
Year
DEALS // DEV.
Country
Therapeutic Area
Study Phase
Deal Type
Product Type
Dosage Form
Lead Product
Target

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Lead Product(s) : Olinciguat,Itraconazole
Therapeutic Area : Psychiatry/Psychology
Study Phase : Phase I
Recipient : Massachusetts Institute of Technology
Deal Size : Undisclosed
Deal Type : Licensing Agreement
Cyclerion Announces Transformational Relaunch as a Neuropsychiatric Company
Details : The agreement marks a pivotal milestone in Cyclerion’s transformation to focus on delivering potential novel, first-in-class therapies, including IW-1701 (olinciguat), for neuropsychiatric conditions.
Product Name : IW-1701
Product Type : Miscellaneous
Upfront Cash : Undisclosed
September 23, 2025
Lead Product(s) : Olinciguat,Itraconazole
Therapeutic Area : Psychiatry/Psychology
Highest Development Status : Phase I
Recipient : Massachusetts Institute of Technology
Deal Size : Undisclosed
Deal Type : Licensing Agreement

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Lead Product(s) : Zagociguat
Therapeutic Area : Genetic Disease
Study Phase : Phase II
Sponsor : Tisento Therapeutics
Deal Size : $8.0 million
Deal Type : Divestment
Tisento Launches with $81 Million from Top-Tier Investor Syndicate and Promising Cyclerion Assets
Details : Under the agreement, Tisento will develop CY6463 (zagociguat), sGC stimulator, to treat Mitochondrial Encephalopathy, Lactic Acidosis, and Stroke-like episodes syndrome (MELAS) and other diseases associated with mitochondrial dysfunction and advance CY30...
Product Name : Undisclosed
Product Type : Miscellaneous
Upfront Cash : $8.0 million
July 31, 2023
Lead Product(s) : Zagociguat
Therapeutic Area : Genetic Disease
Highest Development Status : Phase II
Sponsor : Tisento Therapeutics
Deal Size : $8.0 million
Deal Type : Divestment

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Lead Product(s) : Zagociguat
Therapeutic Area : Genetic Disease
Study Phase : Phase II
Sponsor : Undisclosed
Deal Size : $8.0 million
Deal Type : Divestment
Cyclerion Announces Definitive Agreement for Zagociguat and CY3018
Details : Under the agreement, new company (NewCo) will develop CY6463 (zagociguat), sGC stimulator, to treat Mitochondrial Encephalopathy, Lactic Acidosis, and Stroke-like episodes syndrome (MELAS) and other diseases associated with mitochondrial dysfunction and ...
Product Name : Undisclosed
Product Type : Miscellaneous
Upfront Cash : $8.0 million
May 11, 2023
Lead Product(s) : Zagociguat
Therapeutic Area : Genetic Disease
Highest Development Status : Phase II
Sponsor : Undisclosed
Deal Size : $8.0 million
Deal Type : Divestment

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Lead Product(s) : Zagociguat
Therapeutic Area : Rare Diseases and Disorders
Study Phase : Preclinical
Sponsor : Peter Hecht
Deal Size : $5.0 million
Deal Type : Agreement
Details : The proceeds are used to support the ongoing operations regarding Zagociguat, a CNS-penetrant sGC stimulator that has shown rapid improvements across a range of endpoints reflecting multiple domains of disease activity, including mitochondrial disease-as...
Product Name : Undisclosed
Product Type : Miscellaneous
Upfront Cash : $5.0 million
April 03, 2023
Lead Product(s) : Zagociguat
Therapeutic Area : Rare Diseases and Disorders
Highest Development Status : Preclinical
Sponsor : Peter Hecht
Deal Size : $5.0 million
Deal Type : Agreement

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Lead Product(s) : Zagociguat
Therapeutic Area : Rare Diseases and Disorders
Study Phase : Preclinical
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable
Details : CY6463 (zagociguat), is the first CNS-penetrant sGC stimulator to be developed as a symptomatic and potentially disease-modifying therapy for serious diseases that involve the CNS.
Product Name : Undisclosed
Product Type : Miscellaneous
Upfront Cash : Inapplicable
March 27, 2023
Lead Product(s) : Zagociguat
Therapeutic Area : Rare Diseases and Disorders
Highest Development Status : Preclinical
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable

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Lead Product(s) : Zagociguat
Therapeutic Area : Psychiatry/Psychology
Study Phase : Phase I
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable
Details : Data from 14-day study demonstrated that CY6463 was safe and well tolerated, with no reports of SAEs, severe adverse events AEs, or treatment discontinuation due to AEs. Study data demonstrate a strong effect on cognitive performance after two weeks of 1...
Product Name : Undisclosed
Product Type : Miscellaneous
Upfront Cash : Inapplicable
July 28, 2022
Lead Product(s) : Zagociguat
Therapeutic Area : Psychiatry/Psychology
Highest Development Status : Phase I
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable

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Lead Product(s) : Zagociguat
Therapeutic Area : Rare Diseases and Disorders
Study Phase : Phase II
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable
Details : Data for CY6463, a first-in-class, CNS-penetrant, sGC stimulator, demonstrate safety and positive effects across biomarkers of disease in MELAS patients.
Product Name : Undisclosed
Product Type : Miscellaneous
Upfront Cash : Inapplicable
June 28, 2022
Lead Product(s) : Zagociguat
Therapeutic Area : Rare Diseases and Disorders
Highest Development Status : Phase II
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable

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Lead Product(s) : Zagociguat
Therapeutic Area : Genetic Disease
Study Phase : Phase II
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable
Details : CY6463 is the first CNS-penetrant sGC stimulator, as a positive allosteric modulator to be developed as a symptomatic and potentially disease-modifying therapy for serious CNS diseases.
Product Name : Undisclosed
Product Type : Miscellaneous
Upfront Cash : Inapplicable
June 22, 2022
Lead Product(s) : Zagociguat
Therapeutic Area : Genetic Disease
Highest Development Status : Phase II
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable

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Lead Product(s) : Zagociguat
Therapeutic Area : Ophthalmology
Study Phase : Preclinical
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable
Details : Research from preclinical studies demonstrates treatment with its lead soluble guanylate cyclase (sGC) stimulator, CY6463, was associated with improved cellular energetics and reduced inflammation in preclinical models of mitochondrial disease.
Product Name : Undisclosed
Product Type : Miscellaneous
Upfront Cash : Inapplicable
June 17, 2022
Lead Product(s) : Zagociguat
Therapeutic Area : Ophthalmology
Highest Development Status : Preclinical
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable

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Lead Product(s) : Zagociguat
Therapeutic Area : Genetic Disease
Study Phase : Phase II
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable
Details : CY6463 was well tolerated, with no reports of serious adverse events (SAEs) or treatment discontinuation due to adverse events (AEs); oral, once-daily administration provided expected CNS exposure.
Product Name : Undisclosed
Product Type : Miscellaneous
Upfront Cash : Inapplicable
June 10, 2022
Lead Product(s) : Zagociguat
Therapeutic Area : Genetic Disease
Highest Development Status : Phase II
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable
