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    [{"orgOrder":0,"company":"Entos Pharmaceuticals","sponsor":"Not Applicable ","pharmaFlowCategory":"DU","amount":"Not Applicable","upfrontCash":"Not Applicable","newsHeadline":"Entos Pharmaceuticals Is Developing a DNA Vaccine Against COVID-19 Using Its Fusogenix Nanomedicine Platform","therapeuticArea":"Infections and Infectious Diseases","highestDevelopmentStatus":"Undisclosed","country":"U.S.A","productType":"Vaccine","productStatus":"New Molecular Entity","date":"March 2020","year":"2020","type":"Not Applicable","leadProduct":"Fusogenix DNA vaccine","moa":"","url1":"","url2":"","graph1":"Infections and Infectious Diseases","graph2":"Preclinical","graph3":"Entos Pharmaceuticals","amount2":0,"therapeuticAreaNew":"Infections and Infectious Diseases","highestDevelopmentStatusNew":"Preclinical","highestDevelopmentShortName":"Preclinical","therapeuticAreaShortName":"Infectious Diseases","productSubType":"","amount2New":0,"dosageForm":"","sponsorNew":"Entos Pharmaceuticals \/ Not 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    Find Clinical Drug Pipeline Developments & Deals by Entos Pharmaceuticals

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                            01

                            Entos Pharmaceuticals

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                            Lead Product(s) : Covigenix VAX-002

                            Therapeutic Area : Infections and Infectious Diseases

                            Study Phase : Phase I/ Phase II

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Entos Pharmaceuticals Doses First Participant in COVID-19 Vaccine Booster Trial

                            Details : Entos investigational product Covigenix VAX-002 is a plasmid DNA vaccine, which is being evaluated in the Phase 1/2 clinical trial studies to treat COVID-19.

                            Brand Name : Covigenix VAX-002

                            Molecule Type : Vaccine

                            Upfront Cash : Not Applicable

                            August 06, 2024

                            Lead Product(s) : Covigenix VAX-002

                            Therapeutic Area : Infections and Infectious Diseases

                            Highest Development Status : Phase I/ Phase II

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            02

                            Entos Pharmaceuticals

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                            BioProcess International
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                            Lead Product(s) : Covigenix VAX-002

                            Therapeutic Area : Infections and Infectious Diseases

                            Study Phase : Phase I/ Phase II

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Entos Gets Approval to Begin Clinical Trial for COVID-19 Vaccine Booster

                            Details : Entos investigational product Covigenix VAX-002 is a plasmid DNA vaccine, which is being evaluated in the Phase 1/2 clinical trial studies to treat COVID-19.

                            Brand Name : Covigenix VAX-002

                            Molecule Type : Vaccine

                            Upfront Cash : Not Applicable

                            June 10, 2024

                            Lead Product(s) : Covigenix VAX-002

                            Therapeutic Area : Infections and Infectious Diseases

                            Highest Development Status : Phase I/ Phase II

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            03

                            Entos Pharmaceuticals

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                            Lead Product(s) : Undisclosed

                            Therapeutic Area : Oncology

                            Study Phase : Preclinical

                            Sponsor : Alberta Cancer Foundation

                            Deal Size : $0.1 million

                            Deal Type : Funding

                            DEALS_DEV arrow-down

                            Alberta Cancer Foundation Announces Initial Investment of its Novel Philanthropic Breakthrough Fund to Support...

                            Details : The funding is intended to aid Entos in advancing a personalized immunotherapy strategy for treating cancer patients with advanced disease. This approach involves utilizing DNA vaccines tailored to target mutations present within the patients' own tumors...

                            Brand Name : Undisclosed

                            Molecule Type : Vaccine

                            Upfront Cash : Undisclosed

                            January 23, 2024

                            Lead Product(s) : Undisclosed

                            Therapeutic Area : Oncology

                            Highest Development Status : Preclinical

                            Sponsor : Alberta Cancer Foundation

                            Deal Size : $0.1 million

                            Deal Type : Funding

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                            04

                            Entos Pharmaceuticals

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                            BioProcess International
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                            Entos Pharmaceuticals

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                            Lead Product(s) : Nucleic acid-based Therapies

                            Therapeutic Area : Neurology

                            Study Phase : Preclinical

                            Sponsor : Eli Lilly

                            Deal Size : $450.0 million

                            Deal Type : Collaboration

                            DEALS_DEV arrow-down

                            Lilly and Entos Pharmaceuticals Enter into Research and Collaboration Agreement to Support the Development of ...

                            Details : Under the terms of the research and collaboration agreement, Lilly and Entos have agreed to multiple programs focused on the development of proteo-lipid vehicles (PLV) for delivery of therapeutic cargo supplied by Lilly to targets in the central and peri...

                            Brand Name : Undisclosed

                            Molecule Type : Large molecule

                            Upfront Cash : $50.0 million

                            January 06, 2022

                            Lead Product(s) : Nucleic acid-based Therapies

                            Therapeutic Area : Neurology

                            Highest Development Status : Preclinical

                            Sponsor : Eli Lilly

                            Deal Size : $450.0 million

                            Deal Type : Collaboration

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                            05

                            Entos Pharmaceuticals

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                            BioProcess International
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                            Lead Product(s) : Fusogenix-formulated Gene Therapy

                            Therapeutic Area : Genetic Disease

                            Study Phase : Undisclosed

                            Sponsor : BioMarin Pharmaceutical

                            Deal Size : Undisclosed

                            Deal Type : Agreement

                            DEALS_DEV arrow-down

                            Entos and BioMarin Enter into Agreement for Product Candidates Incorporating Entos' Fusogenix Drug Delivery Pl...

                            Details : Under the terms of the agreement, Entos will use its Fusogenix nucleic acid delivery system to specially formulate BioMarin products directed at multiple undisclosed genetic disease indications.

                            Brand Name : Undisclosed

                            Molecule Type : Cell and Gene therapy

                            Upfront Cash : Undisclosed

                            November 15, 2021

                            Lead Product(s) : Fusogenix-formulated Gene Therapy

                            Therapeutic Area : Genetic Disease

                            Highest Development Status : Undisclosed

                            Sponsor : BioMarin Pharmaceutical

                            Deal Size : Undisclosed

                            Deal Type : Agreement

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                            06

                            Entos Pharmaceuticals

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                            Lead Product(s) : Covigenix

                            Therapeutic Area : Infections and Infectious Diseases

                            Study Phase : Phase I

                            Sponsor : NRC IRAP

                            Deal Size : $5.0 million

                            Deal Type : Funding

                            DEALS_DEV arrow-down

                            Entos Pharmaceuticals Awarded Funding to Conduct Phase I Clinical Trial of COVID-19 DNA Vaccine

                            Details : Entos developed a Fusogenix DNA vaccine called Covigenix, that in preclinical studies, induces a strong neutralizing antibody response plus a potent and balanced T cell response against SARS-CoV-2, the virus that causes COVID-19.

                            Brand Name : Covigenix

                            Molecule Type : Vaccine

                            Upfront Cash : Undisclosed

                            October 23, 2020

                            Lead Product(s) : Covigenix

                            Therapeutic Area : Infections and Infectious Diseases

                            Highest Development Status : Phase I

                            Sponsor : NRC IRAP

                            Deal Size : $5.0 million

                            Deal Type : Funding

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                            07

                            Entos Pharmaceuticals

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                            BioProcess International
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                            Lead Product(s) : Fusogenix DNA vaccine

                            Therapeutic Area : Infections and Infectious Diseases

                            Study Phase : Preclinical

                            Sponsor : Canadian Institutes of Health Research (CIHR)

                            Deal Size : $4.2 million

                            Deal Type : Funding

                            DEALS_DEV arrow-down

                            Entos Pharmaceuticals Announces Selection of Lead DNA Vaccine Candidates for COVID-19 and a $4.2M Award

                            Details : Company announced the selection of two lead candidates for a pan-coronavirus Fusogenix DNA vaccine (Covigenix) from its prototyping program launched at the onset of the global COVID-19 pandemic.

                            Brand Name : Undisclosed

                            Molecule Type : Vaccine

                            Upfront Cash : Undisclosed

                            June 25, 2020

                            Lead Product(s) : Fusogenix DNA vaccine

                            Therapeutic Area : Infections and Infectious Diseases

                            Highest Development Status : Preclinical

                            Sponsor : Canadian Institutes of Health Research (CIHR)

                            Deal Size : $4.2 million

                            Deal Type : Funding

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                            08

                            Entos Pharmaceuticals

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                            BioProcess International
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                            Lead Product(s) : Covigenix

                            Therapeutic Area : Infections and Infectious Diseases

                            Study Phase : Preclinical

                            Recipient : GE Healthcare Inc

                            Deal Size : Undisclosed

                            Deal Type : Collaboration

                            DEALS_DEV arrow-down

                            Cytiva and Entos Pharmaceuticals work together to accelerate development of COVID19 vaccines

                            Details : Cytiva’s Fast Trak process development team will use their expertise to develop a scalable downstream protein purification method that will enable GMP-production of the Fusogenix protein component that facilitates intracellular DNA delivery.

                            Brand Name : Undisclosed

                            Molecule Type : Vaccine

                            Upfront Cash : Undisclosed

                            June 01, 2020

                            Lead Product(s) : Covigenix

                            Therapeutic Area : Infections and Infectious Diseases

                            Highest Development Status : Preclinical

                            Recipient : GE Healthcare Inc

                            Deal Size : Undisclosed

                            Deal Type : Collaboration

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                            09

                            Entos Pharmaceuticals

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                            BioProcess International
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                            Lead Product(s) : Fusogenix

                            Therapeutic Area : Infections and Infectious Diseases

                            Study Phase : Preclinical

                            Recipient : EpiVax

                            Deal Size : Undisclosed

                            Deal Type : Partnership

                            DEALS_DEV arrow-down

                            Epivax and Entos Pharmaceuticals to develop DNA-based vaccine for COVID-19

                            Details : This partnership will combine the Entos Fusogenix DNA delivery technology with optimized COVID-19 epitopes from EpiVax to generate a highly effective immune response against the novel coronavirus.

                            Brand Name : Undisclosed

                            Molecule Type : Vaccine

                            Upfront Cash : Undisclosed

                            April 28, 2020

                            Lead Product(s) : Fusogenix

                            Therapeutic Area : Infections and Infectious Diseases

                            Highest Development Status : Preclinical

                            Recipient : EpiVax

                            Deal Size : Undisclosed

                            Deal Type : Partnership

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                            10

                            Entos Pharmaceuticals

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                            BioProcess International
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                            Lead Product(s) : Fusogenix DNA vaccine

                            Therapeutic Area : Infections and Infectious Diseases

                            Study Phase : Undisclosed

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Entos Pharmaceuticals Is Developing a DNA Vaccine Against COVID-19 Using Its Fusogenix Nanomedicine Platform

                            Details : The vaccine payload will be plasmid DNA encoding multiple antigens from key SARS-CoV-2 proteins to promote maximum protection.

                            Brand Name : Undisclosed

                            Molecule Type : Vaccine

                            Upfront Cash : Not Applicable

                            March 18, 2020

                            Lead Product(s) : Fusogenix DNA vaccine

                            Therapeutic Area : Infections and Infectious Diseases

                            Highest Development Status : Undisclosed

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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