[{"orgOrder":0,"company":"Genascence","sponsor":"Pacira BioSciences","pharmaFlowCategory":"D","therapeuticArea":"Musculoskeletal","country":"U.S.A","productType":"Cell & Gene Therapy","year":"2022","type":"Series A Financing","leadProduct":"sc-rAAV2.5IL-1Ra","moa":"IL-1 receptor","graph1":"Musculoskeletal","graph2":"Phase II","graph3":"Genascence","amount2":0.01,"highestDevelopmentShortName":"Ph II","therapeuticAreaShortName":"Musculoskeletal","amount2New":0.01,"dosageForm":"Injection","sponsorNew":"Genascence \/ Pacira BioSciences","highestDevelopmentStatusID":"8","companyTruncated":"Genascence \/ Pacira BioSciences"},{"orgOrder":0,"company":"Genascence","sponsor":"Undisclosed","pharmaFlowCategory":"DU","therapeuticArea":"Musculoskeletal","country":"U.S.A","productType":"Cell & Gene Therapy","year":"2024","type":"Inapplicable","leadProduct":"sc-rAAV2.5IL-1Ra","moa":"IL-1 receptor","graph1":"Musculoskeletal","graph2":"Phase II","graph3":"Genascence","amount2":0,"highestDevelopmentShortName":"Ph II","therapeuticAreaShortName":"Musculoskeletal","amount2New":0,"dosageForm":"Injection","sponsorNew":"Genascence \/ Undisclosed","highestDevelopmentStatusID":"8","companyTruncated":"Genascence \/ Undisclosed"},{"orgOrder":0,"company":"Genascence","sponsor":"Undisclosed","pharmaFlowCategory":"DU","therapeuticArea":"Musculoskeletal","country":"U.S.A","productType":"Cell & Gene Therapy","year":"2024","type":"Inapplicable","leadProduct":"sc-rAAV2.5IL-1Ra","moa":"IL-1 receptor","graph1":"Musculoskeletal","graph2":"Phase II","graph3":"Genascence","amount2":0,"highestDevelopmentShortName":"Ph II","therapeuticAreaShortName":"Musculoskeletal","amount2New":0,"dosageForm":"Injection","sponsorNew":"Genascence \/ Undisclosed","highestDevelopmentStatusID":"8","companyTruncated":"Genascence \/ Undisclosed"},{"orgOrder":0,"company":"Genascence","sponsor":"California Institute for Regenerative Medicine (CIRM)","pharmaFlowCategory":"DU","therapeuticArea":"Musculoskeletal","country":"U.S.A","productType":"Cell & Gene Therapy","year":"2023","type":"Inapplicable","leadProduct":"GNSC-001","moa":"Interleukin-1 receptor antagonist protein (IL1RN)","graph1":"Musculoskeletal","graph2":"Phase I","graph3":"Genascence","amount2":0,"highestDevelopmentShortName":"Ph I","therapeuticAreaShortName":"Musculoskeletal","amount2New":0,"dosageForm":"Injection","sponsorNew":"Genascence \/ California Institute for Regenerative Medicine (CIRM)","highestDevelopmentStatusID":"6","companyTruncated":"Genascence \/ California Institute for Regenerative Medicine (CIRM)"},{"orgOrder":0,"company":"Genascence","sponsor":"Undisclosed","pharmaFlowCategory":"DU","therapeuticArea":"Musculoskeletal","country":"U.S.A","productType":"Cell & Gene Therapy","year":"2025","type":"Inapplicable","leadProduct":"GNSC-001","moa":"Interleukin-1 receptor antagonist protein (IL1RN)","graph1":"Musculoskeletal","graph2":"Phase I","graph3":"Genascence","amount2":0,"highestDevelopmentShortName":"Ph I","therapeuticAreaShortName":"Musculoskeletal","amount2New":0,"dosageForm":"Injection","sponsorNew":"Genascence \/ Undisclosed","highestDevelopmentStatusID":"6","companyTruncated":"Genascence \/ Undisclosed"}]

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                          Therapeutic Area by Lead Product

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                          Top Deals by Deal Size (USD bn)

                          01

                          Global ChemShow
                          Not Confirmed
                          Global ChemShow
                          Not Confirmed

                          Details : GNSC-001 is a genetic medicine, a recombinant adeno-associated viral vector expressing an optimized human interleukin-1 receptor antagonist (IL-1Ra).

                          Product Name : Undisclosed

                          Product Type : Cell & Gene Therapy

                          Upfront Cash : Inapplicable

                          May 12, 2025

                          Lead Product(s) : GNSC-001

                          Therapeutic Area : Musculoskeletal

                          Highest Development Status : Phase I

                          Sponsor : Undisclosed

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          02

                          Global ChemShow
                          Not Confirmed
                          Global ChemShow
                          Not Confirmed

                          Details : GNSC-001 (sc-rAAV2.5IL-1Ra) is a recombinant adeno-associated viral vector expressing candidate that blocks IL-1 signaling, for the treatment of Knee Osteoarthritis.

                          Product Name : Undisclosed

                          Product Type : Cell & Gene Therapy

                          Upfront Cash : Inapplicable

                          November 12, 2024

                          Lead Product(s) : sc-rAAV2.5IL-1Ra

                          Therapeutic Area : Musculoskeletal

                          Highest Development Status : Phase I

                          Sponsor : Undisclosed

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          03

                          Global ChemShow
                          Not Confirmed
                          Global ChemShow
                          Not Confirmed

                          Details : GNSC-001 (sc-rAAV2.5IL-1Ra) is a genetic medicine using a viral vector to express IL-1Ra, blocking IL-1 signaling, and is in phase 1 development for Knee Osteoarthritis.

                          Product Name : Undisclosed

                          Product Type : Cell & Gene Therapy

                          Upfront Cash : Inapplicable

                          January 03, 2024

                          Lead Product(s) : sc-rAAV2.5IL-1Ra

                          Therapeutic Area : Musculoskeletal

                          Highest Development Status : Phase I

                          Sponsor : Undisclosed

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          04

                          Global ChemShow
                          Not Confirmed
                          Global ChemShow
                          Not Confirmed

                          Lead Product(s) : GNSC-001

                          Therapeutic Area : Musculoskeletal

                          Study Phase : Phase I

                          Sponsor : California Institute for Regenerative Medicine (CIRM)

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

                          Details : GNSC-001 is a Cell and Gene Therapy drug candidate, which is currently being evaluated in phase I clinical studies for the treatment of Osteoarthritis, Knee.

                          Product Name : Undisclosed

                          Product Type : Cell & Gene Therapy

                          Upfront Cash : Inapplicable

                          April 28, 2023

                          Lead Product(s) : GNSC-001

                          Therapeutic Area : Musculoskeletal

                          Highest Development Status : Phase I

                          Sponsor : California Institute for Regenerative Medicine (CIRM)

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          05

                          Global ChemShow
                          Not Confirmed
                          Global ChemShow
                          Not Confirmed

                          Details : GNSC-001 is an adeno-associated vector (AAV) carrying a coding sequence for interleukin-1 receptor antagonist (IL-1Ra), a potent inhibitor of interleukin-1 (IL-1) signaling.

                          Product Name : Undisclosed

                          Product Type : Cell & Gene Therapy

                          Upfront Cash : Undisclosed

                          May 10, 2022

                          Lead Product(s) : sc-rAAV2.5IL-1Ra

                          Therapeutic Area : Musculoskeletal

                          Highest Development Status : Phase II

                          Sponsor : Pacira BioSciences

                          Deal Size : $10.5 million

                          Deal Type : Series A Financing

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