
Year
DEALS // DEV.
Country
Therapeutic Area
Study Phase
Deal Type
Product Type
Dosage Form
Lead Product
Target

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Lead Product(s) : Masofaniten,Enzalutamide
Therapeutic Area : Oncology
Study Phase : Phase I/ Phase II
Sponsor : XenoTherapeutics
Deal Size : Undisclosed
Deal Type : Acquisition
Essa Pharma Inc. Updates Deal with XenoTherapeutics
Details : Through the acquisition , Xeno will leverage Essa pipeline, which consist of EPI-7386 (masofaniten), which is being evaluated for the treatment of prostate cancer.
Product Name : EPI-7386
Product Type : Miscellaneous
Upfront Cash : Undisclosed
September 24, 2025
Lead Product(s) : Masofaniten,Enzalutamide
Therapeutic Area : Oncology
Highest Development Status : Phase I/ Phase II
Sponsor : XenoTherapeutics
Deal Size : Undisclosed
Deal Type : Acquisition

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Lead Product(s) : Masofaniten,Enzalutamide
Therapeutic Area : Oncology
Study Phase : Phase II
Sponsor : XenoTherapeutics
Deal Size : Undisclosed
Deal Type : Acquisition
ESSA Pharma Announces Definitive Agreement to be Acquired by XenoTherapeutics
Details : XenoTherapeutics is acquiring ESSA Pharma to expand its pipeline by including, prostate cancer therapy EPI-7386 (masofaniten), a next-generation androgen receptor inhibitor.
Product Name : EPI-7386
Product Type : Miscellaneous
Upfront Cash : Undisclosed
July 14, 2025
Lead Product(s) : Masofaniten,Enzalutamide
Therapeutic Area : Oncology
Highest Development Status : Phase II
Sponsor : XenoTherapeutics
Deal Size : Undisclosed
Deal Type : Acquisition

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Lead Product(s) : Masofaniten,Enzalutamide
Therapeutic Area : Oncology
Study Phase : Phase I/ Phase II
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable
Essa Drops Lead Cancer Drug After Falling Short Against Xtandi
Details : EPI-7386 (masofaniten) is an oral, small molecule inhibitor of the N-terminal domain of the androgen receptor. Currently being studied in Combination with Enzalutamide in Patients with mCRPC.
Product Name : Undisclosed
Product Type : Miscellaneous
Upfront Cash : Inapplicable
November 01, 2024
Lead Product(s) : Masofaniten,Enzalutamide
Therapeutic Area : Oncology
Highest Development Status : Phase I/ Phase II
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable

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Lead Product(s) : Masofaniten,Enzalutamide
Therapeutic Area : Oncology
Study Phase : Phase I/ Phase II
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable
ESSA Pharma Presents Updated Phase 1/2 Data for Masofaniten at ESMO Congress
Details : EPI-7386 (masofaniten) is an oral, small molecule inhibitor of the N-terminal domain of the androgen receptor. Currently being studied in Combination with Enzalutamide in Patients with mCRPC.
Product Name : Undisclosed
Product Type : Miscellaneous
Upfront Cash : Inapplicable
September 13, 2024
Lead Product(s) : Masofaniten,Enzalutamide
Therapeutic Area : Oncology
Highest Development Status : Phase I/ Phase II
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable

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Lead Product(s) : Masofaniten
Therapeutic Area : Oncology
Study Phase : Phase II
Recipient : Pedro Barata, MD, MSc
Deal Size : Inapplicable
Deal Type : Inapplicable
Details : EPI-7386 is a Other Small Molecule drug candidate, which is currently being evaluated in phase II clinical studies for the treatment of Prostatic Neoplasms, Castration-Sensitive.
Product Name : Undisclosed
Product Type : Miscellaneous
Upfront Cash : Inapplicable
March 15, 2024
Lead Product(s) : Masofaniten
Therapeutic Area : Oncology
Highest Development Status : Phase II
Recipient : Pedro Barata, MD, MSc
Deal Size : Inapplicable
Deal Type : Inapplicable

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Lead Product(s) : Masofaniten,Enzalutamide
Therapeutic Area : Oncology
Study Phase : Phase I/ Phase II
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable
Details : EPI-7386 (masofaniten) is an investigational, highly-selective, oral, small molecule inhibitor of the N-terminal domain of the androgen receptor. It is currently being studied in Combination with Enzalutamide in Patients with Metastatic Castration-Resist...
Product Name : Undisclosed
Product Type : Miscellaneous
Upfront Cash : Inapplicable
September 18, 2023
Lead Product(s) : Masofaniten,Enzalutamide
Therapeutic Area : Oncology
Highest Development Status : Phase I/ Phase II
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable

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Lead Product(s) : Masofaniten,Abiraterone Acetate,Prednisone
Therapeutic Area : Oncology
Study Phase : Phase I
Sponsor : Johnson & Johnson Innovative Medicine
Deal Size : Undisclosed
Deal Type : Agreement
Details : ESSA will conduct a Phase 1 trial evaluating the safety, pharmacokinetics, drug-drug interactions, and preliminary anti-tumor activity of EPI-7386 when administered in combination with either apalutamide or abiraterone acetate plus prednisone in patients...
Product Name : Undisclosed
Product Type : Miscellaneous
Upfront Cash : Undisclosed
April 12, 2023
Lead Product(s) : Masofaniten,Abiraterone Acetate,Prednisone
Therapeutic Area : Oncology
Highest Development Status : Phase I
Sponsor : Johnson & Johnson Innovative Medicine
Deal Size : Undisclosed
Deal Type : Agreement

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Lead Product(s) : Masofaniten,Enzalutamide
Therapeutic Area : Oncology
Study Phase : Phase I/ Phase II
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable
Details : EPI-7386 is an investigational, highly-selective, oral, small molecule inhibitor of the N-terminal domain of the androgen receptor. It is currently being studied for CRPC whose tumors have progressed on standard-of-care therapies.
Product Name : Undisclosed
Product Type : Miscellaneous
Upfront Cash : Inapplicable
February 13, 2023
Lead Product(s) : Masofaniten,Enzalutamide
Therapeutic Area : Oncology
Highest Development Status : Phase I/ Phase II
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable

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Lead Product(s) : Masofaniten,Abiraterone Acetate,Prednisone
Therapeutic Area : Oncology
Study Phase : Phase I
Sponsor : Johnson & Johnson Innovative Medicine
Deal Size : Inapplicable
Deal Type : Inapplicable
ESSA Provides an Update on its Clinical Collaboration with Janssen
Details : EPI-7386 is an investigational, highly-selective, oral, small molecule inhibitor of the N-terminal domain of the androgen receptor. EPI-7386 is being studied in men with castration-resistant prostate cancer ("CRPC") whose tumors have progressed on standa...
Product Name : Undisclosed
Product Type : Miscellaneous
Upfront Cash : Inapplicable
October 31, 2022
Lead Product(s) : Masofaniten,Abiraterone Acetate,Prednisone
Therapeutic Area : Oncology
Highest Development Status : Phase I
Sponsor : Johnson & Johnson Innovative Medicine
Deal Size : Inapplicable
Deal Type : Inapplicable

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Lead Product(s) : EPI-8207
Therapeutic Area : Oncology
Study Phase : Preclinical
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable
Details : EPI-8207, an ANITAC, shows robust potency degrading AR, including AR splice variants and clinically relevant AR mutants that can potentially drive disease progression in patients with castration-resistant prostate cancer ("CRPC").
Product Name : Undisclosed
Product Type : Miscellaneous
Upfront Cash : Inapplicable
October 26, 2022
Lead Product(s) : EPI-8207
Therapeutic Area : Oncology
Highest Development Status : Preclinical
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable
