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Find Clinical Drug Pipeline Developments & Deals by ContraFect Corporation
CF-370 will be the first engineered lysin therapeutic targeting Gram-negative pathogens to enter a human clinical trial for hospital-acquired bacterial pneumonia (HABP) and ventilator-associated bacterial pneumonia.
The IND application supports a proposed indication for its intravenous (IV) antibacterial agent, CF-370, for treatment of hospital-acquired bacterial pneumonia (HABP) and ventilator-associated bacterial pneumonia (VABP).
The company intends to use the net proceeds to support ongoing enrollment of patients in the Phase 1b/2 clinical study of intra-articular CF-301 (exebacase), a first-in-class direct lytic agent, for the treatment of chronic prosthetic joint infections of the knee.
CF-301 (exebacase) is a lysin with potent activity against staphylococcus aureus ("Staph aureus"). It has the potential to be the first-in-class of a new treatment for chronic prosthetic joint infections of the knee.
CF-301 (exebacase) is a lysin with potent activity against staphylococcus aureus ("Staph aureus"). Exebacase has the potential to be the first-in-class of a new treatment for patients with Staph aureus bacteremia.
CF-301 (exebacase) is a lysin and member of a new class of targeted protein-based antimicrobials that has demonstrated activity against S. aureus in laboratory (in vitro) and animal studies, alone and in addition to conventional antibiotics.
CF-301 (exebacase) is a lysin and member of a new class of targeted protein-based antimicrobials that has demonstrated activity against S. aureus in laboratory (in vitro) and animal studies, alone and in addition to conventional antibiotics.
The Phase 1b/2 study of exebacase is a randomized, double-blind, placebo-controlled study to assess the efficacy and safety of exebacase in the setting of an arthroscopic DAIR procedure in patients with chronic PJI of the knee due t o S. aureus and/or CoNS.
Company’s lysins, exebacase and CF-296, as additional agents in the treatment armamentarium against bone and joint infections due to their in vitro activity against coagulase-negative staphylococci, and their potential for both local and systemic anti-biofilm activity.
The positive clinical data demonstrated in these patients underpins the potential to prosecute CF-301 (exebacase) in a blinded clinical study of patients with chronic or recurrent prosthetic joint infections caused by MRSA or coagulase-negative Staph.
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