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                          Top Deals by Deal Size (USD bn)

                          01

                          PEGS Boston Summit
                          Not Confirmed
                          PEGS Boston Summit
                          Not Confirmed

                          Details : DNTH103 is an investigational, potent mAb selectively target the classical pathway by inhibiting only the active form of the C1s protein, for treating myasthenia gravis.

                          Product Name : DNTH103

                          Product Type : Antibody

                          Upfront Cash : Inapplicable

                          May 05, 2025

                          Lead Product(s) : DNTH103

                          Therapeutic Area : Immunology

                          Highest Development Status : Phase II

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          02

                          PEGS Boston Summit
                          Not Confirmed
                          PEGS Boston Summit
                          Not Confirmed

                          Details : DNTH103 is a potent monoclonal antibody engineered to selectively inhibitis only the active form of the C1s protein. It is being evaluated for the treatment of Multifocal Motor Neuropathy.

                          Product Name : DNTH103

                          Product Type : Antibody

                          Upfront Cash : Inapplicable

                          December 06, 2024

                          Lead Product(s) : DNTH103

                          Therapeutic Area : Neurology

                          Highest Development Status : Phase I

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          03

                          PEGS Boston Summit
                          Not Confirmed
                          PEGS Boston Summit
                          Not Confirmed

                          Details : DNTH103 is an investigational, potent mAb engineered to selectively targets by inhibiting only the active form of the C1s protein. It is being evaluated for generalized myasthenia gravis.

                          Product Name : DNTH103

                          Product Type : Antibody

                          Upfront Cash : Inapplicable

                          September 24, 2024

                          Lead Product(s) : DNTH103

                          Therapeutic Area : Immunology

                          Highest Development Status : Phase II

                          Sponsor : Hesperos

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          04

                          PEGS Boston Summit
                          Not Confirmed
                          PEGS Boston Summit
                          Not Confirmed

                          Details : DNTH103 is an investigational, clinical-stage monoclonal antibody targeting the classical pathway by inhibiting the active form of C1s protein, evaluated for generalized myasthenia gravis.

                          Product Name : DNTH103

                          Product Type : Antibody

                          Upfront Cash : Inapplicable

                          February 26, 2024

                          Lead Product(s) : DNTH103

                          Therapeutic Area : Immunology

                          Highest Development Status : Phase II

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          05

                          PEGS Boston Summit
                          Not Confirmed
                          PEGS Boston Summit
                          Not Confirmed

                          Details : The net proceeds will be used for the clinical development of DNTH103. It is a selective inhibitor of the active C1s protein for the treatment of neuromuscular & autoimmune disorders.

                          Product Name : DNTH103

                          Product Type : Antibody

                          Upfront Cash : Undisclosed

                          January 22, 2024

                          Lead Product(s) : DNTH103

                          Therapeutic Area : Immunology

                          Highest Development Status : Phase I

                          Sponsor : Jefferies

                          Deal Size : $230.0 million

                          Deal Type : Private Placement

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                          06

                          PEGS Boston Summit
                          Not Confirmed
                          PEGS Boston Summit
                          Not Confirmed

                          Details : The net financing will be used to fund DNTH103 through multiple clinical data catalysts including Phase 1 in healthy volunteers, and Phase 2 trials in generalized Myasthenia Gravis and other indications.

                          Product Name : DNTH103

                          Product Type : Antibody

                          Upfront Cash : Undisclosed

                          March 05, 2023

                          Lead Product(s) : DNTH103

                          Therapeutic Area : Immunology

                          Highest Development Status : Phase I

                          Sponsor : Fidelity Management & Research Company

                          Deal Size : $70.0 million

                          Deal Type : Private Placement

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                          07

                          PEGS Boston Summit
                          Not Confirmed
                          PEGS Boston Summit
                          Not Confirmed

                          Details : DNTH103 is a next-generation monoclonal antibody that selectively targets only the active form of the C1s protein in the classical complement pathway. DNTH103 is designed as an infrequent and convenient subcutaneous injection.

                          Product Name : DNTH103

                          Product Type : Antibody

                          Upfront Cash : Inapplicable

                          November 30, 2022

                          Lead Product(s) : DNTH103

                          Therapeutic Area : Immunology

                          Highest Development Status : Phase I

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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