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TransCon PTH (palopegteriparatide) is an investigational prodrug designed to restore parathyroid hormone (PTH) to physiological levels over 24 hours in adult patients with hypoparathyroidism.
The trial achieved its primary endpoint of demonstrating non-inferiority in reducing HbA1c at week 52 with insulin icodec compared with once-daily basal insulin analogues.
Phase 3a ONWARDS 2 trial, demonstrated that 37% of adults with diabetes treated with insulin icodec achieved an HbA1c <7.0%, without experiencing severe or clinically significant hypoglycaemia, compared with 27% of those treated with insulin degludec at 26 weeks.
PTH replacement therapy with TransCon PTH (palopegteriparatide) was well-tolerated through Week 110, with continued normalization of mean urine calcium and no discontinuations from the trial due to adverse events.
TransCon PTH product candidate, treated patients reported significant reductions in disease-specific physical and cognitive symptoms and significant improvements in their quality of life.
People treated with CagriSema (semaglutide) achieved a numerically higher body weight reduction of 15.6% compared to a reduction of 5.1% for people treated with semaglutide and 8.1% with cagrilintide alone.
ONWARDS 6 is a 52-week trial comparing once-weekly insulin icodec with once-daily insulin degludec, both in combination with mealtime insulin. The objective of the trial is to assess the efficacy and safety of insulin icodec in 583 people with type 1 diabetes.
TransCon PTH (palopegteriparatide) was generally well-tolerated with no discontinuations related to study drug, and TransCon PTH-treated patients showed a mean decrease in 24-hour urine calcium excretion into the normal range.
From an overall baseline HbA1c of 8.5% once-weekly insulin icodec achieved a superior reduction in estimated HbA1c of -1.55% compared to -1.35% for insulin glargine (estimated treatment difference: -0.19%).
The net proceeds from the Private Placement are expected to be used to strengthen Zealand’s ability to execute on the refocused strategy prioritizing R&D and entering partnerships for commercial and late-stage development products.
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