
Year
DEALS // DEV.
Country
Therapeutic Area
Study Phase
Deal Type
Product Type
Dosage Form
Lead Product
Target

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Lead Product(s) : GNSC-001
Therapeutic Area : Musculoskeletal
Study Phase : Phase I
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable
Genascence’s GNSC-001 Safe in Phase 1b DONATELLO Knee OA Gene Therapy Trial
Details : GNSC-001 is a genetic medicine, a recombinant adeno-associated viral vector expressing an optimized human interleukin-1 receptor antagonist (IL-1Ra).
Product Name : Undisclosed
Product Type : Cell & Gene Therapy
Upfront Cash : Inapplicable
May 12, 2025
Lead Product(s) : GNSC-001
Therapeutic Area : Musculoskeletal
Highest Development Status : Phase I
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable

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Lead Product(s) : sc-rAAV2.5IL-1Ra
Therapeutic Area : Musculoskeletal
Study Phase : Phase I
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable
Genascence Granted FDA Fast Track Designation for GNSC-001 in OA
Details : GNSC-001 (sc-rAAV2.5IL-1Ra) is a recombinant adeno-associated viral vector expressing candidate that blocks IL-1 signaling, for the treatment of Knee Osteoarthritis.
Product Name : Undisclosed
Product Type : Cell & Gene Therapy
Upfront Cash : Inapplicable
November 12, 2024
Lead Product(s) : sc-rAAV2.5IL-1Ra
Therapeutic Area : Musculoskeletal
Highest Development Status : Phase I
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable

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Lead Product(s) : sc-rAAV2.5IL-1Ra
Therapeutic Area : Musculoskeletal
Study Phase : Phase I
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable
Genascence Initiates Phase 1b Trial Of GNSC-001 Gene Therapy
Details : GNSC-001 (sc-rAAV2.5IL-1Ra) is a genetic medicine using a viral vector to express IL-1Ra, blocking IL-1 signaling, and is in phase 1 development for Knee Osteoarthritis.
Product Name : Undisclosed
Product Type : Cell & Gene Therapy
Upfront Cash : Inapplicable
January 03, 2024
Lead Product(s) : sc-rAAV2.5IL-1Ra
Therapeutic Area : Musculoskeletal
Highest Development Status : Phase I
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable

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Lead Product(s) : GNSC-001
Therapeutic Area : Musculoskeletal
Study Phase : Phase I
Sponsor : California Institute for Regenerative Medicine (CIRM)
Deal Size : Inapplicable
Deal Type : Inapplicable
Safety and Pharmacodynamics of GNSC-001 Intra-articular Injection for Knee Osteoarthritis
Details : GNSC-001 is a Cell and Gene Therapy drug candidate, which is currently being evaluated in phase I clinical studies for the treatment of Osteoarthritis, Knee.
Product Name : Undisclosed
Product Type : Cell & Gene Therapy
Upfront Cash : Inapplicable
April 28, 2023
Lead Product(s) : GNSC-001
Therapeutic Area : Musculoskeletal
Highest Development Status : Phase I
Sponsor : California Institute for Regenerative Medicine (CIRM)
Deal Size : Inapplicable
Deal Type : Inapplicable

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Lead Product(s) : sc-rAAV2.5IL-1Ra
Therapeutic Area : Musculoskeletal
Study Phase : Phase II
Sponsor : Pacira BioSciences
Deal Size : $10.5 million
Deal Type : Series A Financing
Details : GNSC-001 is an adeno-associated vector (AAV) carrying a coding sequence for interleukin-1 receptor antagonist (IL-1Ra), a potent inhibitor of interleukin-1 (IL-1) signaling.
Product Name : Undisclosed
Product Type : Cell & Gene Therapy
Upfront Cash : Undisclosed
May 10, 2022
Lead Product(s) : sc-rAAV2.5IL-1Ra
Therapeutic Area : Musculoskeletal
Highest Development Status : Phase II
Sponsor : Pacira BioSciences
Deal Size : $10.5 million
Deal Type : Series A Financing
