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                          01

                          Indo Livestock Expo
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                          Indo Livestock Expo
                          Not Confirmed

                          Details : DB-007-4 has significant inhibitory effects in both disease score and itch. Currently being investigated for the treatment of atopic dermatitis.

                          Product Name : DB-007-5

                          Product Type : Other Small Molecule

                          Upfront Cash : Inapplicable

                          February 26, 2025

                          Lead Product(s) : DB-007-5

                          Therapeutic Area : Dermatology

                          Highest Development Status : Preclinical

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          02

                          Indo Livestock Expo
                          Not Confirmed
                          Indo Livestock Expo
                          Not Confirmed

                          Details : AbbVie acquires Nimble, including its lead asset, an investigational oral peptide IL23R inhibitor in preclinical development for the treatment of psoriasis.

                          Product Name : Undisclosed

                          Product Type : Peptide

                          Upfront Cash : $200.0 million

                          January 23, 2025

                          Lead Product(s) : Undisclosed

                          Therapeutic Area : Dermatology

                          Highest Development Status : Preclinical

                          Sponsor : AbbVie Inc

                          Deal Size : $200.0 million

                          Deal Type : Acquisition

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                          03

                          Indo Livestock Expo
                          Not Confirmed
                          Indo Livestock Expo
                          Not Confirmed

                          Details : The financing is intended to support the clinical development of CYPS317, currently being evaluated for the treatment of psoriasis.

                          Product Name : CYPS317

                          Product Type : Cell and Gene therapy

                          Upfront Cash : Undisclosed

                          December 23, 2024

                          Lead Product(s) : CYPS317

                          Therapeutic Area : Dermatology

                          Highest Development Status : Preclinical

                          Sponsor : Yorkville

                          Deal Size : $25.0 million

                          Deal Type : Financing

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                          04

                          Indo Livestock Expo
                          Not Confirmed
                          Indo Livestock Expo
                          Not Confirmed

                          Details : AbbVie will acquire Nimble, including its lead asset, an investigational oral peptide IL23R inhibitor in preclinical development for the treatment of psoriasis.

                          Product Name : Undisclosed

                          Product Type : Peptide

                          Upfront Cash : $200.0 million

                          December 13, 2024

                          Lead Product(s) : Undisclosed

                          Therapeutic Area : Dermatology

                          Highest Development Status : Preclinical

                          Sponsor : AbbVie Inc

                          Deal Size : $200.0 million

                          Deal Type : Acquisition

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                          05

                          Indo Livestock Expo
                          Not Confirmed
                          Indo Livestock Expo
                          Not Confirmed

                          Details : ‘1104 (IRL201104) is a first-in-class immune-resetting peptide. Its subcutaneos formulation is currently being evaluated for the treatment of patients with atopic dermatitis.

                          Product Name : ‘1104

                          Product Type : Peptide

                          Upfront Cash : Inapplicable

                          December 12, 2024

                          Lead Product(s) : IRL201104

                          Therapeutic Area : Dermatology

                          Highest Development Status : Preclinical

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          06

                          Indo Livestock Expo
                          Not Confirmed
                          Indo Livestock Expo
                          Not Confirmed

                          Details : Alys will use the net proceeds to advance Immuno-Dermatology focused pipeline, including its siRNA lipid conjugate therapy for the treatment of atopic dermatitis.

                          Product Name : Undisclosed

                          Product Type : Undisclosed

                          Upfront Cash : Undisclosed

                          December 02, 2024

                          Lead Product(s) : Undisclosed

                          Therapeutic Area : Dermatology

                          Highest Development Status : Preclinical

                          Sponsor : Medicxi

                          Deal Size : $100.0 million

                          Deal Type : Financing

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                          07

                          Indo Livestock Expo
                          Not Confirmed
                          Indo Livestock Expo
                          Not Confirmed

                          Details : PN-881, a potential best-in-class oral peptide interleukin-17 (IL-17) antagonist, as a development candidate for the treatment of immune-mediated skin diseases.

                          Product Name : PN-881

                          Product Type : Peptide

                          Upfront Cash : Inapplicable

                          November 21, 2024

                          Lead Product(s) : PN-881

                          Therapeutic Area : Dermatology

                          Highest Development Status : Preclinical

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          08

                          Indo Livestock Expo
                          Not Confirmed
                          Indo Livestock Expo
                          Not Confirmed

                          Details : The net proceeds will support Derm-Biome’s preclinical research activities for DB-007-4, a potential best-in-class, first line topical treatment focusing on inflammatory diseases and healthy aging.

                          Product Name : DB-007-4

                          Product Type : Other Small Molecule

                          Upfront Cash : Undisclosed

                          August 05, 2024

                          Lead Product(s) : DB-007-4

                          Therapeutic Area : Dermatology

                          Highest Development Status : Preclinical

                          Sponsor : Natural Sciences and Engineering Council

                          Deal Size : $0.4 million

                          Deal Type : Funding

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                          09

                          Indo Livestock Expo
                          Not Confirmed
                          Indo Livestock Expo
                          Not Confirmed

                          Details : The new funding will support further development of Enveda’s breakthrough platform, including Enveda's lead program for atopic dermatitis, a novel oral first-in-class anti-inflammatory agent.

                          Product Name : Undisclosed

                          Product Type : Undisclosed

                          Upfront Cash : Undisclosed

                          June 14, 2024

                          Lead Product(s) : Undisclosed

                          Therapeutic Area : Dermatology

                          Highest Development Status : Preclinical

                          Sponsor : Premji Invest

                          Deal Size : $119.0 million

                          Deal Type : Series B Financing

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                          10

                          Indo Livestock Expo
                          Not Confirmed
                          Indo Livestock Expo
                          Not Confirmed

                          Details : Stemson is developing an iPSC-derived autologous therapy for regenerating hair follicles, under evaluation for various types of alopecia.

                          Product Name : Undisclosed

                          Product Type : Undisclosed

                          Upfront Cash : Inapplicable

                          June 02, 2024

                          Lead Product(s) : Undisclosed

                          Therapeutic Area : Dermatology

                          Highest Development Status : Preclinical

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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