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Find Novel Gastroenterology Drugs in Preclinical Development in UNITED STATES

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            Lead Product(s): HT-003

            Therapeutic Area: Gastroenterology Product Name: HT-003

            Highest Development Status: Preclinical Product Type: Small molecule

            Partner/Sponsor/Collaborator: Hoth Therapeutics

            Deal Size: Undisclosed Upfront Cash: Undisclosed

            Deal Type: Agreement March 11, 2021

            Details:

            Fresh explants of ulcerative colitis and Crohn's disease tissues obtained from surgical resection will be used as the test systems to investigate the therapeutic potential of the HT-003 drugs via measurement of key biomarkers for these diseases.

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            Lead Product(s): Undisclosed

            Therapeutic Area: Gastroenterology Product Name: Undisclosed

            Highest Development Status: Preclinical Product Type: Undisclosed

            Partner/Sponsor/Collaborator: Hatteras Venture

            Deal Size: $11.0 million Upfront Cash: Undisclosed

            Deal Type: Series A Financing March 01, 2021

            Details:

            Artizan will use the proceeds to continue advancing the preclinical research and development of its lead program for inflammatory bowel disease (“IBD”), which is anticipated to enter the clinic in 2022, as well as to explore additional disease targets.

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            Lead Product(s): Adalimumab

            Therapeutic Area: Gastroenterology Product Name: PGN-001

            Highest Development Status: Preclinical Product Type: Large molecule

            Partner/Sponsor/Collaborator: Not Applicable

            Deal Size: Not Applicable Upfront Cash: Not Applicable

            Deal Type: Not Applicable November 06, 2020

            Details:

            Progenity has two lead drug-device candidates utilizing the DDS technology, PGN-001, a high-concentration formulation of adalimumab, and PGN-600 a liquid formulation of tofacitinib, both under development for the treatment of ulcerative colitis.

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            Lead Product(s): PN-235

            Therapeutic Area: Gastroenterology Product Name: JNJ-77242113

            Highest Development Status: Preclinical Product Type: Peptide

            Partner/Sponsor/Collaborator: Janssen Pharmaceutical

            Deal Size: Undisclosed Upfront Cash: Undisclosed

            Deal Type: Collaboration October 29, 2020

            Details:

            The two new candidates, PN-235 (JNJ-77242113) and PN-232 (JNJ-75105186), are being developed as part of a portfolio strategy of discovering and developing oral IL-23 receptor antagonists.

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            Lead Product(s): SNSP003

            Therapeutic Area: Gastroenterology Product Name: SNSP003

            Highest Development Status: Preclinical Product Type: Large molecule

            Partner/Sponsor/Collaborator: CF Foundation

            Deal Size: $22.5 Million Upfront Cash: $14.0 million

            Deal Type: Funding October 20, 2020

            Details:

            The new funding will be used to advance preclinical development and early stage clinical trials for Synspira’s non-porcine enzyme replacement therapy, SNSP003.

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            Lead Product(s): ALV-304

            Therapeutic Area: Gastroenterology Product Name: ALV-304

            Highest Development Status: Preclinical Product Type: Undisclosed

            Partner/Sponsor/Collaborator: U.S. Department of Defense

            Deal Size: $3.3 million Upfront Cash: Undisclosed

            Deal Type: Funding October 05, 2020

            Details:

            The funds will support Alivio’s preclinical research and development activities to potentially enable the filing of an investigational new drug (IND) application for ALV-304.

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            Lead Product(s): RTX-1688

            Therapeutic Area: Gastroenterology Product Name: RTX-1688

            Highest Development Status: Preclinical Product Type: Small molecule

            Partner/Sponsor/Collaborator: Not Applicable

            Deal Size: Not Applicable Upfront Cash: Not Applicable

            Deal Type: Not Applicable August 31, 2020

            Details:

            Rodeo Therapeutics nominates Candidate RTX-1688, a first-in-class oral small molecule therapy for tissue regeneration and repair, with inflammatory bowel disease as the initial indication and platform potential in other disease settings .

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            Lead Product(s): PR600

            Therapeutic Area: Gastroenterology Product Name: PR600

            Highest Development Status: Preclinical Product Type: Large molecule

            Partner/Sponsor/Collaborator: Dr. Falk Pharma

            Deal Size: Undisclosed Upfront Cash: Undisclosed

            Deal Type: Collaboration August 13, 2020

            Details:

            Under the terms of the agreement, Prometheus and Falk will share responsibility for the global development of PR600, with Falk contributing one-quarter of the costs associated with developing PR600.

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            Lead Product(s): MORF-057

            Therapeutic Area: Gastroenterology Product Name: MORF-057

            Highest Development Status: Preclinical Product Type: Small molecule

            Partner/Sponsor/Collaborator: Not Applicable

            Deal Size: Not Applicable Upfront Cash: Not Applicable

            Deal Type: Not Applicable June 29, 2020

            Details:

            The data presented at DDW demonstrate that MORF-057 successfully targets the integrin α4β7 with high potency and selectivity.

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            Lead Product(s): Synthetic Biotic medicines

            Therapeutic Area: Gastroenterology Product Name: Undisclosed

            Highest Development Status: Preclinical Product Type: Undisclosed

            Partner/Sponsor/Collaborator: AbbVie Inc

            Deal Size: Undisclosed Upfront Cash: Undisclosed

            Deal Type: Termination May 21, 2020

            Details:

            Upon termination, Synlogic regains all rights to develop Synthetic Biotic medicines for the potential treatment of inflammatory bowel disease (IBD).