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    [{"orgOrder":0,"company":"Histogen","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Infections and Infectious Diseases","country":"U.S.A","productType":"Other Small Molecule","year":"2021","type":"Inapplicable","leadProduct":"Emricasan","moa":"||Caspase","graph1":"Infections and Infectious Diseases","graph2":"Phase I","graph3":"Histogen","amount2":0,"highestDevelopmentShortName":"Ph I","therapeuticAreaShortName":"Infectious Diseases","amount2New":0,"dosageForm":"Oral Capsule","sponsorNew":"Histogen \/ Inapplicable","highestDevelopmentStatusID":"6","companyTruncated":"Histogen \/ Inapplicable"},{"orgOrder":0,"company":"Amerimmune","sponsor":"Histogen","pharmaFlowCategory":"D","therapeuticArea":"Infections and Infectious Diseases","country":"U.S.A","productType":"Other Small Molecule","year":"2020","type":"Collaboration","leadProduct":"Emricasan","moa":"||Caspase","graph1":"Infections and Infectious Diseases","graph2":"IND Enabling","graph3":"Amerimmune","amount2":0,"highestDevelopmentShortName":"IND","therapeuticAreaShortName":"Infectious Diseases","amount2New":0,"dosageForm":"Oral","sponsorNew":"Amerimmune \/ Histogen","highestDevelopmentStatusID":"5","companyTruncated":"Amerimmune \/ Histogen"},{"orgOrder":0,"company":"Histogen","sponsor":"Johns Hopkins University","pharmaFlowCategory":"D","therapeuticArea":"Infections and Infectious Diseases","country":"U.S.A","productType":"Other Small Molecule","year":"2023","type":"Licensing Agreement","leadProduct":"Emricasan","moa":"||Caspase","graph1":"Infections and Infectious Diseases","graph2":"Preclinical","graph3":"Histogen","amount2":0,"highestDevelopmentShortName":"Preclinical","therapeuticAreaShortName":"Infectious Diseases","amount2New":0,"dosageForm":"Oral","sponsorNew":"Histogen \/ Johns Hopkins University","highestDevelopmentStatusID":"4","companyTruncated":"Histogen \/ Johns Hopkins University"}]

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                            01

                            Histogen

                            U.S.A arrow
                            EPSC
                            Not Confirmed

                            Histogen

                            U.S.A arrow
                            EPSC
                            Not Confirmed
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                            Lead Product(s) : Emricasan,Inapplicable

                            Therapeutic Area : Infections and Infectious Diseases

                            Study Phase : Preclinical

                            Sponsor : Johns Hopkins University

                            Deal Size : Undisclosed

                            Deal Type : Licensing Agreement

                            DEALS_DEV arrow-down

                            Histogen Announces Exclusive Intellectual Property License Agreement with Johns Hopkins University

                            Details : Under the agreement, the intellectual property covers the use of emricasan, an orally available pan-caspase inhibitor designed to reduce the activities of human caspases, for the treatment of disease in humans resulting from viral or bacterial infections...

                            Product Name : Undisclosed

                            Product Type : Other Small Molecule

                            Upfront Cash : Undisclosed

                            March 04, 2023

                            Lead Product(s) : Emricasan,Inapplicable

                            Therapeutic Area : Infections and Infectious Diseases

                            Highest Development Status : Preclinical

                            Sponsor : Johns Hopkins University

                            Deal Size : Undisclosed

                            Deal Type : Licensing Agreement

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                            02

                            Histogen

                            U.S.A arrow
                            EPSC
                            Not Confirmed

                            Histogen

                            U.S.A arrow
                            EPSC
                            Not Confirmed
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                            Lead Product(s) : Emricasan,Inapplicable

                            Therapeutic Area : Infections and Infectious Diseases

                            Study Phase : Phase I

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Safety and Tolerability of Emricasan in Symptomatic Outpatients Diagnosed With Mild-COVID-19

                            Details : Undisclosed

                            Product Name : Undisclosed

                            Product Type : Other Small Molecule

                            Upfront Cash : Inapplicable

                            March 17, 2021

                            Lead Product(s) : Emricasan,Inapplicable

                            Therapeutic Area : Infections and Infectious Diseases

                            Highest Development Status : Phase I

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            03

                            Amerimmune

                            U.S.A arrow
                            EPSC
                            Not Confirmed

                            Amerimmune

                            U.S.A arrow
                            EPSC
                            Not Confirmed
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                            Lead Product(s) : Emricasan,Inapplicable

                            Therapeutic Area : Infections and Infectious Diseases

                            Study Phase : IND Enabling

                            Sponsor : Histogen

                            Deal Size : Undisclosed

                            Deal Type : Collaboration

                            DEALS_DEV arrow-down

                            Histogen and Amerimmune Enter into a Collaborative Development and Commercialization Agreement for Emricasan i...

                            Details : Histogen will retain ownership and oversight over emricasan and responsibility for all regulatory filings and maintaining its existing caspase inhibitor patent portfolio. Amerimmune will lead development efforts of emricasan in a phase 1 study in mild-CO...

                            Product Name : Undisclosed

                            Product Type : Other Small Molecule

                            Upfront Cash : Undisclosed

                            October 27, 2020

                            Lead Product(s) : Emricasan,Inapplicable

                            Therapeutic Area : Infections and Infectious Diseases

                            Highest Development Status : IND Enabling

                            Sponsor : Histogen

                            Deal Size : Undisclosed

                            Deal Type : Collaboration

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                            04

                            Meridian Bioscience

                            U.S.A arrow
                            EPSC
                            Not Confirmed

                            Meridian Bioscience

                            U.S.A arrow
                            EPSC
                            Not Confirmed
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                            Lead Product(s) : Emricasan,Inapplicable

                            Therapeutic Area : Hepatology (Liver, Pancreatic, Gall Bladder)

                            Study Phase : Undisclosed

                            Sponsor : Conatus Pharmaceuticals

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Companion Protocol for Methacetin Breath Test (MBT) in Conatus Protocol IDN-6556-17

                            Details : Undisclosed

                            Product Name : Undisclosed

                            Product Type : Other Small Molecule

                            Upfront Cash : Inapplicable

                            March 12, 2018

                            Lead Product(s) : Emricasan,Inapplicable

                            Therapeutic Area : Hepatology (Liver, Pancreatic, Gall Bladder)

                            Highest Development Status : Undisclosed

                            Sponsor : Conatus Pharmaceuticals

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            05

                            Meridian Bioscience

                            U.S.A arrow
                            EPSC
                            Not Confirmed

                            Meridian Bioscience

                            U.S.A arrow
                            EPSC
                            Not Confirmed
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                            Lead Product(s) : Emricasan,Inapplicable

                            Therapeutic Area : Hepatology (Liver, Pancreatic, Gall Bladder)

                            Study Phase : Undisclosed

                            Sponsor : Conatus Pharmaceuticals

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Companion Protocol for Methacetin Breath Test (MBT) in Conatus Protocol IDN-6556-14

                            Details : Undisclosed

                            Product Name : Undisclosed

                            Product Type : Other Small Molecule

                            Upfront Cash : Inapplicable

                            February 20, 2018

                            Lead Product(s) : Emricasan,Inapplicable

                            Therapeutic Area : Hepatology (Liver, Pancreatic, Gall Bladder)

                            Highest Development Status : Undisclosed

                            Sponsor : Conatus Pharmaceuticals

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            06

                            Conatus Pharmaceuticals

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                            EPSC
                            Not Confirmed

                            Conatus Pharmaceuticals

                            Country arrow
                            EPSC
                            Not Confirmed
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                            Lead Product(s) : Emricasan,Inapplicable

                            Therapeutic Area : Hepatology (Liver, Pancreatic, Gall Bladder)

                            Study Phase : Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Emricasan, a Caspase Inhibitor, for Treatment of Subjects With Decompensated NASH Cirrhosis

                            Details : Undisclosed

                            Product Name : Undisclosed

                            Product Type : Other Small Molecule

                            Upfront Cash : Inapplicable

                            July 02, 2017

                            Lead Product(s) : Emricasan,Inapplicable

                            Therapeutic Area : Hepatology (Liver, Pancreatic, Gall Bladder)

                            Highest Development Status : Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            07

                            Histogen

                            U.S.A arrow
                            EPSC
                            Not Confirmed

                            Histogen

                            U.S.A arrow
                            EPSC
                            Not Confirmed
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                            • EDQM
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                            Lead Product(s) : Emricasan,Inapplicable

                            Therapeutic Area : Trauma (Emergency, Injury, Surgery)

                            Study Phase : Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Emricasan, an Oral Caspase Inhibitor, in Subjects With NASH Cirrhosis and Severe Portal Hypertension

                            Details : Undisclosed

                            Product Name : Undisclosed

                            Product Type : Other Small Molecule

                            Upfront Cash : Inapplicable

                            November 09, 2016

                            Lead Product(s) : Emricasan,Inapplicable

                            Therapeutic Area : Trauma (Emergency, Injury, Surgery)

                            Highest Development Status : Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            08

                            Conatus Pharmaceuticals

                            Country arrow
                            EPSC
                            Not Confirmed

                            Conatus Pharmaceuticals

                            Country arrow
                            EPSC
                            Not Confirmed
                            • fda
                            • EDQM
                            • WHO-GMP
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                            Lead Product(s) : Emricasan,Inapplicable

                            Therapeutic Area : Hepatology (Liver, Pancreatic, Gall Bladder)

                            Study Phase : Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Emricasan, a Caspase Inhibitor, for Evaluation in Subjects With Non-Alcoholic Steatohepatitis (NASH) Fibrosis

                            Details : Undisclosed

                            Product Name : Undisclosed

                            Product Type : Other Small Molecule

                            Upfront Cash : Inapplicable

                            February 19, 2016

                            Lead Product(s) : Emricasan,Inapplicable

                            Therapeutic Area : Hepatology (Liver, Pancreatic, Gall Bladder)

                            Highest Development Status : Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            09

                            Conatus Pharmaceuticals

                            Country arrow
                            EPSC
                            Not Confirmed

                            Conatus Pharmaceuticals

                            Country arrow
                            EPSC
                            Not Confirmed
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                            • EDQM
                            • WHO-GMP
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                            Lead Product(s) : Emricasan,Inapplicable

                            Therapeutic Area : Hepatology (Liver, Pancreatic, Gall Bladder)

                            Study Phase : Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            A Study of IDN-6556 in Subjects With Liver Cirrhosis

                            Details : Undisclosed

                            Product Name : Undisclosed

                            Product Type : Other Small Molecule

                            Upfront Cash : Inapplicable

                            September 03, 2014

                            Lead Product(s) : Emricasan,Inapplicable

                            Therapeutic Area : Hepatology (Liver, Pancreatic, Gall Bladder)

                            Highest Development Status : Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            10

                            Conatus Pharmaceuticals

                            Country arrow
                            EPSC
                            Not Confirmed

                            Conatus Pharmaceuticals

                            Country arrow
                            EPSC
                            Not Confirmed
                            • fda
                            • EDQM
                            • WHO-GMP
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                            Lead Product(s) : Emricasan,Inapplicable

                            Therapeutic Area : Hepatology (Liver, Pancreatic, Gall Bladder)

                            Study Phase : Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            A Study of IDN-6556 in Cirrhotic Subjects With Portal Hypertension

                            Details : Undisclosed

                            Product Name : Undisclosed

                            Product Type : Other Small Molecule

                            Upfront Cash : Inapplicable

                            September 03, 2014

                            Lead Product(s) : Emricasan,Inapplicable

                            Therapeutic Area : Hepatology (Liver, Pancreatic, Gall Bladder)

                            Highest Development Status : Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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