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    [{"orgOrder":0,"company":"Entos Pharmaceuticals","sponsor":"GE Healthcare Inc","pharmaFlowCategory":"D","therapeuticArea":"Infections and Infectious Diseases","country":"UNITED KINGDOM","productType":"Vaccine","year":"2020","type":"Collaboration","leadProduct":"Covigenix","moa":"Undisclosed","graph1":"Infections and Infectious Diseases","graph2":"Preclinical","graph3":"Entos Pharmaceuticals","amount2":0,"highestDevelopmentShortName":"Preclinical","therapeuticAreaShortName":"Infectious Diseases","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"Entos Pharmaceuticals \/ Entos Pharmaceuticals","highestDevelopmentStatusID":"4","companyTruncated":"Entos Pharmaceuticals \/ Entos Pharmaceuticals"},{"orgOrder":0,"company":"Entos Pharmaceuticals","sponsor":"NRC IRAP","pharmaFlowCategory":"D","therapeuticArea":"Infections and Infectious Diseases","country":"U.S.A","productType":"Vaccine","year":"2020","type":"Funding","leadProduct":"Covigenix","moa":"Undisclosed","graph1":"Infections 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                            01

                            Entos Pharmaceuticals

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                            Lead Product(s) : ENTLEP001

                            Therapeutic Area : Genetic Disease

                            Study Phase : IND Enabling

                            Sponsor : California Institute for Regenerative Medicine

                            Deal Size : $4.0 million

                            Deal Type : Funding

                            DEALS_DEV arrow-down

                            Entos Wins $4M CIRM Grant for Congenital Generalized Lipodystrophy Program

                            Details : The funds will support the completion of IND-enabling activities for the development of ENTLEP001, a durable genetic medicine for the treatment of congenital generalized lipodystrophy.

                            Product Name : Undisclosed

                            Product Type : Cell & Gene Therapy

                            Upfront Cash : Undisclosed

                            February 05, 2025

                            Lead Product(s) : ENTLEP001

                            Therapeutic Area : Genetic Disease

                            Highest Development Status : IND Enabling

                            Sponsor : California Institute for Regenerative Medicine

                            Deal Size : $4.0 million

                            Deal Type : Funding

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                            02

                            Entos Pharmaceuticals

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                            Lead Product(s) : Covigenix VAX-002

                            Therapeutic Area : Infections and Infectious Diseases

                            Study Phase : Phase I/ Phase II

                            Recipient : Aegis Life

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Aegis Completes Phase 1 Enrollment for COVID-19 Vaccine Booster Trial

                            Details : Covigenix VAX-002 is a plasmid DNA vaccine being evaluated in Phase 1/2 clinical trial studies to treat COVID-19.

                            Product Name : Undisclosed

                            Product Type : Vaccine

                            Upfront Cash : Inapplicable

                            September 19, 2024

                            Lead Product(s) : Covigenix VAX-002

                            Therapeutic Area : Infections and Infectious Diseases

                            Highest Development Status : Phase I/ Phase II

                            Recipient : Aegis Life

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            03

                            Entos Pharmaceuticals

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                            Lead Product(s) : Covigenix VAX-002

                            Therapeutic Area : Infections and Infectious Diseases

                            Study Phase : Phase I/ Phase II

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Entos Pharmaceuticals Doses First Participant in COVID-19 Vaccine Booster Trial

                            Details : Entos investigational product Covigenix VAX-002 is a plasmid DNA vaccine, which is being evaluated in the Phase 1/2 clinical trial studies to treat COVID-19.

                            Product Name : Undisclosed

                            Product Type : Vaccine

                            Upfront Cash : Inapplicable

                            August 06, 2024

                            Lead Product(s) : Covigenix VAX-002

                            Therapeutic Area : Infections and Infectious Diseases

                            Highest Development Status : Phase I/ Phase II

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            04

                            Entos Pharmaceuticals

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                            Lead Product(s) : Covigenix VAX-002

                            Therapeutic Area : Infections and Infectious Diseases

                            Study Phase : Phase I/ Phase II

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Entos Gets Approval to Begin Clinical Trial for COVID-19 Vaccine Booster

                            Details : Entos investigational product Covigenix VAX-002 is a plasmid DNA vaccine, which is being evaluated in the Phase 1/2 clinical trial studies to treat COVID-19.

                            Product Name : Undisclosed

                            Product Type : Vaccine

                            Upfront Cash : Inapplicable

                            June 10, 2024

                            Lead Product(s) : Covigenix VAX-002

                            Therapeutic Area : Infections and Infectious Diseases

                            Highest Development Status : Phase I/ Phase II

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            05

                            Entos Pharmaceuticals

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                            Lead Product(s) : Covigenix VAX-002

                            Therapeutic Area : Infections and Infectious Diseases

                            Study Phase : Phase I/ Phase II

                            Sponsor : Calian CRO | Q2 Solutions | PCI Pharma Services

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            To Evaluate Safety and Immunogenicity of a Prophylactic Plasmid DNA

                            Details : Covigenix VAX-002 is a Vaccine drug candidate, which is currently being evaluated in phase I/ phase II clinical studies for the treatment of COVID-19.

                            Product Name : Undisclosed

                            Product Type : Vaccine

                            Upfront Cash : Inapplicable

                            May 31, 2024

                            Lead Product(s) : Covigenix VAX-002

                            Therapeutic Area : Infections and Infectious Diseases

                            Highest Development Status : Phase I/ Phase II

                            Sponsor : Calian CRO | Q2 Solutions | PCI Pharma Services

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            06

                            Entos Pharmaceuticals

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                            Lead Product(s) : Undisclosed

                            Therapeutic Area : Oncology

                            Study Phase : Preclinical

                            Sponsor : Alberta Cancer Foundation

                            Deal Size : $0.1 million

                            Deal Type : Funding

                            DEALS_DEV arrow-down

                            Alberta Cancer Foundation Invests in Early-Stage Cancer Research Fund

                            Details : The funding will aid Entos in advancing personalized immunotherapy strategies utilizing DNA vaccines tailored to target mutations in patients' tumors for treating advanced cancer.

                            Product Name : Undisclosed

                            Product Type : Undisclosed

                            Upfront Cash : Undisclosed

                            January 23, 2024

                            Lead Product(s) : Undisclosed

                            Therapeutic Area : Oncology

                            Highest Development Status : Preclinical

                            Sponsor : Alberta Cancer Foundation

                            Deal Size : $0.1 million

                            Deal Type : Funding

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                            07

                            Entos Pharmaceuticals

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                            Lead Product(s) : Undisclosed

                            Therapeutic Area : Neurology

                            Study Phase : Preclinical

                            Sponsor : Eli Lilly

                            Deal Size : $450.0 million

                            Deal Type : Collaboration

                            DEALS_DEV arrow-down

                            Lilly and Entos Pharmaceuticals Enter into Research and Collaboration Agreement to Support the Development of ...

                            Details : Under the terms of the research and collaboration agreement, Lilly and Entos have agreed to multiple programs focused on the development of proteo-lipid vehicles (PLV) for delivery of therapeutic cargo supplied by Lilly to targets in the central and peri...

                            Product Name : Undisclosed

                            Product Type : Undisclosed

                            Upfront Cash : $50.0 million

                            January 06, 2022

                            Lead Product(s) : Undisclosed

                            Therapeutic Area : Neurology

                            Highest Development Status : Preclinical

                            Sponsor : Eli Lilly

                            Deal Size : $450.0 million

                            Deal Type : Collaboration

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                            08

                            Entos Pharmaceuticals

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                            Neuroscience
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                            Entos Pharmaceuticals

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                            Lead Product(s) : Undisclosed

                            Therapeutic Area : Genetic Disease

                            Study Phase : Undisclosed

                            Sponsor : BioMarin Pharmaceutical

                            Deal Size : Undisclosed

                            Deal Type : Agreement

                            DEALS_DEV arrow-down

                            Entos and BioMarin Enter into Agreement for Product Candidates Incorporating Entos' Fusogenix Drug Delivery Pl...

                            Details : Under the terms of the agreement, Entos will use its Fusogenix nucleic acid delivery system to specially formulate BioMarin products directed at multiple undisclosed genetic disease indications.

                            Product Name : Undisclosed

                            Product Type : Undisclosed

                            Upfront Cash : Undisclosed

                            November 15, 2021

                            Lead Product(s) : Undisclosed

                            Therapeutic Area : Genetic Disease

                            Highest Development Status : Undisclosed

                            Sponsor : BioMarin Pharmaceutical

                            Deal Size : Undisclosed

                            Deal Type : Agreement

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                            09

                            Entos Pharmaceuticals

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                            Neuroscience
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                            Lead Product(s) : Covigenix

                            Therapeutic Area : Infections and Infectious Diseases

                            Study Phase : Phase I

                            Sponsor : NRC IRAP

                            Deal Size : $5.0 million

                            Deal Type : Funding

                            DEALS_DEV arrow-down

                            Entos Pharmaceuticals Awarded Funding to Conduct Phase I Clinical Trial of COVID-19 DNA Vaccine

                            Details : Entos developed a Fusogenix DNA vaccine called Covigenix, that in preclinical studies, induces a strong neutralizing antibody response plus a potent and balanced T cell response against SARS-CoV-2, the virus that causes COVID-19.

                            Product Name : Covigenix

                            Product Type : Vaccine

                            Upfront Cash : Undisclosed

                            October 23, 2020

                            Lead Product(s) : Covigenix

                            Therapeutic Area : Infections and Infectious Diseases

                            Highest Development Status : Phase I

                            Sponsor : NRC IRAP

                            Deal Size : $5.0 million

                            Deal Type : Funding

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                            10

                            Entos Pharmaceuticals

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                            Lead Product(s) : Covigenix VAX-001

                            Therapeutic Area : Infections and Infectious Diseases

                            Study Phase : Phase I/ Phase II

                            Sponsor : Aegis Life | Canadian Institutes of Health Research | Clinical Pharma Solutions | Centre national de recherche et de formation sur le paludisme

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            A Clinical Trial of a Prophylactic Plasmid DNA Vaccine for COVID-19 [Covigenix VAX-001] in Adults

                            Details : Covigenix VAX-001 is a drug candidate, which is currently being evaluated in phase I/ phase II clinical studies for the treatment of SARS-CoV-2.

                            Product Name : Undisclosed

                            Product Type : Undisclosed

                            Upfront Cash : Inapplicable

                            October 19, 2020

                            Lead Product(s) : Covigenix VAX-001

                            Therapeutic Area : Infections and Infectious Diseases

                            Highest Development Status : Phase I/ Phase II

                            Sponsor : Aegis Life | Canadian Institutes of Health Research | Clinical Pharma Solutions | Centre national de recherche et de formation sur le paludisme

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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