
Year
DEALS // DEV.
Country
Therapeutic Area
Study Phase
Deal Type
Product Type
Dosage Form
Lead Product
Target

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Lead Product(s) : DNTH212
Therapeutic Area : Immunology
Study Phase : IND Enabling
Recipient : Leads Biolabs
Deal Size : $1,000.0 million
Deal Type : Licensing Agreement
Dianthus Therapeutics Licenses DNTH212 for Severe Autoimmune Diseases from Leads Biolabs
Details : Through the licensing deal for DNTH212, undisclosed company aims to target APRIL/BAFF/BDCA2 in severe autoimmune diseases.
Product Name : DNTH212
Product Type : Protein
Upfront Cash : $30.0 million
October 16, 2025
Lead Product(s) : DNTH212
Therapeutic Area : Immunology
Highest Development Status : IND Enabling
Recipient : Leads Biolabs
Deal Size : $1,000.0 million
Deal Type : Licensing Agreement

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Lead Product(s) : Claseprubart
Therapeutic Area : Immunology
Study Phase : Phase II
Sponsor : Jefferies
Deal Size : $288.0 million
Deal Type : Public Offering
Dianthus Announces Closing of its Upsized $288 Million Underwritten Public Offering
Details : The net proceeds will be used to advance the Company’s preclinical and clinical development activities, including DNTH103 (claseprubart), an investigational, long-acting monoclonal antibody.
Product Name : Undisclosed
Product Type : Antibody, Unconjugated
Upfront Cash : Undisclosed
September 11, 2025
Lead Product(s) : Claseprubart
Therapeutic Area : Immunology
Highest Development Status : Phase II
Sponsor : Jefferies
Deal Size : $288.0 million
Deal Type : Public Offering

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Lead Product(s) : Claseprubart
Therapeutic Area : Immunology
Study Phase : Phase II
Sponsor : Jefferies
Deal Size : $150.0 million
Deal Type : Public Offering
Dianthus Therapeutics, Inc. Announces Proposed $150 Million Underwritten Public Offering
Details : The net proceeds will be used to advance the Company’s preclinical and clinical development activities, including DNTH103 (claseprubart), an investigational, long-acting monoclonal antibody.
Product Name : Undisclosed
Product Type : Antibody, Unconjugated
Upfront Cash : Undisclosed
September 08, 2025
Lead Product(s) : Claseprubart
Therapeutic Area : Immunology
Highest Development Status : Phase II
Sponsor : Jefferies
Deal Size : $150.0 million
Deal Type : Public Offering

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Lead Product(s) : DNTH103
Therapeutic Area : Immunology
Study Phase : Phase II
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable
Dianthus Completes Enrollment in DNTH103 Phase 2 MaGic Trial for MG
Details : DNTH103 is an investigational, potent mAb selectively target the classical pathway by inhibiting only the active form of the C1s protein, for treating myasthenia gravis.
Product Name : Undisclosed
Product Type : Antibody, Unconjugated
Upfront Cash : Inapplicable
May 05, 2025
Lead Product(s) : DNTH103
Therapeutic Area : Immunology
Highest Development Status : Phase II
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable

Details : DNTH103 is a Antibody drug candidate, which is currently being evaluated in phase III clinical studies for the treatment of Polyradiculoneuropathy, Chronic Inflammatory Demyelinating.
Product Name : Undisclosed
Product Type : Antibody, Unconjugated
Upfront Cash : Inapplicable
March 05, 2025

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Lead Product(s) : DNTH103
Therapeutic Area : Immunology
Study Phase : Phase II
Sponsor : Hesperos
Deal Size : Inapplicable
Deal Type : Inapplicable
Hesperos Supports Investigational Product for Phase II Trial with Human-on-a-Chip®
Details : DNTH103 is an investigational, potent mAb engineered to selectively targets by inhibiting only the active form of the C1s protein. It is being evaluated for generalized myasthenia gravis.
Product Name : Undisclosed
Product Type : Antibody, Unconjugated
Upfront Cash : Inapplicable
September 24, 2024
Lead Product(s) : DNTH103
Therapeutic Area : Immunology
Highest Development Status : Phase II
Sponsor : Hesperos
Deal Size : Inapplicable
Deal Type : Inapplicable

A Clinical Study to Evaluate DNTH103 in Adults With Multifocal Motor Neuropathy
Details : DNTH103 is a Antibody drug candidate, which is currently being evaluated in phase II clinical studies for the treatment of Polyneuropathies.
Product Name : Undisclosed
Product Type : Antibody, Unconjugated
Upfront Cash : Inapplicable
August 05, 2024

Dianthus Therapeutics Gets FDA Clearance for Phase 2 Trial of DNTH103 in MMN
Details : DNTH103 is a potent monoclonal antibody engineered to selectively inhibitis only the active form of the C1s protein. It is being evaluated for the treatment of Multifocal Motor Neuropathy.
Product Name : Undisclosed
Product Type : Antibody, Unconjugated
Upfront Cash : Inapplicable
June 12, 2024

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Lead Product(s) : DNTH103
Therapeutic Area : Immunology
Study Phase : Phase II
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable
A Phase 2 Study to Evaluate DNTH103 in Adults With Generalized Myasthenia Gravis (MAGIC)
Details : DNTH103 is a Antibody drug candidate, which is currently being evaluated in phase II clinical studies for the treatment of Myasthenia Gravis.
Product Name : Undisclosed
Product Type : Antibody, Unconjugated
Upfront Cash : Inapplicable
February 28, 2024
Lead Product(s) : DNTH103
Therapeutic Area : Immunology
Highest Development Status : Phase II
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable

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Lead Product(s) : DNTH103
Therapeutic Area : Immunology
Study Phase : Phase II
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable
Dianthus Initiates Phase 2 MaGic Trial Of DNTH103 in Myasthenia Gravis
Details : DNTH103 is an investigational, clinical-stage monoclonal antibody targeting the classical pathway by inhibiting the active form of C1s protein, evaluated for generalized myasthenia gravis.
Product Name : Undisclosed
Product Type : Antibody, Unconjugated
Upfront Cash : Inapplicable
February 26, 2024
Lead Product(s) : DNTH103
Therapeutic Area : Immunology
Highest Development Status : Phase II
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable
