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    [{"orgOrder":0,"company":"Concert Pharmaceuticals","sponsor":"Vertex","pharmaFlowCategory":"D","amount":"$250.0 million","upfrontCash":"$160.0 million","newsHeadline":"Concert Pharmaceuticals Announces Sale of VX-561 Milestones to Vertex for $32 Million","therapeuticArea":"Genetic Disease","highestDevelopmentStatus":"Phase II","country":"U.S.A","productType":"Small molecule","productStatus":"New Molecular Entity","date":"May 2021","url1":"","url2":"","graph1":"Genetic Disease","graph2":"Phase II"},{"orgOrder":0,"company":"Vertex Pharmaceuticals","sponsor":"Not Applicable","pharmaFlowCategory":"DU","amount":"Not Applicable","upfrontCash":"Not Applicable","newsHeadline":"Vertex Start Phase 3 Development Program for New Once-Daily Triple Combo Regimen","therapeuticArea":"Genetic Disease","highestDevelopmentStatus":"Phase II","country":"U.S.A","productType":"Small molecule","productStatus":"New Molecular Entity","date":"July 2021","url1":"","url2":"","graph1":"Genetic Disease","graph2":"Phase II"},{"orgOrder":0,"company":"Vertex Pharmaceuticals","sponsor":"Not Applicable","pharmaFlowCategory":"DU","amount":"Not Applicable","upfrontCash":"Not Applicable","newsHeadline":"Vertex Announces Positive Results From Pivotal Trials of Vanzacaftor\/Tezacaftor\/Deutivacaftor, Next-in-Class Triple Combination Treatment for Cystic Fibrosis","therapeuticArea":"Genetic Disease","highestDevelopmentStatus":"Phase III","country":"U.S.A","productType":"Small molecule","productStatus":"New Molecular Entity","date":"February 2024","url1":"","url2":"","graph1":"Genetic Disease","graph2":"Phase III"}]

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              Vertex Pharmaceuticals

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              Vertex Announces Positive Results From Pivotal Trials of Vanzacaftor/Tezacaftor/Deutivacaftor, Next-in-Class Triple Combination Treatment for Cystic Fibrosis

              Details:

              VX-121/VX-661/VX-561 (vanzacaftor/tezacaftor/deutivacaftor) is a combination of three CFTR modulators. It is being evaluated in phase 3 clinial trials for the treatment of Cystic Fibrosis.

              Lead Product(s): Vanzacaftor,Tezacaftor,Deutivacaftor

              Therapeutic Area: Genetic Disease Product Name: VX-121

              Highest Development Status: Phase III Product Type: Small molecule

              Partner/Sponsor/Collaborator: Not Applicable

              Deal Size: Not Applicable Upfront Cash: Not Applicable

              Deal Type: Not Applicable February 05, 2024

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              Vertex Pharmaceuticals

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              Vertex Start Phase 3 Development Program for New Once-Daily Triple Combo Regimen

              Details:

              The combination of VX-121/tezacaftor/VX-561 was first identified as having potential for increased efficacy based on its ability to drive higher levels of chloride transport compared to TRIKAFTA (elexacaftor/tezacaftor/ivacaftor /ivacaftor) in human bronchial epithelial cells.

              Lead Product(s): Vanzacaftor,Tezacaftor,Deutivacaftor

              Therapeutic Area: Genetic Disease Product Name: VX-121

              Highest Development Status: Phase II Product Type: Small molecule

              Partner/Sponsor/Collaborator: Not Applicable

              Deal Size: Not Applicable Upfront Cash: Not Applicable

              Deal Type: Not Applicable July 28, 2021

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              Concert Pharmaceuticals

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              Concert Pharmaceuticals Announces Sale of VX-561 Milestones to Vertex for $32 Million

              Details:

              VX-561 is an investigational cystic fibrosis transmembrane conductance regulator (CFTR) potentiator that has the potential to be used as part of future once-daily combination regimens of CFTR modulators that treat the underlying cause of cystic fibrosis.

              Lead Product(s): Deutivacaftor

              Therapeutic Area: Genetic Disease Product Name: VX-561

              Highest Development Status: Phase II Product Type: Small molecule

              Partner/Sponsor/Collaborator: Vertex

              Deal Size: $250.0 million Upfront Cash: $160.0 million

              Deal Type: Agreement May 17, 2021

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