[{"orgOrder":0,"company":"Gain Therapeutics","sponsor":"Not Applicable","pharmaFlowCategory":"DU","amount":"Not Applicable","upfrontCash":"Not Applicable","newsHeadline":"Gain Therapeutics Presents Positive In Vitro & In Vivo Data on Its Star Compounds for GBA1 Parkinson\u2019s Disease & Related \u03b1-synucleopathies","therapeuticArea":"Neurology","highestDevelopmentStatus":"Preclinical","country":"U.S.A","productType":"Small molecule","productStatus":"New Molecular Entity","date":"May 2021","url1":"","url2":"","graph1":"Neurology","graph2":"Preclinical"},{"orgOrder":0,"company":"Gain Therapeutics","sponsor":"Not Applicable","pharmaFlowCategory":"DU","amount":"Not Applicable","upfrontCash":"Not Applicable","newsHeadline":"Gain Therapeutics Presents Preclinical Data on its Structurally Targeted Allosteric Regulators in GBA1 Gaucher Disease at the WORLDSymposium 2022","therapeuticArea":"Genetic Disease","highestDevelopmentStatus":"Preclinical","country":"U.S.A","productType":"Small 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Find Clinical Drug Pipeline Developments & Deals by Gain Therapeutics
GT-02287 is an orally administered, brain-penetrant small molecule is an allosteric protein modulator that restores the function of the lysosomal protein enzyme glucocerebrosidase (GCase). It is being evaluated for the treatment of GBA1 Parkinson’s Disease.
GT-00513 next generation of allosteric small molecule which works by restoring beta-galactosidase function. It is being evaluated for the treatment of GM1-gangliosidosis.
Gain intends to use the net proceeds to continue clinical and nonclinical development of its lead product candidate GT-02287 for the treatment of neurodegenerative diseases including GBA1 Parkinson’s disease.
Gain intends to use the net proceeds to continue clinical and nonclinical development of its lead product candidate GT-02287 for the treatment of neurodegenerative diseases including GBA1 Parkinson’s disease.
Gain intends to use the net proceeds to continue clinical and nonclinical development of its lead product candidate GT-02287 for the treatment of neurodegenerative diseases including GBA1 Parkinson’s disease.
GT-02287, an orally administered, brain-penetrant allosteric small molecule modulator of beta-glucocerebrosidase (GCase), Gain’s lead program for GBA1 Parkinson’s disease.
GT-02287, an orally administered, brain-penetrant allosteric small molecule modulator of beta-glucocerebrosidase (GCase), Gain’s lead program for GBA1 Parkinson’s disease.
The funding will be used to develop GT-02287, an orally administered, brain-penetrant allosteric small molecule modulator of beta-glucocerebrosidase (GCase), Gain’s lead program for GBA1 Parkinson’s disease.
The funds will advance the development of proprietary allosteric small molecule regulator against AAT Deficiency using computational discovery platform, SEE-Tx which is used to identify unknown allosteric binding sites on protein targets in CNS, oncology and metabolic disease.
GT-02287 is an allosteric regulator that is designed to increase GCase enzyme activity and decrease neuronal cell death to potentially become the first to develop a treatment for parkinson's disease.
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