
 
													 
									 
															 
															Year
 
															DEALS // DEV.
 
															Country
 
															 
															Therapeutic Area
 
															Study Phase
 
															Deal Type
 
															Product Type
 
															Dosage Form
 
															Lead Product
 
															Target

Gradalis Gets FDA RMAT for Vigil® Immunotherapy in Advanced Ovarian Cancer
Details : Vigil (gemogenovatucel-T) a novel, triple function immunotherapy platform that modifies patient’s tumor by using bi-shRNA to reduce furin, being investigated for advanced Stage IIIb/IV ovarian cancer.
Product Name : Vigil
Product Type : Cell & Gene Therapy
Upfront Cash : Inapplicable
February 05, 2025

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Lead Product(s) : GRAD1405
Therapeutic Area : Oncology
Study Phase : Preclinical
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable
Gradalis' GRAD1405 Shows Positive Impact on KRAS Mutations in Resistant Cancers
Details : GRAD1405 utilizes Gradalis’ gene silencing bi-shRNAi technology to reduce mutated KRAS gene expression, under preclinical development for drug-resistant lung, colon, and pancreatic cancers.
Product Name : Undisclosed
Product Type : Miscellaneous
Upfront Cash : Inapplicable
January 04, 2024
Lead Product(s) : GRAD1405
Therapeutic Area : Oncology
Highest Development Status : Preclinical
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable

Gradalis Awarded $9.9 Million Grant from the Cancer Prevention and Research Institute of Texas
Details : The funds will be used to support the company's Phase 2 clinical study of Vigil (FANG vaccine), a novel, triple function immunotherapy platform, in platinum-sensitive patients who have recurrent ovarian cancer.
Product Name : Vigil
Product Type : Cell & Gene Therapy
Upfront Cash : Undisclosed
November 16, 2023

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Lead Product(s) : Gemogenovatucel-T,Atezolizumab
Therapeutic Area : Oncology
Study Phase : Phase II
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable
Details : Vigil® (gemogenovatucel-T) is a novel, personalized immunotherapy platform designed to achieve a Trifecta of immune anticancer activity using a unique bi-shRNA DNA-based plasmid and the patient's own tumor tissue.
Product Name : Vigil
Product Type : Cell & Gene Therapy
Upfront Cash : Inapplicable
December 21, 2022
Lead Product(s) : Gemogenovatucel-T,Atezolizumab
Therapeutic Area : Oncology
Highest Development Status : Phase II
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable

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Lead Product(s) : Gemogenovatucel-T,Atezolizumab
Therapeutic Area : Oncology
Study Phase : Phase II
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable
Details : Vigil® (gemogenovatucel-T) is a novel, personalized immunotherapy platform designed to achieve a Trifecta of immune anticancer activity using a unique bi-shRNA DNA based plasmid and the patient’s own tumor tissue.
Product Name : Vigil
Product Type : Cell & Gene Therapy
Upfront Cash : Inapplicable
September 28, 2022
Lead Product(s) : Gemogenovatucel-T,Atezolizumab
Therapeutic Area : Oncology
Highest Development Status : Phase II
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable

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Lead Product(s) : Gemogenovatucel-T,Atezolizumab
Therapeutic Area : Oncology
Study Phase : Phase II
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable
Details : Vigil (gemogenovatucel-T) is a novel, plasmid engineered, autologous tumor cell immunotherapy platform designed to achieve a trifecta of immune anticancer activity using a unique bi-shRNA DNA based technology and the patient’s own tumor tissue.
Product Name : Vigil
Product Type : Cell & Gene Therapy
Upfront Cash : Inapplicable
August 29, 2022
Lead Product(s) : Gemogenovatucel-T,Atezolizumab
Therapeutic Area : Oncology
Highest Development Status : Phase II
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable

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Lead Product(s) : Modafinil
Therapeutic Area : Oncology
Study Phase : Undisclosed
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable
Expanded Access of Vigil in Solid Tumors
Details : Vigil is a Cell and Gene Therapy drug candidate, which is currently being evaluated in clinical studies for the treatment of Neoplasms.
Product Name : Undisclosed
Product Type : Miscellaneous
Upfront Cash : Inapplicable
February 15, 2019
Lead Product(s) : Modafinil
Therapeutic Area : Oncology
Highest Development Status : Undisclosed
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable

Details : Vigil is a Cell and Gene Therapy drug candidate, which is currently being evaluated in phase III clinical studies for the treatment of Sarcoma, Ewing.
Product Name : Undisclosed
Product Type : Miscellaneous
Upfront Cash : Inapplicable
April 12, 2018

A Trial of Atezolizumab and Vigil in Patients With Advanced Gynecological Cancers
Details : Vigil is a Cell and Gene Therapy drug candidate, which is currently being evaluated in phase II clinical studies for the treatment of Genital Neoplasms, Female.
Product Name : Undisclosed
Product Type : Miscellaneous
Upfront Cash : Inapplicable
March 08, 2017

Pbi-shRNAâ„¢ EWS/FLI1 Type 1 LPX in Subjects With Advanced Ewing's Sarcoma
Details : Pbi-shRNA EWS/FLI1 Type 1 Lipoplex is a drug candidate, which is currently being evaluated in phase I clinical studies for the treatment of Sarcoma, Ewing.
Product Name : Undisclosed
Product Type : Undisclosed
Upfront Cash : Inapplicable
April 13, 2016

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