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Wainwright & Co","pharmaFlowCategory":"D","therapeuticArea":"Neurology","country":"U.S.A","productType":"Controlled Substance","year":"2025","type":"Public Offering","leadProduct":"Oxycodone Prodrug","moa":"Mu opioid receptor","graph1":"Neurology","graph2":"Phase III","graph3":"Ensysce Biosciences","amount2":0,"highestDevelopmentShortName":"Ph III","therapeuticAreaShortName":"Neurology","amount2New":0,"dosageForm":"Oral Capsule","sponsorNew":"Ensysce Biosciences \/ H.C. Wainwright & Co","highestDevelopmentStatusID":"10","companyTruncated":"Ensysce Biosciences \/ H.C. Wainwright & Co"}]

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                          01

                          AACR Annual meeting
                          Not Confirmed
                          AACR Annual meeting
                          Not Confirmed

                          Details : The net procceds from the offering will be used t fund clinical development of PF614 (oxycodone prodrug), which is being evaluated in the late-stage for the treatment of Acute Postoperative Pain.

                          Product Name : PF614

                          Product Type : Controlled Substance

                          Upfront Cash : Undisclosed

                          April 24, 2025

                          Lead Product(s) : Oxycodone Prodrug

                          Therapeutic Area : Neurology

                          Highest Development Status : Phase III

                          Sponsor : H.C. Wainwright & Co

                          Deal Size : $2.2 million

                          Deal Type : Public Offering

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                          02

                          AACR Annual meeting
                          Not Confirmed
                          AACR Annual meeting
                          Not Confirmed

                          Details : The net procceds from the offering will be used t fund clinical development of PF614 (oxycodone prodrug), which is being evaluated in the late-stage for the treatment of Acute Postoperative Pain.

                          Product Name : PF614

                          Product Type : Controlled Substance

                          Upfront Cash : Undisclosed

                          April 23, 2025

                          Lead Product(s) : Oxycodone Prodrug

                          Therapeutic Area : Neurology

                          Highest Development Status : Phase III

                          Sponsor : H.C. Wainwright & Co

                          Deal Size : $2.2 million

                          Deal Type : Public Offering

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                          03

                          AACR Annual meeting
                          Not Confirmed
                          AACR Annual meeting
                          Not Confirmed

                          Details : PF614 is a novel trypsin activated abuse protection (TAAP) prodrug of oxycodone. It is being evaluated in clinical trials for the treatment of severe and/or chronic pain.

                          Product Name : PF614

                          Product Type : Controlled Substance

                          Upfront Cash : Inapplicable

                          February 05, 2025

                          Lead Product(s) : Oxycodone Prodrug,Nafamostat

                          Therapeutic Area : Neurology

                          Highest Development Status : Phase I

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          04

                          AACR Annual meeting
                          Not Confirmed
                          AACR Annual meeting
                          Not Confirmed

                          Details : PF614 is a novel trypsin activated abuse protection (TAAP) prodrug of oxycodone. It is being evaluated in clinical trials for the treatment of severe and/or chronic pain.

                          Product Name : PF614

                          Product Type : Controlled Substance

                          Upfront Cash : Inapplicable

                          January 22, 2025

                          Lead Product(s) : Oxycodone Prodrug,Nafamostat

                          Therapeutic Area : Neurology

                          Highest Development Status : Phase II

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          05

                          AACR Annual meeting
                          Not Confirmed
                          AACR Annual meeting
                          Not Confirmed

                          Details : PF614 is a novel trypsin activated abuse protection (TAAP) prodrug of oxycodone. It is being evaluated in phase 2 clinical trials for the treatment of severe and/or chronic pain.

                          Product Name : PF614

                          Product Type : Controlled Substance

                          Upfront Cash : Inapplicable

                          November 26, 2024

                          Lead Product(s) : Oxycodone Prodrug

                          Therapeutic Area : Neurology

                          Highest Development Status : Phase II

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          06

                          AACR Annual meeting
                          Not Confirmed
                          AACR Annual meeting
                          Not Confirmed

                          Details : The initiation of a strategic partnership with a leading specialty drug manufacturer for the development and commercial launch of PF614 for pain.

                          Product Name : PF614

                          Product Type : Controlled Substance

                          Upfront Cash : Undisclosed

                          April 12, 2024

                          Lead Product(s) : Oxycodone Prodrug

                          Therapeutic Area : Neurology

                          Highest Development Status : Phase II

                          Sponsor : Undisclosed

                          Deal Size : Undisclosed

                          Deal Type : Partnership

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                          07

                          AACR Annual meeting
                          Not Confirmed
                          AACR Annual meeting
                          Not Confirmed

                          Details : PF614 is a novel trypsin activated abuse protection (TAAP) prodrug of oxycodone. It is being evaluated in phase 2 clinical trials for the treatment of severe and/or chronic pain.

                          Product Name : PF614

                          Product Type : Controlled Substance

                          Upfront Cash : Inapplicable

                          January 31, 2024

                          Lead Product(s) : Oxycodone Prodrug

                          Therapeutic Area : Neurology

                          Highest Development Status : Phase II

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          08

                          AACR Annual meeting
                          Not Confirmed
                          AACR Annual meeting
                          Not Confirmed

                          Details : The financing will support the completion of a time of onset study and regulatory milestones for company's lead product, PF614, a novel trypsin activated abuse protection (TAAP) prodrug of oxycodone, being studied as chronic pain analgesic.

                          Product Name : PF614

                          Product Type : Controlled Substance

                          Upfront Cash : Undisclosed

                          October 24, 2023

                          Lead Product(s) : Oxycodone Prodrug

                          Therapeutic Area : Neurology

                          Highest Development Status : IND Enabling

                          Sponsor : Undisclosed

                          Deal Size : $1.7 million

                          Deal Type : Private Placement

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                          09

                          AACR Annual meeting
                          Not Confirmed
                          AACR Annual meeting
                          Not Confirmed

                          Details : PF614 is a chemically modified opioid product that requires initial metabolic transformation by trypsin in the small intestine for activation to be able to relieve severe pain in patients who require an opioid-level analgesic.

                          Product Name : PF614

                          Product Type : Controlled Substance

                          Upfront Cash : Inapplicable

                          September 08, 2023

                          Lead Product(s) : Oxycodone Prodrug

                          Therapeutic Area : Neurology

                          Highest Development Status : IND Enabling

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          10

                          AACR Annual meeting
                          Not Confirmed
                          AACR Annual meeting
                          Not Confirmed

                          Details : PF614-MPAR (oxycodone prodrug) binds and inhibits adenylyl-cyclase and hyperpolarisation of neurons, and decreased excitability, thus reduces severe pain. It is the first opioid drug product that has both abuse deterrent properties as well as overdose pr...

                          Product Name : PF614

                          Product Type : Controlled Substance

                          Upfront Cash : Inapplicable

                          February 14, 2023

                          Lead Product(s) : Oxycodone Prodrug,Nafamostat

                          Therapeutic Area : Neurology

                          Highest Development Status : Phase I

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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