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    [{"orgOrder":0,"company":"Cogent Biosciences","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Gastroenterology","country":"U.S.A","productType":"Other Small Molecule","year":"2022","type":"Inapplicable","leadProduct":"Bezuclastinib","moa":"||c-KIT receptor","graph1":"Gastroenterology","graph2":"Phase III","graph3":"Cogent Biosciences","amount2":0,"highestDevelopmentShortName":"Ph III","therapeuticAreaShortName":"Gastroenterology","amount2New":0,"dosageForm":"Oral Tablet","sponsorNew":"Cogent Biosciences \/ Inapplicable","highestDevelopmentStatusID":"10","companyTruncated":"Cogent Biosciences \/ Inapplicable"},{"orgOrder":0,"company":"Cogent Biosciences","sponsor":"J.P. 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                            01

                            Cogent Biosciences

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                            Lead Product(s) : Bezuclastinib

                            Therapeutic Area : Hematology

                            Study Phase : Phase III

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Cogent Biosciences Shares SUMMIT Phase 2 Data Showing Symptomatic Improvement in AdvSM

                            Details : CGT9486 (bezuclastinib) is a selective tyrosine kinase inhibitor, designed to potently inhibit the KIT D816V mutation. It is being evaluated for the treatment of nonadvanced systemic mastocytosis.

                            Product Name : CGT9486

                            Product Type : Other Small Molecule

                            Upfront Cash : Inapplicable

                            December 09, 2024

                            Lead Product(s) : Bezuclastinib

                            Therapeutic Area : Hematology

                            Highest Development Status : Phase III

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            02

                            Cogent Biosciences

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                            Lead Product(s) : Bezuclastinib

                            Therapeutic Area : Oncology

                            Study Phase : Phase III

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Cogent Announces Positive Data from APEX Phase 2 Trial of Bezuclastinib in AdvSM

                            Details : CGT9486 (bezuclastinib) is a selective tyrosine kinase inhibitor, designed to potently inhibit the KIT D816V mutation. It is being evaluated for the treatment of advanced systemic mastocytosis.

                            Product Name : CGT9486

                            Product Type : Other Small Molecule

                            Upfront Cash : Inapplicable

                            December 08, 2024

                            Lead Product(s) : Bezuclastinib

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase III

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            03

                            Cogent Biosciences

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                            Lead Product(s) : Bezuclastinib

                            Therapeutic Area : Hematology

                            Study Phase : Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Cogent's SUMMIT Trial Data Shows Promise for Bezuclastinib in Patients with NonAdvSM

                            Details : CGT9486 (bezuclastinib) is a selective tyrosine kinase inhibitor, designed to potently inhibit the KIT D816V mutation. It is being evaluated for the treatment of nonadvanced systemic mastocytosis.

                            Product Name : CGT9486

                            Product Type : Other Small Molecule

                            Upfront Cash : Inapplicable

                            June 14, 2024

                            Lead Product(s) : Bezuclastinib

                            Therapeutic Area : Hematology

                            Highest Development Status : Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            04

                            Cogent Biosciences

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                            Lead Product(s) : Bezuclastinib,Sunitinib

                            Therapeutic Area : Oncology

                            Study Phase : Phase III

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Cogent Completes Enrollment in Phase 3 PEAK Trial for Gastrointestinal Stromal Tumors

                            Details : CGT9486 (bezuclastinib), is a KIT mutant inhibitor, being investigated in combination with sunitinib for patients living with gastrointestinal stromal tumors.

                            Product Name : CGT9486

                            Product Type : Other Small Molecule

                            Upfront Cash : Inapplicable

                            March 09, 2024

                            Lead Product(s) : Bezuclastinib,Sunitinib

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase III

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            05

                            Cogent Biosciences

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                            Lead Product(s) : Bezuclastinib

                            Therapeutic Area : Hematology

                            Study Phase : Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Cogent Announces Positive Part 1b Data Evaluating Bezuclastinib in Systemic Mastocytosis

                            Details : CGT9486 (bezuclastinib) is a selective tyrosine kinase inhibitor that is designed to potently inhibit the KIT D816V mutation. It is being evaluated for nonadvanced systemic mastocytosis.

                            Product Name : CGT9486

                            Product Type : Other Small Molecule

                            Upfront Cash : Inapplicable

                            February 22, 2024

                            Lead Product(s) : Bezuclastinib

                            Therapeutic Area : Hematology

                            Highest Development Status : Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            06

                            Cogent Biosciences

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                            Lead Product(s) : Bezuclastinib,Sunitinib

                            Therapeutic Area : Oncology

                            Study Phase : Phase III

                            Sponsor : J.P. Morgan

                            Deal Size : $225.0 million

                            Deal Type : Private Placement

                            DEALS_DEV arrow-down

                            Cogent Biosciences Announces Oversubscribed $225 Million Private Placement

                            Details : The net proceeds will be used for the clinical development of CGT9486 (bezuclastinib), which is a KIT mutant inhibitor for systemic mastocytosis and gastrointestinal stromal tumors.

                            Product Name : CGT9486

                            Product Type : Other Small Molecule

                            Upfront Cash : Undisclosed

                            February 14, 2024

                            Lead Product(s) : Bezuclastinib,Sunitinib

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase III

                            Sponsor : J.P. Morgan

                            Deal Size : $225.0 million

                            Deal Type : Private Placement

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                            07

                            Cogent Biosciences

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                            Lead Product(s) : Bezuclastinib,Sunitinib

                            Therapeutic Area : Gastroenterology

                            Study Phase : Phase III

                            Sponsor : J.P. Morgan

                            Deal Size : $150.0 million

                            Deal Type : Public Offering

                            DEALS_DEV arrow-down

                            Cogent Biosciences Announces Pricing of Upsized Public Offering of Shares of Common Stock

                            Details : Cogent intends to fund the development, regulatory and commercial preparation activities relating to CGT9486 (bezuclastinib), a selective tyrosine kinase inhibitor that is designed to potently inhibit the KIT D816V mutation as well as other mutations in ...

                            Product Name : CGT9486

                            Product Type : Other Small Molecule

                            Upfront Cash : Undisclosed

                            June 06, 2023

                            Lead Product(s) : Bezuclastinib,Sunitinib

                            Therapeutic Area : Gastroenterology

                            Highest Development Status : Phase III

                            Sponsor : J.P. Morgan

                            Deal Size : $150.0 million

                            Deal Type : Public Offering

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                            08

                            Cogent Biosciences

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                            Lead Product(s) : Bezuclastinib

                            Therapeutic Area : Hematology

                            Study Phase : Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Cogent Biosciences Announces Presentation at European Hematology Association (EHA) Annual Congress

                            Details : CGT9486 (bezuclastinib), is a selective tyrosine kinase inhibitor that is designed to potently inhibit the KIT D816V mutation as well as other mutations in KIT exon 17.

                            Product Name : CGT9486

                            Product Type : Other Small Molecule

                            Upfront Cash : Inapplicable

                            December 05, 2022

                            Lead Product(s) : Bezuclastinib

                            Therapeutic Area : Hematology

                            Highest Development Status : Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            09

                            Cogent Biosciences

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                            Lead Product(s) : Bezuclastinib

                            Therapeutic Area : Hematology

                            Study Phase : Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Cogent Biosciences Presents Nonclinical Data at AACR Annual Meeting and Provides Updates on Portfolio Expansio...

                            Details : New CGT9486 (bezuclastinib) nonclinical data demonstrated superior selectivity against closely related kinases, as well as minimal brain penetration, compared with other KIT inhibitors.

                            Product Name : CGT9486

                            Product Type : Other Small Molecule

                            Upfront Cash : Inapplicable

                            November 04, 2022

                            Lead Product(s) : Bezuclastinib

                            Therapeutic Area : Hematology

                            Highest Development Status : Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            10

                            Cogent Biosciences

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                            Lead Product(s) : Bezuclastinib

                            Therapeutic Area : Hematology

                            Study Phase : Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Cogent Biosciences Announces Positive Initial Clinical Data from Ongoing Phase 2 APEX Trial Evaluating Bezucla...

                            Details : All patients treated with CGT9486 (bezuclastinib) achieved ≥50% reduction in serum tryptase, with a median reduction of 89%, regardless of prior KIT D816V inhibitor treatment.

                            Product Name : CGT9486

                            Product Type : Other Small Molecule

                            Upfront Cash : Inapplicable

                            October 06, 2022

                            Lead Product(s) : Bezuclastinib

                            Therapeutic Area : Hematology

                            Highest Development Status : Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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