor : Angelini Pharma

                            Deal Size : $570.0 million

                            Deal Type : Collaboration

                            DEALS_DEV arrow-down

                            GRIN and Angelini Partner to Develop Radiprodil Globally Except North America

                            Details : Angelini Pharma will receive exclusive rights to commercialize radiprodil, currently being studied in multiple rare genetic epilepsies and neurodevelopmental disorders, outside north america.

                            Product Name : Undisclosed

                            Product Type : Miscellaneous

                            Upfront Cash : $50.0 million

                            May 27, 2025

                            Lead Product(s) : Radiprodil

                            Therapeutic Area : Neurology

                            Highest Development Status : Phase I

                            Sponsor : Angelini Pharma

                            Deal Size : $570.0 million

                            Deal Type : Collaboration

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                            02

                            GRIN Therapeutics

                            U.S.A arrow
                            ISPE Annual Meeting
                            Not Confirmed

                            GRIN Therapeutics

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                            ISPE Annual Meeting
                            Not Confirmed
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                            Lead Product(s) : Radiprodil

                            Therapeutic Area : Rare Diseases and Disorders

                            Study Phase : Phase I

                            Sponsor : Avance Clinical

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Phase I Open-Label DDI Study of Radiprodil with Co-Administered Drugs

                            Details : Radiprodil is a Other Small Molecule drug candidate, which is currently being evaluated in Phase I clinical studies for the treatment of Tuberous Sclerosis.

                            Product Name : Undisclosed

                            Product Type : Miscellaneous

                            Upfront Cash : Inapplicable

                            May 16, 2025

                            Lead Product(s) : Radiprodil

                            Therapeutic Area : Rare Diseases and Disorders

                            Highest Development Status : Phase I

                            Sponsor : Avance Clinical

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            03

                            GRIN Therapeutics

                            U.S.A arrow
                            ISPE Annual Meeting
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                            GRIN Therapeutics

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                            ISPE Annual Meeting
                            Not Confirmed
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                            Lead Product(s) : Radiprodil

                            Therapeutic Area : Rare Diseases and Disorders

                            Study Phase : Phase I

                            Sponsor : Avance Clinical

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Study to Evaluate the Pharmacokinetics and Safety Effects Following Coadministration of Carbamazepine or Itrac...

                            Details : Radiprodil is a Other Small Molecule drug candidate, which is currently being evaluated in phase I clinical studies for the treatment of Tuberous Sclerosis.

                            Product Name : Undisclosed

                            Product Type : Miscellaneous

                            Upfront Cash : Inapplicable

                            May 11, 2025

                            Lead Product(s) : Radiprodil

                            Therapeutic Area : Rare Diseases and Disorders

                            Highest Development Status : Phase I

                            Sponsor : Avance Clinical

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            04

                            GRIN Therapeutics

                            U.S.A arrow
                            ISPE Annual Meeting
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                            GRIN Therapeutics

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                            ISPE Annual Meeting
                            Not Confirmed
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                            Lead Product(s) : Radiprodil

                            Therapeutic Area : Neurology

                            Study Phase : Phase I

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            GRIN gets EU Orphan Designation for Radiprodil in GRIN Neurodevelopmental Disorder

                            Details : Radiprodil is a potent negative allosteric modulator of the NMDA receptor subtype 2B. It is being evaluated for seizures associated with GRIN-related neurodevelopmental disorder with GoF mutations.

                            Product Name : Undisclosed

                            Product Type : Miscellaneous

                            Upfront Cash : Inapplicable

                            May 06, 2025

                            Lead Product(s) : Radiprodil

                            Therapeutic Area : Neurology

                            Highest Development Status : Phase I

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            05

                            GRIN Therapeutics

                            U.S.A arrow
                            ISPE Annual Meeting
                            Not Confirmed

                            GRIN Therapeutics

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                            ISPE Annual Meeting
                            Not Confirmed
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                            Lead Product(s) : Radiprodil

                            Therapeutic Area : Neurology

                            Study Phase : Phase I

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            GRIN Therapeutics Gets PRIME Designation From EMA for Radiprodil

                            Details : Radiprodil is a potent negative allosteric modulator of the NMDA receptor subtype 2B. It is being evaluated for seizures associated with GRIN-related neurodevelopmental disorder with GoF mutations.

                            Product Name : Undisclosed

                            Product Type : Miscellaneous

                            Upfront Cash : Inapplicable

                            April 01, 2025

                            Lead Product(s) : Radiprodil

                            Therapeutic Area : Neurology

                            Highest Development Status : Phase I

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            06

                            GRIN Therapeutics

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                            ISPE Annual Meeting
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                            GRIN Therapeutics

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                            ISPE Annual Meeting
                            Not Confirmed
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                            Lead Product(s) : Radiprodil

                            Therapeutic Area : Neurology

                            Study Phase : Phase I

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Grin Therapeutics Gets FDA Orphan Drug Tag for Radiprodil in Grin-Related Disorder

                            Details : Radiprodil is a potent negative allosteric modulator of the NMDA receptor subtype 2B. It is being evaluated for seizures associated with GRIN-related neurodevelopmental disorder with GoF mutations.

                            Product Name : Undisclosed

                            Product Type : Miscellaneous

                            Upfront Cash : Inapplicable

                            March 17, 2025

                            Lead Product(s) : Radiprodil

                            Therapeutic Area : Neurology

                            Highest Development Status : Phase I

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            07

                            GRIN Therapeutics

                            U.S.A arrow
                            ISPE Annual Meeting
                            Not Confirmed

                            GRIN Therapeutics

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                            ISPE Annual Meeting
                            Not Confirmed
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                            Lead Product(s) : Radiprodil

                            Therapeutic Area : Neurology

                            Study Phase : Phase I/ Phase II

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            GRIN Therapeutics Receives FDA Breakthrough Therapy Designation for Radiprodil

                            Details : Radiprodil is a potent negative allosteric modulator of the NMDA receptor subtype 2B. It is being evaluated for seizures associated with GRIN-related neurodevelopmental disorder with GoF mutations.

                            Product Name : Undisclosed

                            Product Type : Miscellaneous

                            Upfront Cash : Inapplicable

                            February 25, 2025

                            Lead Product(s) : Radiprodil

                            Therapeutic Area : Neurology

                            Highest Development Status : Phase I/ Phase II

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            08

                            GRIN Therapeutics

                            U.S.A arrow
                            ISPE Annual Meeting
                            Not Confirmed

                            GRIN Therapeutics

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                            ISPE Annual Meeting
                            Not Confirmed
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                            Lead Product(s) : Radiprodil

                            Therapeutic Area : Rare Diseases and Disorders

                            Study Phase : Phase I/ Phase II

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            GRIN Initiates Astroscape Trial of Radiprodil For Tuberous Sclerosis Complex

                            Details : Radiprodil is a potent negative allosteric modulator of the NMDA receptor subtype 2B. It is being evaluated for the treatment of Tuberous Sclerosis Complex and Focal Cortical Dysplasia Type II.

                            Product Name : Undisclosed

                            Product Type : Miscellaneous

                            Upfront Cash : Inapplicable

                            October 08, 2024

                            Lead Product(s) : Radiprodil

                            Therapeutic Area : Rare Diseases and Disorders

                            Highest Development Status : Phase I/ Phase II

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            09

                            GRIN Therapeutics

                            U.S.A arrow
                            ISPE Annual Meeting
                            Not Confirmed

                            GRIN Therapeutics

                            U.S.A arrow
                            ISPE Annual Meeting
                            Not Confirmed
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                            Lead Product(s) : Radiprodil

                            Therapeutic Area : Neurology

                            Study Phase : Phase I/ Phase II

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            GRIN Therapeutics Reports Positive Data from Honeycomb Trial of Radiprodil

                            Details : RGH-896 (radiprodil) is an investigational, selective and potent negative allosteric modulator of the N-methyl-D-aspartate receptor subtype 2B (NR2B or GluN2B).

                            Product Name : Undisclosed

                            Product Type : Miscellaneous

                            Upfront Cash : Inapplicable

                            September 09, 2024

                            Lead Product(s) : Radiprodil

                            Therapeutic Area : Neurology

                            Highest Development Status : Phase I/ Phase II

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            10

                            GRIN Therapeutics

                            U.S.A arrow
                            ISPE Annual Meeting
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                            GRIN Therapeutics

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                            ISPE Annual Meeting
                            Not Confirmed
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                            Lead Product(s) : Radiprodil

                            Therapeutic Area : Rare Diseases and Disorders

                            Study Phase : Phase I/ Phase II

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Astroscape: A Study of Radiprodil on Safety, Tolerability, Pharmacokinetics, and Effect on Seizures and Behavi...

                            Details : Radiprodil is a Other Small Molecule drug candidate, which is currently being evaluated in phase I/ phase II clinical studies for the treatment of Tuberous Sclerosis.

                            Product Name : Undisclosed

                            Product Type : Miscellaneous

                            Upfront Cash : Inapplicable

                            April 30, 2024

                            Lead Product(s) : Radiprodil

                            Therapeutic Area : Rare Diseases and Disorders

                            Highest Development Status : Phase I/ Phase II

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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