Year
DEALS // DEV.
Country
Therapeutic Area
Study Phase
Deal Type
Product Type
Dosage Form
Lead Product
Target
Lead Product(s) : DNTH103
Therapeutic Area : Immunology
Study Phase : Phase II
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Dianthus Completes Enrollment in DNTH103 Phase 2 MaGic Trial for MG
Details : DNTH103 is an investigational, potent mAb selectively target the classical pathway by inhibiting only the active form of the C1s protein, for treating myasthenia gravis.
Product Name : DNTH103
Product Type : Antibody
Upfront Cash : Inapplicable
May 05, 2025
Lead Product(s) : DNTH103
Therapeutic Area : Immunology
Highest Development Status : Phase II
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Dianthus Therapeutics Gets FDA Clearance for Phase 2 Trial of DNTH103 in MMN
Details : DNTH103 is a potent monoclonal antibody engineered to selectively inhibitis only the active form of the C1s protein. It is being evaluated for the treatment of Multifocal Motor Neuropathy.
Product Name : DNTH103
Product Type : Antibody
Upfront Cash : Inapplicable
December 06, 2024
Lead Product(s) : DNTH103
Therapeutic Area : Immunology
Study Phase : Phase II
Sponsor : Hesperos
Deal Size : Inapplicable
Deal Type : Inapplicable
Hesperos Supports Investigational Product for Phase II Trial with Human-on-a-Chip®
Details : DNTH103 is an investigational, potent mAb engineered to selectively targets by inhibiting only the active form of the C1s protein. It is being evaluated for generalized myasthenia gravis.
Product Name : DNTH103
Product Type : Antibody
Upfront Cash : Inapplicable
September 24, 2024
Lead Product(s) : DNTH103
Therapeutic Area : Immunology
Highest Development Status : Phase II
Sponsor : Hesperos
Deal Size : Inapplicable
Deal Type : Inapplicable
Lead Product(s) : DNTH103
Therapeutic Area : Immunology
Study Phase : Phase II
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Dianthus Initiates Phase 2 MaGic Trial Of DNTH103 in Myasthenia Gravis
Details : DNTH103 is an investigational, clinical-stage monoclonal antibody targeting the classical pathway by inhibiting the active form of C1s protein, evaluated for generalized myasthenia gravis.
Product Name : DNTH103
Product Type : Antibody
Upfront Cash : Inapplicable
February 26, 2024
Lead Product(s) : DNTH103
Therapeutic Area : Immunology
Highest Development Status : Phase II
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Lead Product(s) : DNTH103
Therapeutic Area : Immunology
Study Phase : Phase I
Sponsor : Jefferies
Deal Size : $230.0 million
Deal Type : Private Placement
Dianthus Therapeutics Announces $230 Million Private Placement
Details : The net proceeds will be used for the clinical development of DNTH103. It is a selective inhibitor of the active C1s protein for the treatment of neuromuscular & autoimmune disorders.
Product Name : DNTH103
Product Type : Antibody
Upfront Cash : Undisclosed
January 22, 2024
Lead Product(s) : DNTH103
Therapeutic Area : Immunology
Highest Development Status : Phase I
Sponsor : Jefferies
Deal Size : $230.0 million
Deal Type : Private Placement
Lead Product(s) : DNTH103
Therapeutic Area : Immunology
Study Phase : Phase I
Sponsor : Fidelity Management & Research Company
Deal Size : $70.0 million
Deal Type : Private Placement
Magenta Therapeutics and Dianthus Therapeutics Announce Merger Agreement
Details : The net financing will be used to fund DNTH103 through multiple clinical data catalysts including Phase 1 in healthy volunteers, and Phase 2 trials in generalized Myasthenia Gravis and other indications.
Product Name : DNTH103
Product Type : Antibody
Upfront Cash : Undisclosed
March 05, 2023
Lead Product(s) : DNTH103
Therapeutic Area : Immunology
Highest Development Status : Phase I
Sponsor : Fidelity Management & Research Company
Deal Size : $70.0 million
Deal Type : Private Placement
Lead Product(s) : DNTH103
Therapeutic Area : Immunology
Study Phase : Phase I
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Details : DNTH103 is a next-generation monoclonal antibody that selectively targets only the active form of the C1s protein in the classical complement pathway. DNTH103 is designed as an infrequent and convenient subcutaneous injection.
Product Name : DNTH103
Product Type : Antibody
Upfront Cash : Inapplicable
November 30, 2022
Lead Product(s) : DNTH103
Therapeutic Area : Immunology
Highest Development Status : Phase I
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable