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Find Clinical Drug Pipeline Developments & Deals by F-star Therapeutics

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                          Therapeutic Area by Lead Product

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                          Top Deals by Deal Size (USD bn)

                          01

                          Arvo
                          Not Confirmed
                          Arvo
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                          Details : FS118 is a dual checkpoint inhibitor targeting PD-L1 and LAG-3. FS118 is designed to provide unique pharmacology, that drives PD-L1 dependent LAG-3 shedding and receptor down-regulation, via bispecific activity, and potentially offering a more durable re...

                          Product Name : FS118

                          Product Type : Antibody

                          Upfront Cash : $161.0 million

                          August 03, 2023

                          Lead Product(s) : FS118

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I/ Phase II

                          Sponsor : Invox Pharma

                          Deal Size : $161.0 million

                          Deal Type : Acquisition

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                          02

                          Arvo
                          Not Confirmed
                          Arvo
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                          Details : Under the agreement, F-star will grant Takeda a worldwide, exclusive royalty-bearing licence to research, develop, and commercialize a bispecific antibody directed towards an undisclosed immuno-oncology target using F-star’s proprietary Fcab™ and mAb...

                          Product Name : Undisclosed

                          Product Type : Undisclosed

                          Upfront Cash : Undisclosed

                          March 22, 2023

                          Lead Product(s) : Undisclosed

                          Therapeutic Area : Oncology

                          Highest Development Status : Discovery

                          Sponsor : Takeda Pharmaceutical

                          Deal Size : Undisclosed

                          Deal Type : Licensing Agreement

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                          03

                          Arvo
                          Not Confirmed
                          Arvo
                          Not Confirmed

                          Details : Under the terms of the agreement, F-star will grant Takeda a worldwide, exclusive royalty-bearing license to research, develop, and commercialize a bispecific antibody against an immuno-oncology target using F-star’s proprietary Fcab™ and mAb2 ™ pl...

                          Product Name : Undisclosed

                          Product Type : Undisclosed

                          Upfront Cash : $1.0 million

                          July 20, 2022

                          Lead Product(s) : Undisclosed

                          Therapeutic Area : Oncology

                          Highest Development Status : Discovery

                          Sponsor : Takeda Pharmaceutical

                          Deal Size : $41.0 million

                          Deal Type : Licensing Agreement

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                          04

                          Arvo
                          Not Confirmed
                          Arvo
                          Not Confirmed

                          Details : FS118 is a first-in-class tetravalent bispecific antibody binding to LAG-3 and PD-L1, resulting in the reversal of immune suppression. FS118 was well tolerated with no treatment-related serious adverse events and no dose-limiting toxicity, up to 20mg/kg.

                          Product Name : FS118

                          Product Type : Antibody

                          Upfront Cash : Inapplicable

                          July 11, 2022

                          Lead Product(s) : FS118

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I/ Phase II

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          05

                          Arvo
                          Not Confirmed
                          Arvo
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                          Details : F-star’s unique next-generation tetravalent (2+2) bispecific antibody platform complements Sino Biopharm’s existing capabilities and reinforces its global oncology pipeline including FS118.

                          Product Name : FS118

                          Product Type : Antibody

                          Upfront Cash : $161.0 million

                          June 23, 2022

                          Lead Product(s) : FS118

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I/ Phase II

                          Sponsor : Invox Pharma

                          Deal Size : $161.0 million

                          Deal Type : Acquisition

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                          06

                          Arvo
                          Not Confirmed
                          Arvo
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                          Details : FS222 targets critical tumoral immune-suppressing pathways via PD-L1 checkpoint blockade and exhibited important costimulatory effect of potent clustering and activation of CD137, which in turn, promotes T cell activation and enhanced cytotoxic T cell re...

                          Product Name : FS222

                          Product Type : Antibody

                          Upfront Cash : Inapplicable

                          June 12, 2022

                          Lead Product(s) : FS222

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          07

                          Arvo
                          Not Confirmed
                          Arvo
                          Not Confirmed

                          Lead Product(s) : Undisclosed

                          Therapeutic Area : Oncology

                          Study Phase : Discovery

                          Sponsor : Johnson & Johnson Innovative Medicine

                          Deal Size : $1,367.5 million

                          Deal Type : Licensing Agreement

                          Details : Under the terms of the agreement, F-star will grant Janssen, a exclusive royalty-bearing license to research, develop, and commercialize up to five novel bispecific antibodies directed to Janssen therapeutic targets using F-star’s proprietary Fcab™ a...

                          Product Name : Undisclosed

                          Product Type : Undisclosed

                          Upfront Cash : $17.5 million

                          October 20, 2021

                          Lead Product(s) : Undisclosed

                          Therapeutic Area : Oncology

                          Highest Development Status : Discovery

                          Sponsor : Johnson & Johnson Innovative Medicine

                          Deal Size : $1,367.5 million

                          Deal Type : Licensing Agreement

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                          08

                          Arvo
                          Not Confirmed
                          Arvo
                          Not Confirmed

                          Details : FS120, a first-in-class OX40 and CD137 tetravalent dual T cell agonist used in patients with advanced malignancies. Safety and PK/PD data trigger initiation of the previously announced FS120 and KEYTRUDA® (pembrolizumab) combination study, scheduled to...

                          Product Name : FS120

                          Product Type : Antibody

                          Upfront Cash : Inapplicable

                          September 16, 2021

                          Lead Product(s) : FS120

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          09

                          Arvo
                          Not Confirmed
                          Arvo
                          Not Confirmed

                          Details : AstraZeneca will be responsible for all future research, development and commercialization of the STING inhibitor compounds, and F-star will retain rights to all STING agonists, currently in clinical development for patients with cancer.

                          Product Name : Undisclosed

                          Product Type : Undisclosed

                          Upfront Cash : $12.0 million

                          August 07, 2021

                          Lead Product(s) : Undisclosed

                          Therapeutic Area : Oncology

                          Highest Development Status : Preclinical

                          Sponsor : AstraZeneca

                          Deal Size : $312.0 million

                          Deal Type : Licensing Agreement

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                          10

                          Arvo
                          Not Confirmed
                          Arvo
                          Not Confirmed

                          Details : Under the terms of the agreement, AstraZeneca is granted exclusive access to F-star’s novel preclinical next generation Stimulator of Interferon Genes (STING) inhibitor compounds for its research, development and commercialization.

                          Product Name : Undisclosed

                          Product Type : Undisclosed

                          Upfront Cash : $12.0 million

                          August 07, 2021

                          Lead Product(s) : Undisclosed

                          Therapeutic Area : Oncology

                          Highest Development Status : Preclinical

                          Sponsor : AstraZeneca

                          Deal Size : $312.0 million

                          Deal Type : Licensing Agreement

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