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Finance"},{"orgOrder":0,"company":"Provepharm Life Solutions","sponsor":"A.forall","pharmaFlowCategory":"D","therapeuticArea":"Neurology","country":"FRANCE","productType":"Miscellaneous","year":"2025","type":"Acquisition","leadProduct":"Dihydroergotamine Mesylate","moa":"Serotonin 1d (5-HT1d) receptor","graph1":"Neurology","graph2":"Approved FDF","graph3":"Provepharm Life Solutions","amount2":0,"highestDevelopmentShortName":"Approved FDF","therapeuticAreaShortName":"Neurology","amount2New":0,"dosageForm":"Spray","sponsorNew":"Provepharm Life Solutions \/ A.forall","highestDevelopmentStatusID":"15","companyTruncated":"Provepharm Life Solutions \/ A.forall"}]

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                          01

                          The MedTech Conference
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                          The MedTech Conference
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                          Details : With the acquisition, A.forall considerably extends its marketed portfolio in the US, including Dihydroergotamine Mesylate, for the treatment of migraine and cluster headaches.

                          Product Name : Dihydroergotamine Mesylate-Generic

                          Product Type : Miscellaneous

                          Upfront Cash : Undisclosed

                          September 09, 2025

                          Lead Product(s) : Dihydroergotamine Mesylate

                          Therapeutic Area : Neurology

                          Highest Development Status : Approved FDF

                          Sponsor : A.forall

                          Deal Size : Undisclosed

                          Deal Type : Acquisition

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                          02

                          The MedTech Conference
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                          The MedTech Conference
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                          Details : Brekiya (dihydroergotamine mesylate) is the first and only dihydroergotamine (DHE) autoinjector for acute treatment of migraine with/without aura & acute treatment of cluster headaches in adults.

                          Product Name : Brekiya

                          Product Type : Miscellaneous

                          Upfront Cash : Inapplicable

                          May 15, 2025

                          Lead Product(s) : Dihydroergotamine Mesylate

                          Therapeutic Area : Neurology

                          Highest Development Status : Approved FDF

                          Sponsor : Undisclosed

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          03

                          The MedTech Conference
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                          The MedTech Conference
                          Not Confirmed

                          Details : Atzumi (dihydroergotamine mesylate) binds with high affinity to 5-HT1Dα and 5-HT1Dβ receptors. It is approved for acute treatment of migraine with or without aura in adults.

                          Product Name : Atzumi

                          Product Type : Miscellaneous

                          Upfront Cash : Inapplicable

                          April 30, 2025

                          Lead Product(s) : Dihydroergotamine Mesylate

                          Therapeutic Area : Neurology

                          Highest Development Status : Approved FDF

                          Sponsor : Undisclosed

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          04

                          The MedTech Conference
                          Not Confirmed
                          The MedTech Conference
                          Not Confirmed

                          Details : STS101 (dihydroergotamine nasal powder). STS101 is an investigational product which is being evaluated for migraine with or without aura in adults.

                          Product Name : Undisclosed

                          Product Type : Miscellaneous

                          Upfront Cash : Inapplicable

                          November 26, 2024

                          Lead Product(s) : Dihydroergotamine Mesylate

                          Therapeutic Area : Neurology

                          Highest Development Status : Phase III

                          Sponsor : Undisclosed

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          05

                          The MedTech Conference
                          Not Confirmed
                          The MedTech Conference
                          Not Confirmed

                          Details : STS101 (dihydroergotamine nasal powder). STS101 is an investigational product which is being evaluated for migraine with or without aura in adults.

                          Product Name : Undisclosed

                          Product Type : Miscellaneous

                          Upfront Cash : Inapplicable

                          October 30, 2024

                          Lead Product(s) : Dihydroergotamine Mesylate

                          Therapeutic Area : Neurology

                          Highest Development Status : Phase III

                          Sponsor : Undisclosed

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          06

                          The MedTech Conference
                          Not Confirmed
                          The MedTech Conference
                          Not Confirmed

                          Details : MannKind will grant Pulmatrix a royalty free, exclusive license to use MannKind's Cricket inhalation device for the inhaled delivery of PUR3100, a proprietary formulation of dihydroergotamine.

                          Product Name : Undisclosed

                          Product Type : Miscellaneous

                          Upfront Cash : Undisclosed

                          May 30, 2024

                          Lead Product(s) : Dihydroergotamine Mesylate

                          Therapeutic Area : Neurology

                          Highest Development Status : Phase I

                          Sponsor : Pulmatrix

                          Deal Size : Undisclosed

                          Deal Type : Licensing Agreement

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                          07

                          The MedTech Conference
                          Not Confirmed
                          The MedTech Conference
                          Not Confirmed

                          Details : STS101 (dihydroergotamine nasal powder). STS101 is an investigational product which is being evaluated in phase 1 clinical trials for the acute treatment of migraine with or without aura in adults.

                          Product Name : Undisclosed

                          Product Type : Miscellaneous

                          Upfront Cash : Inapplicable

                          January 18, 2024

                          Lead Product(s) : Dihydroergotamine Mesylate

                          Therapeutic Area : Neurology

                          Highest Development Status : Phase I

                          Sponsor : Undisclosed

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          08

                          The MedTech Conference
                          Not Confirmed
                          The MedTech Conference
                          Not Confirmed

                          Details : PUR3100 is an orally inhaled formulation of dihydroergotamine (DHE) engineered with iSPERSE™ technology, which is investigated for the treatment of acute migraine.

                          Product Name : Undisclosed

                          Product Type : Miscellaneous

                          Upfront Cash : Inapplicable

                          September 19, 2023

                          Lead Product(s) : Dihydroergotamine Mesylate

                          Therapeutic Area : Neurology

                          Highest Development Status : Phase I

                          Sponsor : Undisclosed

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          09

                          The MedTech Conference
                          Not Confirmed
                          The MedTech Conference
                          Not Confirmed

                          Details : PUR3100 dry powder inhaler is under development as an orally inhaled dihydroergotamine (DHE) engineered with iSPERSE™ for the acute treatment of migraine.

                          Product Name : Undisclosed

                          Product Type : Miscellaneous

                          Upfront Cash : Inapplicable

                          July 11, 2023

                          Lead Product(s) : Dihydroergotamine Mesylate

                          Therapeutic Area : Neurology

                          Highest Development Status : Phase I

                          Sponsor : Undisclosed

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          10

                          The MedTech Conference
                          Not Confirmed
                          The MedTech Conference
                          Not Confirmed

                          Details : STS101 (dihydroergotamine mesylate) constricts the pain-producing intracranial extracerebral blood vessels at the 5-HT1B receptors and inhibiting the trigeminal neurotransmission at the peripheral and central 5-HT1D receptors.

                          Product Name : Undisclosed

                          Product Type : Miscellaneous

                          Upfront Cash : Inapplicable

                          May 18, 2023

                          Lead Product(s) : Dihydroergotamine Mesylate

                          Therapeutic Area : Neurology

                          Highest Development Status : Phase III

                          Sponsor : Undisclosed

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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