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                          Lead Product(s) : Aminolevulinic Acid HCl,Inapplicable

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                          Study Phase : Phase III

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                          Deal Type : Inapplicable

                          Details : Undisclosed

                          Product Name : Undisclosed

                          Product Type : Other Small Molecule

                          Upfront Cash : Inapplicable

                          December 07, 2023

                          Lead Product(s) : Aminolevulinic Acid HCl,Inapplicable

                          Therapeutic Area : Undisclosed

                          Highest Development Status : Phase III

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

                          Company Banner

                          02

                          Lead Product(s) : Aminolevulinic Acid HCl,Inapplicable

                          Therapeutic Area : Oncology

                          Study Phase : Phase I/ Phase II

                          Sponsor : IKP

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

                          Details : Undisclosed

                          Product Name : Undisclosed

                          Product Type : Other Small Molecule

                          Upfront Cash : Inapplicable

                          April 28, 2016

                          Lead Product(s) : Aminolevulinic Acid HCl,Inapplicable

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I/ Phase II

                          Sponsor : IKP

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

                          Company Banner

                          03

                          Costas Hadjipanayis

                          Country arrow
                          EPSC
                          Not Confirmed

                          Costas Hadjipanayis

                          Country arrow
                          EPSC
                          Not Confirmed

                          Lead Product(s) : Aminolevulinic Acid HCl,Inapplicable

                          Therapeutic Area : Oncology

                          Study Phase : Phase II

                          Sponsor : NX Development Corp | Southeastern Brain Tumor Foundation | StacheStrong Foundation | Neuroscience Research Foundation | University of Pittsburgh Medical Center | Advocate Hospital System

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

                          Details : Undisclosed

                          Product Name : Undisclosed

                          Product Type : Other Small Molecule

                          Upfront Cash : Inapplicable

                          April 02, 2025

                          Lead Product(s) : Aminolevulinic Acid HCl,Inapplicable

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase II

                          Sponsor : NX Development Corp | Southeastern Brain Tumor Foundation | StacheStrong Foundation | Neuroscience Research Foundation | University of Pittsburgh Medical Center | Advocate Hospital System

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          04

                          EPSC
                          Not Confirmed
                          EPSC
                          Not Confirmed

                          Details : Ameluz (Aminolevulinic HCl)is a topical gel, being investigated with the BF-RhodoLED lamp in the treatment of patients with superficial basal cell carcinoma.

                          Product Name : Ameluz

                          Product Type : Other Small Molecule

                          Upfront Cash : Inapplicable

                          March 18, 2025

                          Lead Product(s) : Aminolevulinic Acid HCl,Inapplicable

                          Therapeutic Area : Dermatology

                          Highest Development Status : Phase III

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          05

                          EPSC
                          Not Confirmed
                          EPSC
                          Not Confirmed

                          Details : Ameluz (Aminolevulinic HCl)is a topical gel, being investigated with the BF-RhodoLED lamp in the treatment of patients with superficial basal cell carcinoma.

                          Product Name : Ameluz

                          Product Type : Other Small Molecule

                          Upfront Cash : Inapplicable

                          January 08, 2025

                          Lead Product(s) : Aminolevulinic Acid HCl,Inapplicable

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase III

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          06

                          Psoriasis Treatment Center of Central New Jersey

                          Country arrow
                          EPSC
                          Not Confirmed

                          Psoriasis Treatment Center of Central New Jersey

                          Country arrow
                          EPSC
                          Not Confirmed

                          Details : Undisclosed

                          Product Name : Undisclosed

                          Product Type : Other Small Molecule

                          Upfront Cash : Inapplicable

                          December 24, 2024

                          Lead Product(s) : Aminolevulinic Acid HCl,Inapplicable

                          Therapeutic Area : Dermatology

                          Highest Development Status : Phase IV

                          Sponsor : Biofrontera

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          07

                          EPSC
                          Not Confirmed
                          EPSC
                          Not Confirmed

                          Details : Low-Intensity Diffuse Ultrasound with the sensitizing agent, oral 5-aminolevulinic acid (5-ALA) is being investigated in patients with recurrent or refractory high-grade gliomas.

                          Product Name : Undisclosed

                          Product Type : Other Small Molecule

                          Upfront Cash : Inapplicable

                          November 24, 2024

                          Lead Product(s) : Aminolevulinic Acid HCl,Inapplicable

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I/ Phase II

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          08

                          EPSC
                          Not Confirmed
                          EPSC
                          Not Confirmed

                          Details : The proceeds from this financing will primarily support Biofrontera’s commercial and clinical development initiatives including Ameluz (aminolevulinic acid) for superficial basal cell carcinoma.

                          Product Name : Ameluz

                          Product Type : Other Small Molecule

                          Upfront Cash : Undisclosed

                          November 22, 2024

                          Lead Product(s) : Aminolevulinic Acid HCl,Inapplicable

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase III

                          Sponsor : Undisclosed

                          Deal Size : $4.2 million

                          Deal Type : Private Placement

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                          09

                          EPSC
                          Not Confirmed
                          EPSC
                          Not Confirmed

                          Details : Ameluz (Aminolevulinic HCl)is a topical gel, being investigated with the BF-RhodoLED® lamp in the treatment of Superficial Basal Cell Carcinoma.

                          Product Name : Ameluz

                          Product Type : Other Small Molecule

                          Upfront Cash : Inapplicable

                          October 31, 2024

                          Lead Product(s) : Aminolevulinic Acid HCl,Inapplicable

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase III

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          10

                          Universität Münster

                          Country arrow
                          EPSC
                          Not Confirmed

                          Universität Münster

                          Country arrow
                          EPSC
                          Not Confirmed

                          Details : Undisclosed

                          Product Name : Undisclosed

                          Product Type : Other Small Molecule

                          Upfront Cash : Inapplicable

                          October 30, 2024

                          Lead Product(s) : Aminolevulinic Acid HCl,CV01

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I

                          Sponsor : Alpheus Medical

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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