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                          Top Deals by Deal Size (USD bn)

                          01

                          AGGSpend
                          Not Confirmed
                          AGGSpend
                          Not Confirmed

                          Details : The proceeds will accelerate the clinical and non-clinical development of PF614-MPAR, a next-generation opioid designed to offer powerful pain relief while dramatically reducing the risk of overdose.

                          Product Name : PF614-MPAR

                          Product Type : Controlled Substance

                          Upfront Cash : Undisclosed

                          June 04, 2025

                          Lead Product(s) : Oxycodone Prodrug,Nafamostat

                          Therapeutic Area : Neurology

                          Highest Development Status : Phase I

                          Sponsor : National Institute on Drug Abuse

                          Deal Size : $15.0 million

                          Deal Type : Funding

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                          02

                          AGGSpend
                          Not Confirmed
                          AGGSpend
                          Not Confirmed

                          Details : The net procceds from the offering will be used t fund clinical development of PF614 (oxycodone prodrug), which is being evaluated in the late-stage for the treatment of Acute Postoperative Pain.

                          Product Name : PF614

                          Product Type : Controlled Substance

                          Upfront Cash : Undisclosed

                          April 24, 2025

                          Lead Product(s) : Oxycodone Prodrug

                          Therapeutic Area : Neurology

                          Highest Development Status : Phase III

                          Sponsor : H.C. Wainwright & Co

                          Deal Size : $2.2 million

                          Deal Type : Public Offering

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                          03

                          AGGSpend
                          Not Confirmed
                          AGGSpend
                          Not Confirmed

                          Details : The net procceds from the offering will be used t fund clinical development of PF614 (oxycodone prodrug), which is being evaluated in the late-stage for the treatment of Acute Postoperative Pain.

                          Product Name : PF614

                          Product Type : Controlled Substance

                          Upfront Cash : Undisclosed

                          April 23, 2025

                          Lead Product(s) : Oxycodone Prodrug

                          Therapeutic Area : Neurology

                          Highest Development Status : Phase III

                          Sponsor : H.C. Wainwright & Co

                          Deal Size : $2.2 million

                          Deal Type : Public Offering

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                          04

                          AGGSpend
                          Not Confirmed
                          AGGSpend
                          Not Confirmed

                          Details : PF614 is a novel trypsin activated abuse protection (TAAP) prodrug of oxycodone. It is being evaluated in clinical trials for the treatment of severe and/or chronic pain.

                          Product Name : PF614

                          Product Type : Controlled Substance

                          Upfront Cash : Inapplicable

                          February 05, 2025

                          Lead Product(s) : Oxycodone Prodrug,Nafamostat

                          Therapeutic Area : Neurology

                          Highest Development Status : Phase I

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

                          blank

                          05

                          AGGSpend
                          Not Confirmed
                          AGGSpend
                          Not Confirmed

                          Details : PF614 is a novel trypsin activated abuse protection (TAAP) prodrug of oxycodone. It is being evaluated in clinical trials for the treatment of severe and/or chronic pain.

                          Product Name : PF614

                          Product Type : Controlled Substance

                          Upfront Cash : Inapplicable

                          January 22, 2025

                          Lead Product(s) : Oxycodone Prodrug,Nafamostat

                          Therapeutic Area : Neurology

                          Highest Development Status : Phase II

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          06

                          AGGSpend
                          Not Confirmed
                          AGGSpend
                          Not Confirmed

                          Details : PF614 is a novel trypsin activated abuse protection (TAAP) prodrug of oxycodone. It is being evaluated in phase 2 clinical trials for the treatment of severe and/or chronic pain.

                          Product Name : PF614

                          Product Type : Controlled Substance

                          Upfront Cash : Inapplicable

                          November 26, 2024

                          Lead Product(s) : Oxycodone Prodrug

                          Therapeutic Area : Neurology

                          Highest Development Status : Phase II

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          07

                          AGGSpend
                          Not Confirmed
                          AGGSpend
                          Not Confirmed

                          Details : The initiation of a strategic partnership with a leading specialty drug manufacturer for the development and commercial launch of PF614 for pain.

                          Product Name : PF614

                          Product Type : Controlled Substance

                          Upfront Cash : Undisclosed

                          April 12, 2024

                          Lead Product(s) : Oxycodone Prodrug

                          Therapeutic Area : Neurology

                          Highest Development Status : Phase II

                          Sponsor : Undisclosed

                          Deal Size : Undisclosed

                          Deal Type : Partnership

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                          08

                          AGGSpend
                          Not Confirmed
                          AGGSpend
                          Not Confirmed

                          Details : PF614 is a novel trypsin activated abuse protection (TAAP) prodrug of oxycodone. It is being evaluated in phase 2 clinical trials for the treatment of severe and/or chronic pain.

                          Product Name : PF614

                          Product Type : Controlled Substance

                          Upfront Cash : Inapplicable

                          January 31, 2024

                          Lead Product(s) : Oxycodone Prodrug

                          Therapeutic Area : Neurology

                          Highest Development Status : Phase II

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          09

                          AGGSpend
                          Not Confirmed
                          AGGSpend
                          Not Confirmed

                          Details : The financing will support the completion of a time of onset study and regulatory milestones for company's lead product, PF614, a novel trypsin activated abuse protection (TAAP) prodrug of oxycodone, being studied as chronic pain analgesic.

                          Product Name : PF614

                          Product Type : Controlled Substance

                          Upfront Cash : Undisclosed

                          October 24, 2023

                          Lead Product(s) : Oxycodone Prodrug

                          Therapeutic Area : Neurology

                          Highest Development Status : IND Enabling

                          Sponsor : Undisclosed

                          Deal Size : $1.7 million

                          Deal Type : Private Placement

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                          10

                          AGGSpend
                          Not Confirmed
                          AGGSpend
                          Not Confirmed

                          Details : PF614 is a chemically modified opioid product that requires initial metabolic transformation by trypsin in the small intestine for activation to be able to relieve severe pain in patients who require an opioid-level analgesic.

                          Product Name : PF614

                          Product Type : Controlled Substance

                          Upfront Cash : Inapplicable

                          September 08, 2023

                          Lead Product(s) : Oxycodone Prodrug

                          Therapeutic Area : Neurology

                          Highest Development Status : IND Enabling

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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