[{"orgOrder":0,"company":"Corstasis Therapeutics","sponsor":"Undisclosed","pharmaFlowCategory":"DU","therapeuticArea":"Cardiology\/Vascular Diseases","country":"U.S.A","productType":"Miscellaneous","year":"2025","type":"Inapplicable","leadProduct":"Bumetanide","moa":"Sodium-(potassium)-chloride cotransporter 2","graph1":"Cardiology\/Vascular Diseases","graph2":"Approved FDF","graph3":"Corstasis Therapeutics","amount2":0,"highestDevelopmentShortName":"Approved FDF","therapeuticAreaShortName":"Cardiovascular Diseases","amount2New":0,"dosageForm":"Spray","sponsorNew":"Corstasis Therapeutics \/ Undisclosed","highestDevelopmentStatusID":"15","companyTruncated":"Corstasis Therapeutics \/ Undisclosed"},{"orgOrder":0,"company":"Corstasis Therapeutics","sponsor":"USHV","pharmaFlowCategory":"D","therapeuticArea":"Nephrology","country":"U.S.A","productType":"Miscellaneous","year":"2025","type":"Collaboration","leadProduct":"Bumetanide","moa":"Sodium-(potassium)-chloride cotransporter 2","graph1":"Cardiology\/Vascular Diseases","graph2":"Approved FDF","graph3":"Corstasis Therapeutics","amount2":0,"highestDevelopmentShortName":"Approved FDF","therapeuticAreaShortName":"Cardiovascular Diseases","amount2New":0,"dosageForm":"Spray","sponsorNew":"Corstasis Therapeutics \/ USHV","highestDevelopmentStatusID":"15","companyTruncated":"Corstasis Therapeutics \/ USHV"},{"orgOrder":0,"company":"Corstasis Therapeutics","sponsor":"Aptar Pharma","pharmaFlowCategory":"DU","therapeuticArea":"Nephrology","country":"U.S.A","productType":"Miscellaneous","year":"2025","type":"Inapplicable","leadProduct":"Bumetanide","moa":"Sodium-(potassium)-chloride cotransporter 2","graph1":"Cardiology\/Vascular Diseases","graph2":"Approved FDF","graph3":"Corstasis Therapeutics","amount2":0,"highestDevelopmentShortName":"Approved FDF","therapeuticAreaShortName":"Cardiovascular Diseases","amount2New":0,"dosageForm":"Spray","sponsorNew":"Corstasis Therapeutics \/ Aptar Pharma","highestDevelopmentStatusID":"15","companyTruncated":"Corstasis Therapeutics \/ Aptar Pharma"}]

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                          Therapeutic Area by Lead Product

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                          Top Deals by Deal Size (USD bn)

                          01

                          OTS 2025
                          Not Confirmed
                          OTS 2025
                          Not Confirmed

                          Details : Corstasis and USHV to co-develop value-based care for outpatient fluid overload in CHF, liver, and kidney disease using Enbumyst (bumetanide nasal spray).

                          Product Name : Enbumyst

                          Product Type : Miscellaneous

                          Upfront Cash : Undisclosed

                          September 25, 2025

                          Lead Product(s) : Bumetanide

                          Therapeutic Area : Nephrology

                          Highest Development Status : Approved FDF

                          Sponsor : USHV

                          Deal Size : Undisclosed

                          Deal Type : Collaboration

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                          02

                          OTS 2025
                          Not Confirmed
                          OTS 2025
                          Not Confirmed

                          Details : Enbumyst (bumetanide) appears to block the active reabsorption of chloride and possibly sodium, resulting in excretion of sodium, chloride, and water and, hence, diuresis.

                          Product Name : Enbumyst

                          Product Type : Miscellaneous

                          Upfront Cash : Inapplicable

                          September 18, 2025

                          Lead Product(s) : Bumetanide

                          Therapeutic Area : Nephrology

                          Highest Development Status : Approved FDF

                          Sponsor : Aptar Pharma

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          03

                          OTS 2025
                          Not Confirmed
                          OTS 2025
                          Not Confirmed

                          Details : RSQ-777 (bumetanide is given to help treat edema and swelling that is caused by congestive heart failure, liver disease, kidney disease, or other medical conditions.

                          Product Name : Undisclosed

                          Product Type : Miscellaneous

                          Upfront Cash : Inapplicable

                          January 27, 2025

                          Lead Product(s) : Bumetanide

                          Therapeutic Area : Cardiology/Vascular Diseases

                          Highest Development Status : Phase III

                          Sponsor : Undisclosed

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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