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    [{"orgOrder":0,"company":"Cynata Therapeutics","sponsor":"Not Applicable","pharmaFlowCategory":"DU","amount":"Not Applicable","upfrontCash":"Not Applicable","newsHeadline":"Cynata Therapeutics welcomes UK Regulatory Authority approval of Phase 2 clinical trial in critical limb ischaemia","therapeuticArea":"Cardiology\/Vascular Diseases","highestDevelopmentStatus":"Phase II","country":"AUSTRALIA","productType":"Cell and Gene therapy","productStatus":"New Molecular Entity","date":"January 2020","url1":"","url2":"","graph1":"Cardiology\/Vascular Diseases","graph2":"Phase II"},{"orgOrder":0,"company":"Cynata Therapeutics","sponsor":"Not Applicable","pharmaFlowCategory":"DU","amount":"Not Applicable","upfrontCash":"Not Applicable","newsHeadline":"Cynata Completes Phase 1 GvHD Clinical Trial Follow-up with Positive Results","therapeuticArea":"Immunology","highestDevelopmentStatus":"Phase I","country":"AUSTRALIA","productType":"Cell and Gene therapy","productStatus":"New Molecular 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Applicable","newsHeadline":"Cynata Therapeutics Completes Patient Enrolment in Phase 1 Trial of CYP-006TK in Diabetic Foot Ulcers","therapeuticArea":"Podiatry","highestDevelopmentStatus":"Phase I","country":"AUSTRALIA","productType":"Cell and Gene therapy","productStatus":"New Molecular Entity","date":"April 2024","url1":"","url2":"","graph1":"Podiatry","graph2":"Phase I"}]

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              Cynata Therapeutics

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              Cynata Therapeutics Completes Patient Enrolment in Phase 1 Trial of CYP-006TK in Diabetic Foot Ulcers

              Details:

              CYP-006TK is a topical wound dressing, cell and gene therapy drug candidate, which is currently being evaluated for the treatment of patients with diabetic foot ulcers.

              Lead Product(s): CYP-006TK

              Therapeutic Area: Podiatry Product Name: CYP-006TK

              Highest Development Status: Phase I Product Type: Cell and Gene therapy

              Partner/Sponsor/Collaborator: Not Applicable

              Deal Size: Not Applicable Upfront Cash: Not Applicable

              Deal Type: Not Applicable April 09, 2024

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              Cynata Therapeutics

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              First Patient Treated in Phase 2 GvHD Trial

              Details:

              CYP-001 is Cynata's Cymerus™ off-the-shelf iPSC[1]-derived MSC[2] product candidate for intravenous infusion, which is being evaluated for the treatment of acute graft versus host disease.

              Lead Product(s): CYP-001,Prednisone

              Therapeutic Area: Immunology Product Name: CYP-001

              Highest Development Status: Phase II Product Type: Cell and Gene therapy

              Partner/Sponsor/Collaborator: Not Applicable

              Deal Size: Not Applicable Upfront Cash: Not Applicable

              Deal Type: Not Applicable March 04, 2024

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              Cynata Therapeutics

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              Encouraging Initial Data from CYP-006TK Diabetic Foot Ulcer Clinical Trial

              Details:

              CYP-006TK is allogenic mesenchymoangioblast-derived mesenchymal stem cells (MCA-derived MSCs) or Cymerus™ MSCs, seeded onto a heptylamine plasma polymer-coated silicone dressing. It is being evaluated for the treatment of diabetic foot ulcer.

              Lead Product(s): CYP-006TK

              Therapeutic Area: Podiatry Product Name: CYP-006TK

              Highest Development Status: Phase I Product Type: Cell and Gene therapy

              Partner/Sponsor/Collaborator: Not Applicable

              Deal Size: Not Applicable Upfront Cash: Not Applicable

              Deal Type: Not Applicable February 26, 2024

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              Cynata Therapeutics

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              US FDA Clears IND for Cynata's Phase 2 Clinical Trial of CYP-001 in GvHD

              Details:

              CYP-001 (mesenchymoangioblast-derived mesenchymal stem cells) met all clinical endpoints and demonstrated positive safety and efficacy data for the treatment of steroid-resistant acute graft-versus-host disease (GvHD) in a Phase 1 trial.

              Lead Product(s): Mesenchymoangioblast-derived Mesenchymal Stem Cells

              Therapeutic Area: Immunology Product Name: CYP-001

              Highest Development Status: IND Enabling Product Type: Cell and Gene therapy

              Partner/Sponsor/Collaborator: Not Applicable

              Deal Size: Not Applicable Upfront Cash: Not Applicable

              Deal Type: Not Applicable May 26, 2022

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              Ethics Approval for Cynata’s Clinical Trial in Diabetic Foot Ulcers

              Details:

              This will be the first clinical trial to utilise CYP-006TK, a polymer-coated silicon dressing (seeded with Cymerus MSCs) that Cynata has licensed from TekCyte Pty Ltd (TekCyte).

              Lead Product(s): Cymerus mesenchymal stem cells

              Therapeutic Area: Podiatry Product Name: CYP-006TK

              Highest Development Status: Preclinical Product Type: Cell and Gene therapy

              Partner/Sponsor/Collaborator: Not Applicable

              Deal Size: Not Applicable Upfront Cash: Not Applicable

              Deal Type: Not Applicable June 30, 2021

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              Cynata Therapeutics

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              Cynata Expands MEND Clinical Trial in Covid-19 and Respiratory Failure

              Details:

              In the initial stage, the trial was designed to assess the early efficacy of Cymerus MSCs in Covid-19 patients admitted to intensive care. The trial will now analyse the early efficacy of Cymerus MSCs in patients with respiratory failure.

              Lead Product(s): CYP-001

              Therapeutic Area: Infections and Infectious Diseases Product Name: Cymerus MSCs

              Highest Development Status: Phase I/ Phase II Product Type: Cell and Gene therapy

              Partner/Sponsor/Collaborator: Not Applicable

              Deal Size: Not Applicable Upfront Cash: Not Applicable

              Deal Type: Not Applicable March 29, 2021

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              Cynata Therapeutics

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              New Preclinical Study to Investigate the High Potency of Cymerus™ MSCs

              Details:

              Clinical trials of Cymerus MSC products in osteoarthritis (Phase 3) and in severe complications arising from COVID-19 (Phase 2) are currently ongoing.

              Lead Product(s): Cymerus mesenchymal stem cell

              Therapeutic Area: Pulmonary/Respiratory Diseases Product Name: Undisclosed

              Highest Development Status: Preclinical Product Type: Cell and Gene therapy

              Partner/Sponsor/Collaborator: Not Applicable

              Deal Size: Not Applicable Upfront Cash: Not Applicable

              Deal Type: Not Applicable March 02, 2021

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              Cynata Therapeutics

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              Cynata Advances Planned Clinical Trial in Diabetic Foot Ulcers in MoU With TekCyte

              Details:

              Cynata plans to undertake a clinical trial of its Cymerus MSC product in patients with diabetic foot ulcers based on this solid pre-clinical foundation and utilising the TekCyte technology.

              Lead Product(s): Cymerus mesenchymal stem cell

              Therapeutic Area: Podiatry Product Name: Undisclosed

              Highest Development Status: Preclinical Product Type: Cell and Gene therapy

              Partner/Sponsor/Collaborator: Not Applicable

              Deal Size: Not Applicable Upfront Cash: Not Applicable

              Deal Type: Not Applicable March 01, 2021

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              Cynata Therapeutics

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              Cymerus MSCs Demonstrate Efficacy in Preclinical Lung Disease Study

              Details:

              Treatment with Cynata’s Cymerus MSCs led to statistically significant improvements in multiple harmful effects of IPF, including interstitial fibrosis, dynamic lung compliance and airway resistance.

              Lead Product(s): Cymerus mesenchymal stem cells

              Therapeutic Area: Pulmonary/Respiratory Diseases Product Name: Undisclosed

              Highest Development Status: Preclinical Product Type: Cell and Gene therapy

              Partner/Sponsor/Collaborator: Not Applicable

              Deal Size: Not Applicable Upfront Cash: Not Applicable

              Deal Type: Not Applicable September 08, 2020

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              Cynata Completes Phase 1 GvHD Clinical Trial Follow-up with Positive Results

              Details:

              The Phase 1 trial, which was the world’s first clinical trial of an allogeneic iPSC-derived MSC product, evaluated the safety and efficacy of CYP-001 for the treatment of patients with steroid-resistant acute graft-versus-host disease (GvHD).

              Lead Product(s): MCA-derived mesenchymal stem cells

              Therapeutic Area: Immunology Product Name: CYP-001

              Highest Development Status: Phase I Product Type: Cell and Gene therapy

              Partner/Sponsor/Collaborator: Not Applicable

              Deal Size: Not Applicable Upfront Cash: Not Applicable

              Deal Type: Not Applicable July 30, 2020

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