Lead Product(s) : NDI-034858
Therapeutic Area : Dermatology
Study Phase : Phase II
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Details : TAK-279 (NDI-034858) is a late-stage, highly selective, oral allosteric tyrosine kinase 2 (TYK2) inhibitor being evaluated for the treatment of multiple autoimmune diseases.
Product Name : TAK-279
Product Type : Other Small Molecule
Upfront Cash : Inapplicable
March 18, 2023
Lead Product(s) : NDI-034858
Therapeutic Area : Dermatology
Highest Development Status : Phase II
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Lead Product(s) : ME3183
Therapeutic Area : Dermatology
Study Phase : Phase II
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Details : In non-clinical studies, ME3183, a selective phosphodiesterase-4 (PDE4) inhibitor, showed greater anti-inflammatory effect and its inhibitory effect on TNF-α production was approximately 30-fold greater than the existing orally-available PDE4 inhibitor ...
Product Name : ME3183
Product Type : Other Small Molecule
Upfront Cash : Inapplicable
July 04, 2022
Lead Product(s) : ME3183
Therapeutic Area : Dermatology
Highest Development Status : Phase II
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Lead Product(s) : Dersimelagon
Therapeutic Area : Dermatology
Study Phase : Phase II
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Mitsubishi Initiates Phase 3 Clinical Trial for MT-7117
Details : The Phase-2 study was a randomized, double-blind, placebo-controlled study to assess the efficacy, safety, and tolerability of MT-7117 in subjects with diffuse cutaneous systemic sclerosis.
Product Name : MT-7117
Product Type : Other Small Molecule
Upfront Cash : Inapplicable
March 31, 2021
Lead Product(s) : Dersimelagon
Therapeutic Area : Dermatology
Highest Development Status : Phase II
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Lead Product(s) : Rocatinlimab
Therapeutic Area : Dermatology
Study Phase : Phase II
Sponsor : Amgen Inc
Deal Size : Inapplicable
Deal Type : Inapplicable
Details : KHK4083/AMG 451 is a potential first-in-class anti-OX40 fully human monoclonal antibody in development for the treatment of moderate-to-severe atopic dermatitis.
Product Name : KHK4083
Product Type : Antibody
Upfront Cash : Inapplicable
February 10, 2021
Lead Product(s) : Rocatinlimab
Therapeutic Area : Dermatology
Highest Development Status : Phase II
Sponsor : Amgen Inc
Deal Size : Inapplicable
Deal Type : Inapplicable
Lead Product(s) : Rocatinlimab
Therapeutic Area : Dermatology
Study Phase : Phase II
Sponsor : Amgen Inc
Deal Size : $1,250.0 million
Deal Type : Collaboration
Amgen and Kyowa Kirin to Jointly Develop and Commercialize KHK4083
Details : KHK4083 is an anti-OX40 fully human monoclonal antibody discovered by Kyowa Kirin and engineered with Kyowa Kirin’s patented POTELLIGENT® defucosylation technology to enhance its antibody-dependent cellular cytotoxicity (ADCC) activity.
Product Name : KHK4083
Product Type : Antibody
Upfront Cash : $400.0 million
January 06, 2021
Lead Product(s) : Rocatinlimab
Therapeutic Area : Dermatology
Highest Development Status : Phase II
Sponsor : Amgen Inc
Deal Size : $1,250.0 million
Deal Type : Collaboration