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Find Novel Dermatology Drugs in Preclinical Development in UNITED STATES

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            Lead Product(s): HT-001

            Therapeutic Area: Dermatology Product Name: HT-001

            Highest Development Status: Preclinical Product Type: Undisclosed

            Partner/Sponsor/Collaborator: Charles River Laboratories, Inc

            Deal Size: Undisclosed Upfront Cash: Undisclosed

            Deal Type: Collaboration January 11, 2021

            Details:

            Hoth Therapeutics has entered into an agreement with Charles River Laboratories to start preclinical studies of HT-001, a topical formulation designed for the treatment of patients with rash and skin disorders associated with initial and repeat EGFR inhibitor cancer treatment.

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            Lead Product(s): Undisclosed

            Therapeutic Area: Dermatology Product Name: Undisclosed

            Highest Development Status: Preclinical Product Type: Small molecule

            Partner/Sponsor/Collaborator: RA Capital Management

            Deal Size: $80.0 million Upfront Cash: Undisclosed

            Deal Type: Series C Financing January 08, 2021

            Details:

            Financing proceeds will support the progression of the Company’s first-in-class, oral IL-17 antagonist into clinical trials and advancement of its PPI antagonist pipeline.

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            Lead Product(s): Undisclosed

            Therapeutic Area: Dermatology Product Name: Undisclosed

            Highest Development Status: Preclinical Product Type: Small molecule

            Partner/Sponsor/Collaborator: Evommune

            Deal Size: Undisclosed Upfront Cash: Undisclosed

            Deal Type: Licensing Agreement January 07, 2021

            Details:

            Agreement aims to develop and commercialize three development programs for the treatment of various inflammatory diseases which include IRAK4/TrkA; RORγt; and MRGPRX2.

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            Lead Product(s): HT-001

            Therapeutic Area: Dermatology Product Name: HT-001

            Highest Development Status: Preclinical Product Type: Undisclosed

            Partner/Sponsor/Collaborator: Not Applicable

            Deal Size: Not Applicable Upfront Cash: Not Applicable

            Deal Type: Not Applicable December 23, 2020

            Details:

            HT-001 is targeted to treat these EGFR-induced skin disorders to allow patients to achieve the best potential outcomes of EGFR therapy, as there are currently no approved drugs to specifically treat EGFR inhibitor-induced skin disorders.

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            Lead Product(s): ATR-01

            Therapeutic Area: Dermatology Product Name: ATR-01

            Highest Development Status: Preclinical Product Type: Large molecule

            Partner/Sponsor/Collaborator: Leaps by Bayer

            Deal Size: $17.0 million Upfront Cash: Undisclosed

            Deal Type: Series B Financing October 15, 2020

            Details:

            The partnership will focus on developing cutting-edge skin products using engineered and wild-type bacteria for biotherapeutic, over-the-counter and cosmetic applications leveraging Azitra’s technology platform for both live therapeutic products and consumer programs.

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            Lead Product(s): Tapinarof

            Therapeutic Area: Dermatology Product Name: Undisclosed

            Highest Development Status: Preclinical Product Type: Small molecule

            Partner/Sponsor/Collaborator: Not Applicable

            Deal Size: Not Applicable Upfront Cash: Not Applicable

            Deal Type: Not Applicable October 06, 2020

            Details:

            Derm-Biome's topical drugs produced significant, and dose dependent inhibitory effects in a well established mouse model of psoriasis. The drug showed comparable inhibitory effects to tapinarof over a similar range of concentrations.

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            Lead Product(s): HT-003

            Therapeutic Area: Dermatology Product Name: HT-003

            Highest Development Status: Preclinical Product Type: Small molecule

            Partner/Sponsor/Collaborator: Not Applicable

            Deal Size: Not Applicable Upfront Cash: Not Applicable

            Deal Type: Not Applicable September 24, 2020

            Details:

            Initial data from the first phase of the research reports that one of the most critical genes for acne pathophysiology, toll-like receptor 2 (TLR2), is significantly inhibited by HT-003.

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            Lead Product(s): KB301

            Therapeutic Area: Dermatology Product Name: KB301

            Highest Development Status: Preclinical Product Type: Cell and Gene therapy

            Partner/Sponsor/Collaborator: Not Applicable

            Deal Size: Not Applicable Upfront Cash: Not Applicable

            Deal Type: Not Applicable August 25, 2020

            Details:

            KB301 is designed to restore collagen homeostasis locally via directed COL3A1 expression, thereby reconstructing an optimal physiologic environment in the skin to treat wrinkles and other superficial skin defects.

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            Lead Product(s): Antibiotic,Zinc chelator

            Therapeutic Area: Dermatology Product Name: BioLexa

            Highest Development Status: Preclinical Product Type: Small molecule

            Partner/Sponsor/Collaborator: Not Applicable

            Deal Size: Not Applicable Upfront Cash: Not Applicable

            Deal Type: Not Applicable August 13, 2020

            Details:

            Study to determine the safety, tolerability, pharmacokinetics and efficacy of twice daily application of topical BioLexa in healthy subjects and patients with mild to moderate atopic dermatitis.

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            Lead Product(s): VNLG 152

            Therapeutic Area: Dermatology Product Name: VNLG 152

            Highest Development Status: Preclinical Product Type: Small molecule

            Partner/Sponsor/Collaborator: Isoprene Pharmaceuticals

            Deal Size: Undisclosed Upfront Cash: Undisclosed

            Deal Type: Licensing Agreement July 31, 2020

            Details:

            Isoprene Pharmaceuticals will acquire rights to Hoth's VNLG-152, a novel retinamides (Retinoic acid metabolism blocking agents, or RAMBAs) for the treatment of dermatological diseases.